Tollip Inhibitors
Tollip, an endosomal trafficking protein with critical roles in immune regulation, is an emerging target for modulation. While direct Tollip inhibitors are limited, a range of chemicals indirectly impact Tollip function by targeting various cellular pathways associated with Tollip-mediated processes. P5091, a deubiquitinase inhibitor, indirectly modulates Tollip by preventing the removal of ubiquitin groups from target proteins. This disruption of ubiquitin dynamics impacts Tollip's role in endosomal trafficking and immune responses. MLN4924, an NEDD8-activating enzyme inhibitor, alters Tollip function by inhibiting the NEDDylation pathway, affecting Tollip-associated cellular processes. Histone acetyltransferase (HAT) inhibitor C646 influences Tollip by altering histone acetylation, potentially impacting Tollip expression levels. SBI-0206965, a TBK1/IKKε inhibitor, indirectly impacts Tollip by disrupting the TBK1/IKKε signaling pathway, modulating Tollip-associated immune responses.
BAY 11-7082, a NF-κB activation inhibitor, indirectly affects Tollip by modulating the NF-κB signaling pathway. NSC 697923, a Tankyrase inhibitor, stabilizes Axin in the Wnt/β-catenin pathway, influencing Tollip-associated cellular processes. GSK'963, a RIP1 kinase inhibitor, modulates Tollip by regulating RIP1-dependent signaling pathways. BI605906, a Cdc7 kinase inhibitor, indirectly influences Tollip by targeting the Cdc7-mediated signaling pathway. BX795 and AZD8055, inhibitors of TBK1/IKKε and mTOR, respectively, impact Tollip by disrupting their respective signaling pathways. BX912, an AMPK inhibitor, alters Tollip-associated functions by influencing AMPK-mediated pathways. K858, a CDK7 inhibitor, modulates Tollip by affecting CDK7-associated cellular processes. This diverse array of inhibitors provides valuable tools to dissect Tollip's intricate involvement in cellular processes.
SEE ALSO...
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
P005091 | 882257-11-6 | sc-478535 | 10 mg | $155.00 | ||
P005091 is a deubiquitinase (DUB) inhibitor that indirectly modulates Tollip by preventing the removal of ubiquitin groups from target proteins. Tollip, involved in endosomal trafficking, relies on ubiquitin modification for its functions. Inhibiting DUBs like P5091 disrupts the ubiquitin system, impacting Tollip-mediated cellular processes. | ||||||
MLN 4924 | 905579-51-3 | sc-484814 | 1 mg | $280.00 | 1 | |
MLN4924 is an NEDD8-activating enzyme (NAE) inhibitor that indirectly influences Tollip through the inhibition of the NEDDylation pathway. Tollip is subject to NEDD8 modification, and disrupting NEDDylation with MLN4924 can alter Tollip function by preventing its modification, affecting Tollip-associated endosomal trafficking and immune responses. | ||||||
C646 | 328968-36-1 | sc-364452 sc-364452A | 10 mg 50 mg | $260.00 $925.00 | 5 | |
C646 is a histone acetyltransferase (HAT) inhibitor that indirectly modulates Tollip by influencing histone acetylation. Tollip expression can be regulated by histone modifications, and inhibiting HATs like C646 alters the acetylation landscape, potentially affecting Tollip expression levels and, consequently, Tollip-mediated cellular processes. | ||||||
SBI-0206965 | 1884220-36-3 | sc-507431 | 10 mg | $122.00 | ||
SBI-0206965 is a TBK1/IKKε inhibitor that indirectly impacts Tollip by interfering with the TBK1/IKKε signaling pathway. Tollip has been implicated in the regulation of TBK1/IKKε-mediated immune responses. Inhibiting TBK1/IKKε with SBI-0206965 can disrupt this pathway, modulating Tollip-associated processes related to immune regulation and endosomal trafficking. | ||||||
BAY 11-7082 | 19542-67-7 | sc-200615B sc-200615 sc-200615A | 5 mg 10 mg 50 mg | $61.00 $83.00 $349.00 | 155 | |
BAY 11-7082 is an inhibitor of NF-κB activation that indirectly affects Tollip through the modulation of the NF-κB signaling pathway. Tollip has been linked to NF-κB-mediated immune responses. Inhibiting NF-κB activation with BAY 11-7082 can influence Tollip-associated processes, potentially altering Tollip's role in the regulation of immune responses and endosomal trafficking. | ||||||
NSC697923 | 343351-67-7 | sc-391107 sc-391107A | 1 mg 5 mg | $15.00 $51.00 | 3 | |
NSC 697923 is a Tankyrase inhibitor that indirectly modulates Tollip by impacting the Wnt/β-catenin signaling pathway. Tollip has been associated with the Wnt/β-catenin pathway, and inhibiting Tankyrase with NSC 697923 can stabilize Axin, influencing Tollip-associated cellular processes related to endosomal trafficking and immune responses. | ||||||
BX 795 | 702675-74-9 | sc-281689 sc-281689A sc-281689C sc-281689B sc-281689D sc-281689E | 2 mg 5 mg 10 mg 25 mg 50 mg 100 mg | $219.00 $273.00 $331.00 $495.00 $882.00 $1489.00 | 5 | |
BX795 is a TBK1/IKKε inhibitor that indirectly impacts Tollip by interfering with the TBK1/IKKε signaling pathway. Tollip has been implicated in the regulation of TBK1/IKKε-mediated immune responses. Inhibiting TBK1/IKKε with BX795 can disrupt this pathway, modulating Tollip-associated processes related to immune regulation and endosomal trafficking. | ||||||
AZD8055 | 1009298-09-2 | sc-364424 sc-364424A | 10 mg 50 mg | $160.00 $345.00 | 12 | |
AZD8055 is an mTOR inhibitor that indirectly modulates Tollip through the inhibition of the mTOR signaling pathway. Tollip has been associated with cellular processes regulated by mTOR. Inhibiting mTOR with AZD8055 can impact Tollip-associated functions, potentially altering Tollip's role in endosomal trafficking and immune responses. | ||||||