Molecular structure of 2-Chloroadenosine, CAS Number: 146-77-0
2-Chloroadenosine (CAS 146-77-0)
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Alternate Names:
2-CADO
Application:
2-Chloroadenosine is an Adenosine A receptor agonist
CAS Number:
146-77-0
Purity:
≥98%
Molecular Weight:
301.69
Molecular Formula:
C10H12ClN5O4
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
A metabolically stable analog of adenosine that behaves as an adenosine receptor agonist (Ki values are 300, 80 and 1900 nM for A1, A2A and A3 receptors respectively).
2-Chloroadenosine (CAS 146-77-0) References
- 2-Chloroadenosine, a preferential agonist of adenosine A1 receptors, enhances the anticonvulsant activity of carbamazepine and clonazepam in mice. | Borowicz, KK., et al. 2002. Eur Neuropsychopharmacol. 12: 173-9. PMID: 11872335
- STRONG INHIBITION BY 2-CHLOROADENOSINE OF THE AGGREGATION OF BLOOD PLATELETS BY ADENOSINE DIPHOSPHATE. | BORN, GV. 1964. Nature. 202: 95-6. PMID: 14166734
- Mechanism of 2-chloroadenosine toxicity to PC3 cell line. | Minelli, A., et al. 2006. Prostate. 66: 1425-36. PMID: 16741921
- 2-Chloroadenosine attenuates NMDA, kainate, and quisqualate toxicity. | Finn, SF., et al. 1991. Neurosci Lett. 126: 191-4. PMID: 1922933
- 2-Chloroadenosine decreases long-term potentiation in the hippocampal CA1 area of the rat. | de Mendonça, A. and Ribeiro, JA. 1990. Neurosci Lett. 118: 107-11. PMID: 2259460
- 2-chloroadenosine attenuates kainic acid-induced toxicity within the rat straitum: relationship to release of glutamate and Ca2+ influx. | Arvin, B., et al. 1989. Br J Pharmacol. 98: 225-35. PMID: 2804547
- An activator of protein kinase C (phorbol-12-myristate-13-acetate) augments 2-chloroadenosine-elicited accumulation of cyclic AMP in guinea pig cerebral cortical particulate preparations. | Hollingsworth, EB., et al. 1985. FEBS Lett. 184: 339-42. PMID: 2987034
- An adenosine analogue, 2-chloroadenosine, protects against long term development of ischaemic cell loss in the rat hippocampus. | Evans, MC., et al. 1987. Neurosci Lett. 83: 287-92. PMID: 3441311
- The adenosine agonist 2-chloroadenosine inhibits the induction of long-term potentiation of the perforant path. | Dolphin, AC. 1983. Neurosci Lett. 39: 83-9. PMID: 6314194
- 2-chloroadenosine stimulates granule exocytosis from mouse natural killer cells: evidence for signal transduction through a novel extracellular receptor. | Williams, BA., et al. 1997. Exp Cell Res. 233: 187-97. PMID: 9184087
- Intra-amygdala infusion of 2-chloroadenosine suppresses amygdala-kindled seizures. | Pourgholami, MH., et al. 1997. Brain Res. 775: 37-42. PMID: 9439826
Activator of:
Adenosine A1-R, Adenosine A2A-R, and Adenosine A3-R.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
2-Chloroadenosine, 50 mg | sc-203768 | 50 mg | $103.00 |