Tollip Activators
Tollip activators form a diverse array of chemicals strategically designed to modulate the activity of Tollip, a pivotal regulator in the realms of innate immunity and inflammation. These activators primarily focus on the NF-κB signaling pathway, effectively influencing Tollip expression and activity to shape cellular responses. Among these, Resveratrol, a polyphenolic compound, stands out as an activator that achieves Tollip activation by inhibiting NF-κB, thus creating an environment conducive to Tollip function. The intricate modulation of this signaling pathway by Resveratrol underscores the potential of Tollip as a key player in immune regulation. Similarly, a cohort of compounds including curcumin, celastrol, baicalein, and andrographolide act as Tollip activators through their ability to suppress NF-κB-mediated inflammation. By targeting this central signaling pathway, these chemicals facilitate the activation of Tollip, offering a nuanced approach to influencing immune responses. Parthenolide, guggulsterone, withaferin A, thymoquinone, celery seed extract, honokiol, and xanthohumol contribute to the repertoire of Tollip activators. Their mode of action involves the modulation of the NF-κB pathway, leading to heightened Tollip expression and subsequent activity. This indirect activation pathway, characterized by the inhibition of NF-κB-mediated inflammatory responses, creates a cellular environment that supports Tollip function.
The NF-κB pathway, known for its central role in immune and inflammatory responses, becomes a focal point for Tollip activators. These compounds strategically intervene to enhance Tollip expression and activity. The intricate interplay between Tollip and its activators provides valuable insights into the complex regulatory networks governing immune responses and inflammation. Exploring the potential of Tollip activators may unveil novel strategies for modulating innate immunity, offering promising avenues for managing inflammatory disorders. As research progresses, a deeper understanding of Tollip activation mechanisms may contribute to the development of innovative approaches to immune modulation and strategies aimed at fine-tuning inflammatory responses.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Resveratrol | 501-36-0 | sc-200808 sc-200808A sc-200808B | 100 mg 500 mg 5 g | $80.00 $220.00 $460.00 | 64 | |
Activates Tollip by modulating the NF-κB signaling pathway. Resveratrol inhibits NF-κB activation, leading to increased Tollip expression and activity. This compound may indirectly activate Tollip by dampening the inflammatory response mediated by NF-κB, promoting cellular homeostasis. | ||||||
Curcumin | 458-37-7 | sc-200509 sc-200509A sc-200509B sc-200509C sc-200509D sc-200509F sc-200509E | 1 g 5 g 25 g 100 g 250 g 1 kg 2.5 kg | $37.00 $69.00 $109.00 $218.00 $239.00 $879.00 $1968.00 | 47 | |
Indirectly activates Tollip by influencing the NF-κB signaling pathway. Curcumin inhibits NF-κB activation, leading to enhanced Tollip expression and activity. Through its anti-inflammatory properties, curcumin can modulate Tollip activation by suppressing NF-κB-mediated inflammatory responses, promoting a cellular environment conducive to Tollip function. | ||||||
Celastrol, Celastrus scandens | 34157-83-0 | sc-202534 | 10 mg | $158.00 | 6 | |
Activates Tollip through the modulation of the NF-κB pathway. Celastrol inhibits NF-κB activation, leading to increased Tollip expression and activity. This compound may indirectly activate Tollip by mitigating NF-κB-mediated inflammatory signaling, fostering an environment favorable for Tollip function. | ||||||
Baicalein | 491-67-8 | sc-200494 sc-200494A sc-200494B sc-200494C | 10 mg 100 mg 500 mg 1 g | $32.00 $42.00 $162.00 $292.00 | 12 | |
Indirectly activates Tollip by influencing the NF-κB signaling pathway. Baicalein inhibits NF-κB activation, leading to enhanced Tollip expression and activity. Through its anti-inflammatory properties, baicalein modulates Tollip activation by suppressing NF-κB-mediated inflammatory responses, creating a cellular milieu supportive of Tollip function. | ||||||
Andrographolide | 5508-58-7 | sc-205594 sc-205594A | 50 mg 100 mg | $15.00 $40.00 | 7 | |
Activates Tollip through modulation of the NF-κB signaling pathway. Andrographolide inhibits NF-κB activation, resulting in increased Tollip expression and activity. This compound may indirectly activate Tollip by suppressing NF-κB-mediated inflammation, fostering a cellular environment conducive to Tollip function. | ||||||
Parthenolide | 20554-84-1 | sc-3523 sc-3523A | 50 mg 250 mg | $81.00 $306.00 | 32 | |
Indirectly activates Tollip by modulating the NF-κB signaling pathway. Parthenolide inhibits NF-κB activation, leading to enhanced Tollip expression and activity. Through its anti-inflammatory properties, parthenolide can influence Tollip activation by suppressing NF-κB-mediated inflammatory responses, promoting a cellular context favorable for Tollip function. | ||||||
Z-Guggulsterone | 39025-23-5 | sc-204414B sc-204414 sc-204414A | 5 mg 10 mg 25 mg | $193.00 $369.00 $733.00 | 28 | |
Activates Tollip by influencing the NF-κB signaling pathway. Guggulsterone inhibits NF-κB activation, resulting in increased Tollip expression and activity. This compound may indirectly activate Tollip by mitigating NF-κB-mediated inflammatory signaling, creating a cellular environment supportive of Tollip function. | ||||||
Withaferin A | 5119-48-2 | sc-200381 sc-200381A sc-200381B sc-200381C | 1 mg 10 mg 100 mg 1 g | $130.00 $583.00 $4172.00 $20506.00 | 20 | |
Indirectly activates Tollip through modulation of the NF-κB signaling pathway. Withaferin A inhibits NF-κB activation, leading to enhanced Tollip expression and activity. Through its anti-inflammatory properties, withaferin A can influence Tollip activation by suppressing NF-κB-mediated inflammatory responses, fostering a cellular milieu conducive to Tollip function. | ||||||
Thymoquinone | 490-91-5 | sc-215986 sc-215986A | 1 g 5 g | $47.00 $133.00 | 21 | |
Activates Tollip by influencing the NF-κB signaling pathway. Thymoquinone inhibits NF-κB activation, resulting in increased Tollip expression and activity. This compound may indirectly activate Tollip by mitigating NF-κB-mediated inflammatory signaling, creating a cellular environment supportive of Tollip function. | ||||||
Honokiol | 35354-74-6 | sc-202653 sc-202653A | 10 mg 25 mg | $118.00 $178.00 | 4 | |
Indirectly activates Tollip by influencing the NF-κB signaling pathway. Honokiol inhibits NF-κB activation, leading to enhanced Tollip expression and activity. Through its anti-inflammatory properties, honokiol can modulate Tollip activation by suppressing NF-κB-mediated inflammatory responses, creating a cellular context favorable for Tollip function. | ||||||