Molecular structure of BX 795, CAS Number: 702675-74-9
BX 795 (CAS 702675-74-9)
See product citations (5)
Alternate Names:
N-[3-[[5-IODO-4-[[3-[(2-THIENYLCARBONYL)AMINO]PROPYL]AMINO]-2-PYRIMIDINYL]AMINO]PHENYL]-1-PYRROLIDINECARBOXAMIDE
Application:
BX 795 is an inhibitor of PDK1, TBK1, and IKK&epsilon
CAS Number:
702675-74-9
Purity:
>95%
Molecular Weight:
591.47
Molecular Formula:
C23H26IN7O2S
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
BX 795 is shown to be a specific and potent inhibitor of IKKε (IkappaB kinase epsilon), phosphoinositide 3-kinase 1 (PDK1), and TANK-binding kinase 1 (TBK1). These protein kinases regulate production of type 1 interferons during certain infections. BX 795 has been suggested in studies to block nuclear translocation, phosphorylation, and transcriptional activity of interferon regulatory factor 3. This in turn blocks the production of interferon-beta in macrophages. Further experiments have shown that BX 795 is capable of blocking the autophosphorylation of overexpressed TBK1 and IkappaKepsilon
BX 795 (CAS 702675-74-9) References
- Novel small molecule inhibitors of 3-phosphoinositide-dependent kinase-1. | Feldman, RI., et al. 2005. J Biol Chem. 280: 19867-74. PMID: 15772071
- Use of the pharmacological inhibitor BX795 to study the regulation and physiological roles of TBK1 and IkappaB kinase epsilon: a distinct upstream kinase mediates Ser-172 phosphorylation and activation. | Clark, K., et al. 2009. J Biol Chem. 284: 14136-46. PMID: 19307177
- Phosphorylation of microtubule-associated protein tau by AMPK-related kinases. | Yoshida, H. and Goedert, M. 2012. J Neurochem. 120: 165-76. PMID: 21985311
- BX-795 inhibits HSV-1 and HSV-2 replication by blocking the JNK/p38 pathways without interfering with PDK1 activity in host cells. | Su, AR., et al. 2017. Acta Pharmacol Sin. 38: 402-414. PMID: 28112176
- A pharmacogenomic analysis using L1000CDS2 identifies BX-795 as a potential anticancer drug for primary pancreatic ductal adenocarcinoma cells. | Choi, EA., et al. 2019. Cancer Lett. 465: 82-93. PMID: 31404615
- Phospho-inositide-dependent kinase 1 regulates signal dependent translation in megakaryocytes and platelets. | Manne, BK., et al. 2020. J Thromb Haemost. 18: 1183-1196. PMID: 31997536
- Elevated PDK1 Expression Drives PI3K/AKT/MTOR Signaling Promotes Radiation-Resistant and Dedifferentiated Phenotype of Hepatocellular Carcinoma. | Bamodu, OA., et al. 2020. Cells. 9: PMID: 32197467
- Phosphoinositide-dependent Kinase-1 (PDPK1) regulates serum/glucocorticoid-regulated Kinase 3 (SGK3) for prostate cancer cell survival. | Nalairndran, G., et al. 2020. J Cell Mol Med. 24: 12188-12198. PMID: 32926495
- PDK1 Inhibitor BX795 Improves Cisplatin and Radio-Efficacy in Oral Squamous Cell Carcinoma by Downregulating the PDK1/CD47/Akt-Mediated Glycolysis Signaling Pathway. | Pai, S., et al. 2021. Int J Mol Sci. 22: PMID: 34768921
- BX-795 inhibits neuroblastoma growth and enhances sensitivity towards chemotherapy. | Chilamakuri, R., et al. 2022. Transl Oncol. 15: 101272. PMID: 34823094
- Putative targeting by BX795 causes decrease in protein kinase C protein levels and inhibition of HSV1 infection. | Suryawanshi, RK., et al. 2022. Antiviral Res. 208: 105454. PMID: 36334637
- Comprehensive analysis of cuproptosis-related lncRNAs in the prognosis and therapy response of patients with bladder cancer. | Li, D., et al. 2022. Ann Transl Med. 10: 1232. PMID: 36544685
Inhibitor of:
2010002M12Rik, ARRDC3, CARD 12, Cbl-b, CPSF3L, Cruz Tag 09TM, D5Ertd577e, DDX1, DDX17, DDX41, DDX60, DHX33, EG243866, FAM49B, Fbxw21, FLJ10489, G-CSFR, HIPK2, HSV-1 gC, HSV-1 gD, HSV-1 ICP27, HSV-2 gB, IFI-16, IGF2BP2, IKK, IL-1RAcP, IRAK-M, IRF-3, IRF-5, IRF-7, KSHV ORF 45, KSHV ORF 62, MAVS, MSE55, NLR family CARD domain-containing (NLRC), OTTMUSG00000011262, OTTMUSG00000011265, PAPD4, PDK1, Pellino 2, Plasmacytoid DC Marker, POLDIP3, RIG-I, SGK2, TBK1, TBKBP1, THOC1, TICAM-1, TLR6, Tollip, TREM-3, TRIM27, TRIM30C, ZCCHC3, and ZMAT4.Activator of:
CCDC22, IFN-α1, IFN-α6, Integrin β6, IRAK-1, Mndal, NEDD4-L, OTTMUSG00000011269, PDK1, RSAD2, and TPTE.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
BX 795, 2 mg | sc-281689 | 2 mg | $219.00 | |||
BX 795, 5 mg | sc-281689A | 5 mg | $273.00 | |||
BX 795, 10 mg | sc-281689C | 10 mg | $331.00 | |||
BX 795, 25 mg | sc-281689B | 25 mg | $495.00 | |||
BX 795, 50 mg | sc-281689D | 50 mg | $882.00 | |||
BX 795, 100 mg | sc-281689E | 100 mg | $1489.00 |