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Sulfasalazine is an antiinflammatory agent that inhibits GSH-H-transferase. Sulfasalazine largely inhibits NF-κB activation and induces apoptosis in T-lymphocytes. The compound also engages neutrophil apoptosis that can be abrogated by Tyr-K inhibitors, PKA inhibitors, or antioxidants. Sulfasalazine is shown to inhibit basic fibroblast growth factor-induced endothelial cell chemotaxis. Sulfasalazine is an inhibitor of TNFα and an activator of PPARγ.
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See how others have used Sulfasalazine. Click on the entry to view the PubMed entry .
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PMID: # 28630042 Koppula, P. et al. 2017. J. Biol. Chem.
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