RNase HII-C Activators
RNase HII-C Activators can be understood as chemicals that indirectly influence the activity of RNase HII-C, also known as RNASEH2C, a protein involved in the removal of RNA-DNA hybrids, critical for maintaining genome stability. These compounds generally function by causing replication stress or DNA damage, thereby increasing the formation of RNA-DNA hybrids, which RNASEH2C is involved in resolving. For instance, hydroxyurea and aphidicolin can induce replication stress, thereby leading to an increase in RNA-DNA hybrids. Similarly, 5-fluorouracil, gemcitabine, azidothymidine, tenofovir, and fludarabine, by getting incorporated into DNA, can cause disruption in the DNA structure and replication stress, thereby potentially increasing the formation of RNA-DNA hybrids.
Moreover, methotrexate, by inhibiting folate metabolism, can lead to dNTP pool imbalance, which can increase RNA-DNA hybrid formation. Similarly, etoposide, cisplatin, doxorubicin, and camptothecin, by causing DNA damage, can potentially increase RNA-DNA hybrid formation. Therefore, while none of these chemicals directly activate RNASEH2C, they can indirectly influence its activity by increasing the formation of RNA-DNA hybrids, which RNASEH2C is involved in resolving.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Hydroxyurea | 127-07-1 | sc-29061 sc-29061A | 5 g 25 g | $78.00 $260.00 | 18 | |
Hydroxyurea can indirectly influence RNASEH2C by inducing replication stress, leading to an increase in RNA-DNA hybrids which RNASEH2C is involved in resolving. | ||||||
Aphidicolin | 38966-21-1 | sc-201535 sc-201535A sc-201535B | 1 mg 5 mg 25 mg | $84.00 $306.00 $1104.00 | 30 | |
Aphidicolin can indirectly influence RNASEH2C by inhibiting DNA polymerase, leading to replication stress and increased formation of RNA-DNA hybrids. | ||||||
Fluorouracil | 51-21-8 | sc-29060 sc-29060A | 1 g 5 g | $37.00 $152.00 | 11 | |
5-Fluorouracil can indirectly influence RNASEH2C by being incorporated into RNA and DNA, causing disruption in the DNA structure and potentially increasing the formation of RNA-DNA hybrids. | ||||||
Methotrexate | 59-05-2 | sc-3507 sc-3507A | 100 mg 500 mg | $94.00 $213.00 | 33 | |
Methotrexate can indirectly influence RNASEH2C by inhibiting folate metabolism, leading to dNTP pool imbalance, which can increase RNA-DNA hybrid formation. | ||||||
2′-Deoxy-2′,2′-difluorocytidine | 95058-81-4 | sc-275523 sc-275523A | 1 g 5 g | $56.00 $128.00 | ||
Gemcitabine can indirectly influence RNASEH2C by getting incorporated into DNA, leading to stalling of replication forks and potentially increasing RNA-DNA hybrid formation. | ||||||
Etoposide (VP-16) | 33419-42-0 | sc-3512B sc-3512 sc-3512A | 10 mg 100 mg 500 mg | $51.00 $231.00 $523.00 | 63 | |
Etoposide can indirectly influence RNASEH2C by inhibiting topoisomerase II, leading to DNA damage and potentially increasing RNA-DNA hybrid formation. | ||||||
Cisplatin | 15663-27-1 | sc-200896 sc-200896A | 100 mg 500 mg | $138.00 $380.00 | 101 | |
Cisplatin can indirectly influence RNASEH2C by causing DNA damage, leading to replication stress and potentially increased RNA-DNA hybrid formation. | ||||||
Doxorubicin | 23214-92-8 | sc-280681 sc-280681A | 1 mg 5 mg | $176.00 $426.00 | 43 | |
Doxorubicin can indirectly influence RNASEH2C by intercalating into DNA, causing DNA damage and potentially increasing RNA-DNA hybrid formation. | ||||||
Camptothecin | 7689-03-4 | sc-200871 sc-200871A sc-200871B | 50 mg 250 mg 100 mg | $58.00 $186.00 $94.00 | 21 | |
Camptothecin can indirectly influence RNASEH2C by inhibiting topoisomerase I, leading to DNA damage and potentially increased RNA-DNA hybrid formation. | ||||||
3′-Azido-3′-deoxythymidine | 30516-87-1 | sc-203319 | 10 mg | $61.00 | 2 | |
Azidothymidine can indirectly influence RNASEH2C by being incorporated into DNA, causing replication stress and potentially increasing RNA-DNA hybrid formation. | ||||||