Molecular structure of Z-Guggulsterone, CAS Number: 39025-23-5
Z-Guggulsterone (CAS 39025-23-5)
See product citations (28)
Alternate Names:
Z-Guggulsterone is also known as pregna-4,17Z(20)-diene-3,16-dione.
Application:
Z-Guggulsterone is a selective antagonist of farnesoid X receptor and inhibitor of FXR transactivation.
CAS Number:
39025-23-5
Molecular Weight:
312.45
Molecular Formula:
C21H28O2
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
Z-Guggulsterone is a synthetic form of the guggul tree plant steroid. Z-Guggulsterone exhibits an ability to lower LDL cholesterol and triglyceride levels. Z-Guggulsterone also acts as a selective antagonist of farnesoid X receptor (FXR). In the presence of 100 μM chenodeoxycholic acid (IC50 = 10 μM), Z-Guggulsterone inhibits FXR transactivation. Z-Guggulsterone does not activate or inhibit transactivation of liver X receptor α (LXRα), peroxisome proliferator activated receptor γ (PPARγ), or retinoid X receptor α (RXRα).
Z-Guggulsterone (CAS 39025-23-5) References
- Simultaneous Estimation of Withaferin A and Z-Guggulsterone in Marketed Formulation by RP-HPLC. | Agrawal, P., et al. 2015. J Chromatogr Sci. 53: 940-4. PMID: 25572656
- Z-guggulsterone negatively controls microglia-mediated neuroinflammation via blocking IκB-α-NF-κB signals. | Huang, C., et al. 2016. Neurosci Lett. 619: 34-42. PMID: 26879835
- Z-Guggulsterone Improves the Scopolamine-Induced Memory Impairments Through Enhancement of the BDNF Signal in C57BL/6J Mice. | Chen, Z., et al. 2016. Neurochem Res. 41: 3322-3332. PMID: 27677871
- Z-Guggulsterone Produces Antidepressant-Like Effects in Mice through Activation of the BDNF Signaling Pathway. | Liu, FG., et al. 2017. Int J Neuropsychopharmacol. 20: 485-497. PMID: 28339691
- Z-Guggulsterone attenuates astrocytes-mediated neuroinflammation after ischemia by inhibiting toll-like receptor 4 pathway. | Liu, T., et al. 2018. J Neurochem. 147: 803-815. PMID: 30168601
- Bile acids promote gastric intestinal metaplasia by upregulating CDX2 and MUC2 expression via the FXR/NF-κB signalling pathway. | Yu, JH., et al. 2019. Int J Oncol. 54: 879-892. PMID: 30747230
- Z-Guggulsterone attenuates glucocorticoid-induced osteoporosis through activation of Nrf2/HO-1 signaling. | Xu, Y., et al. 2019. Life Sci. 224: 58-66. PMID: 30905781
- Z-guggulsterone regulates MDR1 expression mainly through the pregnane X receptor-dependent manner in human brain microvessel endothelial cells. | Xu, HB., et al. 2020. Eur J Pharmacol. 874: 173023. PMID: 32087256
- Z-Guggulsterone alleviated oxidative stress and inflammation through inhibiting the TXNIP/NLRP3 axis in ischemic stroke. | Liu, T., et al. 2020. Int Immunopharmacol. 89: 107094. PMID: 33129097
- Z-Guggulsterone Induces Apoptosis in Gastric Cancer Cells through the Intrinsic Mitochondria-Dependent Pathway. | Lv, R., et al. 2021. ScientificWorldJournal. 2021: 3152304. PMID: 33488300
- Z-guggulsterone induces PD-L1 upregulation partly mediated by FXR, Akt and Erk1/2 signaling pathways in non-small cell lung cancer. | Tian, H., et al. 2021. Int Immunopharmacol. 93: 107395. PMID: 33529916
- Z-Guggulsterone alleviates renal fibrosis by mitigating G2/M cycle arrest through Klotho/p53 signaling. | Liu, M., et al. 2022. Chem Biol Interact. 354: 109846. PMID: 35123992
- Z-Guggulsterone Relieves Neuropathic Pain by Inhibiting the Expression of Astrocytes and Proinflammatory Cytokines in the Spinal Dorsal Horn. | Dang, SJ., et al. 2022. J Pain Res. 15: 1315-1324. PMID: 35546904
- Z-Guggulsterone attenuates cognitive defects and decreases neuroinflammation in APPswe/PS1dE9 mice through inhibiting the TLR4 signaling pathway. | Liu, J., et al. 2022. Biochem Pharmacol. 202: 115149. PMID: 35714682
- Z-Guggulsterone Is a Potential Lead Molecule of Dawa-ul-Kurkum against Hepatocellular Carcinoma. | Gupta, M., et al. 2022. Molecules. 27: PMID: 36014345
Inhibitor of:
FXR, GR, Maltase-glucoamylase, NF-1X, NFκB p65, and nPKC η.Activator of:
AR, PTP22, and Tollip.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Z-Guggulsterone, 5 mg | sc-204414B | 5 mg | $193.00 | |||
Z-Guggulsterone, 10 mg | sc-204414 | 10 mg | $369.00 | |||
Z-Guggulsterone, 25 mg | sc-204414A | 25 mg | $733.00 |