IL-22Rα2 Activators
The chemicals listed primarily function by modulating the IL-22 signaling pathway and related immune responses. By influencing IL-22 activity and availability, these compounds indirectly affect the role of IL-22Rα2 as a soluble decoy receptor. JAK inhibitors and STAT3 inhibitors target key molecules in the IL-22 signaling cascade, potentially altering the pathway's activation and the downstream effects mediated by IL-22Rα2. These inhibitors can modulate the response to IL-22, thereby influencing how IL-22Rα2 regulates this cytokine's availability and activity.
Natural compounds like Curcumin, Resveratrol, Vitamin D3, Omega-3 Fatty Acids, and Quercetin are known for their anti-inflammatory properties and their ability to modulate immune responses. Their effects on cytokine signaling, including the IL-22 pathway, can indirectly influence the regulatory dynamics between IL-22 and IL-22Rα2. Pharmacological agents such as Thalidomide, Sulfasalazine, Methotrexate, and Azathioprine, used in managing autoimmune and inflammatory conditions, can affect cytokine production and signaling. Their potential impact on IL-22 signaling pathways may indirectly modulate the role of IL-22Rα2 in immune regulation. These compounds, through their diverse actions on cytokine signaling pathways, provide insights into potential mechanisms of modulating the IL-22/IL-22Rα2 interaction, highlighting the complex interplay in cytokine regulation and immune response modulation.
SEE ALSO...
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Stat3 inhibitor V, stattic | 19983-44-9 | sc-202818 sc-202818A sc-202818B sc-202818C sc-202818D sc-202818E sc-202818F | 25 mg 100 mg 250 mg 500 mg 1 g 2.5 g 5 g | $130.00 $196.00 $274.00 $512.00 $731.00 $1408.00 $2091.00 | 114 | |
STAT3 inhibitors target the Signal Transducer and Activator of Transcription 3, a critical molecule in the IL-22 signaling pathway. By inhibiting STAT3, these compounds can disrupt the signaling cascade initiated by IL-22, potentially influencing the functional dynamics of IL-22Rα2 in cytokine regulation. | ||||||
Curcumin | 458-37-7 | sc-200509 sc-200509A sc-200509B sc-200509C sc-200509D sc-200509F sc-200509E | 1 g 5 g 25 g 100 g 250 g 1 kg 2.5 kg | $37.00 $69.00 $109.00 $218.00 $239.00 $879.00 $1968.00 | 47 | |
Curcumin, a compound found in turmeric, has been shown to modulate various signaling pathways, including those involved in inflammation and cytokine signaling. Its effect on the IL-22 pathway could indirectly impact the regulation of this pathway by IL-22Rα2. | ||||||
Resveratrol | 501-36-0 | sc-200808 sc-200808A sc-200808B | 100 mg 500 mg 5 g | $80.00 $220.00 $460.00 | 64 | |
Resveratrol is a polyphenol with anti-inflammatory properties. It may modulate cytokine signaling pathways, including IL-22, thereby potentially affecting the interaction dynamics between IL-22 and IL-22Rα2. | ||||||
Cholecalciferol | 67-97-0 | sc-205630 sc-205630A sc-205630B | 1 g 5 g 10 g | $71.00 $163.00 $296.00 | 2 | |
Cholecalciferol can modulate immune responses and cytokine production. Its influence on IL-22 production or signaling could indirectly affect the regulatory role of IL-22Rα2 in immune responses. | ||||||
Thalidomide | 50-35-1 | sc-201445 sc-201445A | 100 mg 500 mg | $111.00 $357.00 | 8 | |
Thalidomide and its derivatives are immunomodulatory compounds that can affect various cytokine signaling pathways. Their potential impact on IL-22 signaling could indirectly influence the role of IL-22Rα2 in immune responses. | ||||||
Sulfasalazine | 599-79-1 | sc-204312 sc-204312A sc-204312B sc-204312C | 1 g 2.5 g 5 g 10 g | $61.00 $77.00 $128.00 $209.00 | 8 | |
Sulfasalazine has been shown to affect cytokine production. Its influence on IL-22 signaling could indirectly modify the interaction between IL-22 and IL-22Rα2. | ||||||
Methotrexate | 59-05-2 | sc-3507 sc-3507A | 100 mg 500 mg | $94.00 $213.00 | 33 | |
Methotrexate, studied in the research of various autoimmune diseases, can modulate cytokine production and response. Its effect on IL-22 signaling may indirectly impact IL-22Rα2's regulatory role. | ||||||
Quercetin | 117-39-5 | sc-206089 sc-206089A sc-206089E sc-206089C sc-206089D sc-206089B | 100 mg 500 mg 100 g 250 g 1 kg 25 g | $11.00 $17.00 $110.00 $250.00 $936.00 $50.00 | 33 | |
Quercetin is a flavonoid with anti-inflammatory properties, known to modulate various cytokine signaling pathways. Its potential effects on IL-22 signaling could indirectly influence IL-22Rα2 function. | ||||||
Azathioprine | 446-86-6 | sc-210853D sc-210853 sc-210853A sc-210853B sc-210853C | 500 mg 1 g 2 g 5 g 10 g | $203.00 $176.00 $349.00 $505.00 $704.00 | 1 | |
Azathioprine, an immunosuppressive compound, may affect various cytokine pathways, including IL-22 signaling. Its impact on this pathway could indirectly modulate the role of IL-22Rα2 in immune regulation. | ||||||