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BX 795 is shown to be a specific and potent inhibitor of IκB kinase ε (IKKε), phosphoinositide 3-kinase 1 (PDK1), and TANK-binding kinase 1 (TBK1). These protein kinases regulate production of type 1 interferons during certain infections. BX 795 has been suggested in studies to block nuclear translocation, phosphorylation, and transcriptional activity of interferon regulatory factor 3. This in turn blocks the production of interferon-β in macrophages. Further experiments have shown that BX 795 is capable of blocking the autophosphorylation of overexpressed TBK1 and IκKε
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2. Clark, K., et al. 2009. J. Biol. Chem. 284: 14136-14146. PMID: 19307177
See how others have used BX 795. Click on the entry to view the PubMed entry .
PMID: # 28112176 Su, AR. et al. 2017. Acta Pharmacol. Sin. 38: 402-414.
PMID: # 28871090 Sparrer, KMJ. et al. 2017. Nat Microbiol. 2: 1543-1557.
PMID: # 25218983 Nakajima, A. et al. 2014. Eur. J. Pharmacol. 745: 166-75.
PMID: # 23876795 Arsenault, RJ. et al. 2013. Cell. Signal. 25: 2246-54.
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