Molecular structure of Azathioprine, CAS Number: 446-86-6
Azathioprine (CAS 446-86-6)
See product citations (1)
Alternate Names:
6-(1-Methyl-4-nitroimidazol-5-yl)thiopurine
Application:
Azathioprine is an immunosuppressive antimetabolite that interferes with the synthesis of purines
CAS Number:
446-86-6
Molecular Weight:
277.26
Molecular Formula:
C9H7N7O2S
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
QUICK LINKS
Ordering Information
Product Citations
Description
Technical Information
Safety Information
SDS & Certificate of Analysis
Azathioprine is a purine analogue that inhibits the synthesis of DNA, RNA, and proteins. Azathioprine converted to 6-mercaptopurine, which interferes with the proliferation of immune cells. Azathioprine is used as an immunosuppressant. It works by suppressing the immune system. Its effects can be influenced by genetic variations in the enzymes involved in its metabolism.
Azathioprine (CAS 446-86-6) References
- Analysis of gene mutations and clastogenicity following short-term treatment with azathioprine in MutaMouse. | Smith, CC., et al. 1999. Environ Mol Mutagen. 34: 131-9. PMID: 10529737
- Comparative scoring of micronucleated reticulocytes in rat peripheral blood by flow cytometry and microscopy. | Torous, DK., et al. 2003. Toxicol Sci. 74: 309-14. PMID: 12773756
- Lymphocyte Hprt mutant frequency and sperm toxicity in C57BL/6 mice treated chronically with Azathioprine. | Bendre, SV., et al. 2005. Mutat Res. 578: 1-14. PMID: 16107271
- Effect of chronic azathioprine treatment on germ-line transmission of Hprt mutation in mice. | Bendre, SV., et al. 2007. Environ Mol Mutagen. 48: 744-53. PMID: 18008354
- Mechanism-based selection of compounds for the development of innovative in vitro approaches to hepatotoxicity studies in the LIINTOP project. | Gómez-Lechón, MJ., et al. 2010. Toxicol In Vitro. 24: 1879-89. PMID: 20656008
- Azathioprine-induced fever in autoimmune hepatitis. | Khoury, T., et al. 2013. World J Gastroenterol. 19: 4083-6. PMID: 23840156
- Classification of hepatotoxicants using HepG2 cells: A proof of principle study. | Van den Hof, WF., et al. 2014. Chem Res Toxicol. 27: 433-42. PMID: 24437676
- Effective long-term solution to therapeutic remission in Inflammatory Bowel Disease: Role of Azathioprine. | Adam, L., et al. 2018. Biomed Pharmacother. 100: 8-14. PMID: 29421584
- Azathioprine in combination with methotrexate: a therapeutic alternative in severe and recalcitrant forms of alopecia areata? | Mascia, P., et al. 2019. J Eur Acad Dermatol Venereol. 33: e494-e495. PMID: 31374131
- Kinetics of γH2AX and phospho-histone H3 following pulse treatment of TK6 cells provides insights into clastogenic activity. | Bryce, SM., et al. 2021. Mutagenesis. 36: 255-264. PMID: 33964157
- Redox Mechanism of Azathioprine and Its Interaction with DNA. | Bunea, MC., et al. 2021. Int J Mol Sci. 22: PMID: 34202734
- The in vitro micronucleus test on isolated human lymphocytes. | Vian, L., et al. 1993. Mutat Res. 291: 93-102. PMID: 7678919
- Experimental data and thermodynamic modeling of solubility of Azathioprine, as an immunosuppressive and anti-cancer drug, in supercritical carbon dioxide | Sodeifian, G., Razmimanesh, F., Ardestani, N. S., & Sajadian, S. A. 2020. Journal of Molecular Liquids. 299: 112179.
