StIP1 Activators
The category of StIP1 Activators includes a diverse range of chemicals that function through different mechanisms and pathways to indirectly modulate the activity of StIP1. StIP1, or stress-induced phosphoprotein 1, is a co-chaperone that works alongside heat shock proteins like HSP90. It plays a crucial role in the regulation of cellular stress responses and protein homeostasis.
In the general sense, StIP1 is a protein involved in cellular processes, activators of such a protein are chemicals that enhance its biological activity. Direct activators typically bind to the protein and induce a conformational change that increases its activity. This could involve stabilizing the protein in an active form, promoting its interaction with substrates or other proteins, or preventing its deactivation. Indirect activators might work by increasing the expression levels of the protein, stabilizing its mRNA, enhancing its translation, or inhibiting proteins that negatively regulate it.
Items 1 to 10 of 12 total
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Rapamycin | 53123-88-9 | sc-3504 sc-3504A sc-3504B | 1 mg 5 mg 25 mg | $63.00 $158.00 $326.00 | 233 | |
Rapamycin is a potent and specific mTOR inhibitor. Inhibition of mTOR can lead to the activation of the HSP90-HOP-StIP1 complex, as mTOR inhibition stimulates the association of these proteins. | ||||||
Geldanamycin | 30562-34-6 | sc-200617B sc-200617C sc-200617 sc-200617A | 100 µg 500 µg 1 mg 5 mg | $39.00 $59.00 $104.00 $206.00 | 8 | |
Geldanamycin is an HSP90 inhibitor. Inhibition of HSP90 can lead to increased activity of StIP1, as StIP1 is a co-chaperone of HSP90 and its activity is enhanced when HSP90 is inhibited. | ||||||
17-AAG | 75747-14-7 | sc-200641 sc-200641A | 1 mg 5 mg | $67.00 $156.00 | 16 | |
17-AAG is another HSP90 inhibitor. It can increase the activity of StIP1 by inhibiting HSP90, with which StIP1 forms a co-chaperone complex. | ||||||
Cyclosporin A | 59865-13-3 | sc-3503 sc-3503-CW sc-3503A sc-3503B sc-3503C sc-3503D | 100 mg 100 mg 500 mg 10 g 25 g 100 g | $63.00 $92.00 $250.00 $485.00 $1035.00 $2141.00 | 69 | |
Cyclosporin A is an inhibitor of calcineurin, a protein phosphatase that can dephosphorylate StIP1. Inhibition of calcineurin can lead to increased phosphorylation and activation of StIP1. | ||||||
FK-506 | 104987-11-3 | sc-24649 sc-24649A | 5 mg 10 mg | $78.00 $151.00 | 9 | |
FK506 is another inhibitor of calcineurin. It can increase the phosphorylation and activity of StIP1 by inhibiting calcineurin. | ||||||
KN-93 | 139298-40-1 | sc-202199 | 1 mg | $182.00 | 25 | |
KN-93 is a selective inhibitor of CaMKII, which is known to phosphorylate StIP1. Inhibition of CaMKII can increase the phosphorylation and activity of StIP1. | ||||||
Trichostatin A | 58880-19-6 | sc-3511 sc-3511A sc-3511B sc-3511C sc-3511D | 1 mg 5 mg 10 mg 25 mg 50 mg | $152.00 $479.00 $632.00 $1223.00 $2132.00 | 33 | |
Trichostatin A is an inhibitor of histone deacetylases (HDACs). Inhibition of HDACs can lead to increased acetylation and activation of StIP1. | ||||||
Suberoylanilide Hydroxamic Acid | 149647-78-9 | sc-220139 sc-220139A | 100 mg 500 mg | $133.00 $275.00 | 37 | |
SAHA is another HDAC inhibitor. It can increase the acetylation and activity of StIP1 by inhibiting HDACs. | ||||||
C646 | 328968-36-1 | sc-364452 sc-364452A | 10 mg 50 mg | $265.00 $944.00 | 5 | |
C646 is a selective inhibitor of p300/CBP, histone acetyltransferases that can acetylate StIP1. Inhibition of p300/CBP can lead to increased acetylation and activation of StIP1. | ||||||
Anacardic Acid | 16611-84-0 | sc-202463 sc-202463A | 5 mg 25 mg | $102.00 $204.00 | 13 | |
Anacardic Acid is another inhibitor of p300/CBP. It can increase the acetylation and activity of StIP1 by inhibiting p300/CBP. | ||||||