BX 795 CAS: 702675-74-9
MF: C23H26IN7O2S
MW: 591.47
An inhibitor of PDK1, TBK1, and IKK&epsilon.

BX 795 (CAS 702675-74-9)

BX 795 | CAS 702675-74-9 is rated 5.0 out of 5 by 1.
  • y_2020, m_3, d_29, h_14
  • bvseo_bulk, prod_bvrr, vn_bulk_3.0.5
  • cp_1, bvpage1
  • co_hasreviews, tv_0, tr_1
  • loc_en_US, sid_281689, prod, sort_[SortEntry(order=SUBMISSION_TIME, direction=DESCENDING)]
  • clientName_scbt
  • bvseo_sdk, java_sdk, bvseo-3.2.0
  • CLOUD, getAggregateRating, 130ms
  • REVIEWS, PRODUCT
5
1
4
0
3
0
2
0
1
0
Synonym: N-[3-[[5-IODO-4-[[3-[(2-THIENYLCARBONYL)AMINO]PROPYL]AMINO]-2-PYRIMIDINYL]AMINO]PHENYL]-1-PYRROLIDINECARBOXAMIDE
Application: An inhibitor of PDK1, TBK1, and IKK&epsilon
CAS Number: 702675-74-9
Purity: >95%
Molecular Weight: 591.47
Molecular Formula: C23H26IN7O2S
* Refer to Certificate of Analysis for lot specific data (including water content).
Submit a review for this product and receive 15 CruzCredits

BX 795 is shown to be a specific and potent inhibitor of IκB kinase ε (IKKε), phosphoinositide 3-kinase 1 (PDK1), and TANK-binding kinase 1 (TBK1). These protein kinases regulate production of type 1 interferons during certain infections. BX 795 has been suggested in studies to block nuclear translocation, phosphorylation, and transcriptional activity of interferon regulatory factor 3. This in turn blocks the production of interferon-β in macrophages. Further experiments have shown that BX 795 is capable of blocking the autophosphorylation of overexpressed TBK1 and IκKε


References

1. Feldman, R.I., et al. 2005. J. Biol. Chem. 280: 19867-19874. PMID: 15772071
2. Clark, K., et al. 2009. J. Biol. Chem. 284: 14136-14146. PMID: 19307177

Physical State :
Solid
Storage :
Store at 4° C
Density :
~1.6 g/cm3 (Predicted)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
PubChem CID :
10077147
SMILES :
C1CCN(C1)C(=O)NC2=CC=CC(=C2)NC3=NC=C(C(=N3)NCCCNC(=O)C4=CC=CS4)I

Download SDS (MSDS)

Certificate of Analysis

Adobe Acrobat Reader is required to reliably view,
print and comment on PDF documents

BX 795  Product Citations

See how others have used BX 795. Click on the entry to view the PubMed entry .

Citations 1 to 4 of 4 total

PMID: # 28112176  Su, AR. et al. 2017. Acta Pharmacol. Sin. 38: 402-414.

PMID: # 28871090  Sparrer, KMJ. et al. 2017. Nat Microbiol. 2: 1543-1557.

PMID: # 25218983  Nakajima, A. et al. 2014. Eur. J. Pharmacol. 745: 166-75.

PMID: # 23876795  Arsenault, RJ. et al. 2013. Cell. Signal. 25: 2246-54.

Citations 1 to 4 of 4 total
  • bvseo_sdk, java_sdk, bvseo-3.2.0
  • CLOUD, getContent, 109ms
  • QUESTIONS, PRODUCT
  • bvseo-msg: The resource to the URL or file is currently unavailable.;
Rated 5 out of 5 by from Clark et al Clark et al. (PubMed ID 19307177) used BX 795 to inhibit TBK1 and IKKepsilon by preventing the phosphorylation of interferon regulatory factor 3. -SCBT Publication Review
Date published: 2015-02-12
  • y_2020, m_3, d_29, h_14
  • bvseo_bulk, prod_bvrr, vn_bulk_3.0.5
  • cp_1, bvpage1
  • co_hasreviews, tv_0, tr_1
  • loc_en_US, sid_281689, prod, sort_[SortEntry(order=SUBMISSION_TIME, direction=DESCENDING)]
  • clientName_scbt
  • bvseo_sdk, java_sdk, bvseo-3.2.0
  • CLOUD, getReviews, 21ms
  • REVIEWS, PRODUCT

Santa Cruz Biotechnology, Inc. is a world leader in the development of products for the biomedical research market. Call us Toll Free at 1-800-457-3801.
Copyright © 2007-2020 Santa Cruz Biotechnology, Inc. All Rights Reserved. "Santa Cruz Biotechnology", and the Santa Cruz Biotechnology, Inc. logo, "Santa Cruz Animal Health", "San Juan Ranch", "Supplement of Champions", the San Juan Ranch logo, "Ultracruz", "Chemcruz", "Immunocruz", "Exactacruz", and "EZ Touch" are registered trademarks of Santa Cruz Biotechnology, Inc.
All trademarks are the property of their respective owners.