Inhibitor of:
α-defensin 1B, β-defensin 1, β-defensin 118, β-defensin 119, β-defensin 123, β-defensin 124, β-defensin 125, β-defensin 126, β-defensin 3, 9530053A07Rik, ACY1L2, AICAR transformylase, AMT, APRT, Atase, ATHL1, AUH, BAT5, BDV, BTN2A1, BTN3A1, BTN3A2, BTN3A3, C10orf72, C12orf62, C13orf31, C14orf115, C14orf147, C1QBP, C4 A, C4b, CADM1 (Cell Adhesion Molecule 1), CD16, CD163L1, CD1C, CD3-ζ, CD8α, COL3A1, Collagen α2 Type VI, CRISP-8, cryptdin 13, cryptdin 15, CTPS1, Dectin-2, DNAM-1, DPYS, ENOPH1, Esp3, F5 TCR α, F5 TCR β, FcRH4, Fcrls, FGAM Synthase, GlyRS, Gm11062, Gm13247, GMPPB, GMPR2, GMPS, GNMT, GRAIL, GSH-2, GUCD1, HLA-DR, HPRT, IFIT1L, IFN-α12, IFRD2, IgA, IgA chain C, IgA2, Igbp1b, IgE Chain C, IgG, IgG κ light chain, IgG λ light chain, IgG Fab fragment, IgG1, IgG2, IgG2a, IgG3, IgG4, IgH-VJ558, IgHg, IL-12A p35, IL-1R8, IL-2Rα, ILT-11, ILT-2, Integrin X, IRF-6, IRF-8, ISYNA1, ITI-H3, KIR2DL1, KIR3DL3, Klra22, LACC1, Leukocyte Marker, Ly-49C, Ly-49G, Ly-49N, Ly6G6e, MAT IIα, MHC, MIC2, MIF4GD, Might chain, MNSF-β, MSR, NKG2-E, NKp46, NT5DC1, Nucleoside Monophosphate Kinase, Olr203, OSGEPL1, OTTMUSG00000015050, OTTMUSG00000017373, OTTMUSG00000019784, OX2, PCDHB12, PIG-YL, PLA2R, PPC Synthetase, PROSC, PRPS1, PRPS1L1, PRPS2, PRPSAP2, PRTFDC1, QTRT1, rat thymocytes, bone marrow, RCL, Rheumatoid Factor, Rpp21, Rpp38, RT1-Ac, RT1-Bα, Scrib, Sectm1a, Serglycin, SerRSmt, Siglec-1, Siglec-11, Skint1, Skint5, Skint6, Skint8, SLAMF6, SlfnL1, SMC3, SPINK9, SUSD4, T Cell Marker, T-cell receptor Vδ 2, TCR δ, TCR V γ 3, Thioguanine, TIM-2, TPO, Trav12n-1, Trav6d-5, Trav8d-1, TSARG2, TTL, UPase 2, UPRT, WC1, and ZNF262.Activator of:
γ-GCSc, 5′-nucleotidase, ADK, BAF57, Bu-1a, C19orf21, CD137L, CD3-ε, CD6, CTPS1, Cypin, DOCK 2, EBV Ea-R p85, Fc ε RIγ, FCRLM1, Forssman Antigen, GIMAP4, GIMAP5, HISPPD2A, Ig κ chain, Ig λ chain, IL-17E, IL-1F9, IL-1RII, IL-21R, IL-22Rα2, IL-31, IL-31R, ITPase, LAIR-1, MBNL1, MHC class II DQ, MIP-4, NT5C3, NUDT15, Pdcd-1L2, PI-9, RELL2, Respiratory Syncytial Virus, Ribosomal Protein L10a, Ribosomal Protein L24, Ribosomal Protein S19, SH2D1A, Siglec-7, SIRP-δ, SKAP55-R, Slfn1, TPN, TREML4, UMPS, URO-9, and ZNF425.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Azathioprine, 500 mg | sc-210853D | 500 mg | $199.00 | |||
Azathioprine, 1 g | sc-210853 | 1 g | $173.00 | |||
Azathioprine, 2 g | sc-210853A | 2 g | $342.00 | |||
Azathioprine, 5 g | sc-210853B | 5 g | $495.00 | |||
Azathioprine, 10 g | sc-210853C | 10 g | $690.00 |