SBI-0206965 (CAS 1884220-36-3)
Alternate Names:
2-((5-Bromo-2-((3,4,5-trimethoxyphenyl)amino)pyrimidin-4-yl)oxy)-N-methylbenzamide; SBI 0206965; SBI0206965
CAS Number:
1884220-36-3
Molecular Weight:
489.30
Molecular Formula:
C21H21BrN4O5
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
QUICK LINKS
Ordering Information
Description
Technical Information
Safety Information
SDS & Certificate of Analysis
SBI-0206965 (CAS 1884220-36-3) References
- Lipophagy deficiency exacerbates ectopic lipid accumulation and tubular cells injury in diabetic nephropathy. | Han, Y., et al. 2021. Cell Death Dis. 12: 1031. PMID: 34718329
- Brain Permeable AMP-Activated Protein Kinase Activator R481 Raises Glycaemia by Autonomic Nervous System Activation and Amplifies the Counterregulatory Response to Hypoglycaemia in Rats. | Cruz, AM., et al. 2021. Front Endocrinol (Lausanne). 12: 697445. PMID: 34975743
- Trehalose induces B cell autophagy to alleviate myocardial injury via the AMPK/ULK1 signalling pathway in acute viral myocarditis induced by Coxsackie virus B3. | Wei, B., et al. 2022. Int J Biochem Cell Biol. 146: 106208. PMID: 35381374
- Brain pharmacokinetics and metabolism of the AMP-activated protein kinase selective inhibitor SBI-0206965, an investigational agent for the treatment of glioblastoma. | Desai, JM., et al. 2022. Invest New Drugs. 40: 944-952. PMID: 35802287
- Porcine epidemic diarrhoea virus (PEDV) infection activates AMPK and JNK through TAK1 to induce autophagy and enhance virus replication. | Wang, J., et al. 2022. Virulence. 13: 1697-1712. PMID: 36168145
- Effect of Size and Concentration of Copper Nanoparticles on the Antimicrobial Activity in Escherichia coli through Multiple Mechanisms. | Lai, MJ., et al. 2022. Nanomaterials (Basel). 12: PMID: 36364491
- Repurposing the tyrosine kinase inhibitor nilotinib for use against intracellular multidrug-resistant Salmonella Typhimurium. | Chou, SH., et al. 2023. J Microbiol Immunol Infect. 56: 490-498. PMID: 36702646
- Mitochondrial Oxidative Stress and Mitophagy Activation Contribute to TNF-Dependent Impairment of Myogenesis. | Chernyavskij, DA., et al. 2023. Antioxidants (Basel). 12: PMID: 36978858
- Evaluation of the Effectiveness of Various Autophagy Inhibitors in A549 Cancer Stem Cells. | Aleksandrova, KV. and Suvorova, II. 2023. Acta Naturae. 15: 19-25. PMID: 37153502
- Atg5 knockout induces alternative autophagy via the downregulation of Akt expression. | Kim, HG., et al. 2023. Toxicol Res. 39: 637-647. PMID: 37779593
- ULK1 confers neuroprotection by regulating microglial/macrophages activation after ischemic stroke. | Xiong, Y., et al. 2024. Int Immunopharmacol. 127: 111379. PMID: 38141409
- BAY-3827 and SBI-0206965: Potent AMPK Inhibitors That Paradoxically Increase Thr172 Phosphorylation. | Hawley, SA., et al. 2023. Int J Mol Sci. 25: PMID: 38203624
- AP39 through AMPK-ULK1-FUNDC1 pathway regulates mitophagy, inhibits pyroptosis, and improves doxorubicin-induced myocardial fibrosis. | Zhao, J., et al. 2024. iScience. 27: 109321. PMID: 38558936
Inhibitor of:
ACSBG2, AMBRA1, AMPKβ1, AMPKβ2, AMPKγ1, AQR, Atg13, Atg16L2, Atg2A, C10orf27, C11orf74, C12orf44, CILP-2, DUSP (Dual specificity protein phosphatase), EVA1B, GCN2, KIAA0226, KIAA0652, MBOAT4, MO25, NPRL3, NRBF2, Rag B, Ser/Thr Protein Kinase, SGK, TECPR2, Tollip, TRIM16, ULK1, ULK2, WDR47, ZFAND2A, and ZKSCAN3.Activator of:
Atg12, DRAM, EF-1δ, eIF4E3, GABARAPL2, WDFY1, and WDFY2.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
SBI-0206965, 10 mg | sc-507431 | 10 mg | $124.00 |