FucT-l Activators
FucT-l activators represent a class of chemical agents that target the enzyme FucT-l, formally known as fucosyltransferase 1, which catalyzes the addition of fucose, a hexose deoxy sugar, to glycoproteins and glycolipids through an alpha-1,2 glycosidic bond. This enzymatic activity is crucial in the synthesis of H antigens, which are precursors to the ABO blood group antigens and have roles in cell adhesion and signal transduction.
Activators of FucT-l may operate via direct or indirect approaches to enhance the enzyme's catalytic function. Direct activators might interact with the enzyme's active site or allosteric sites, promoting a conformational change that increases its affinity for substrates or its catalytic efficiency. This interaction could mimic the natural allosteric regulation by the cell's own metabolites or by modifying the enzyme's structure to a more active form. Indirect activators of FucT-l could operate by increasing the transcription of the FUT1 gene that encodes FucT-l, by stabilizing its mRNA, or by inhibiting the degradation of the enzyme, thereby raising its levels within the cell. Alternatively, they might affect the cellular levels of substrates or cofactors necessary for the enzyme's activity, such as GDP-fucose, the fucosyl donor. They could also modulate the activity of signaling pathways that impact the enzyme's post-translational modifications, which can be critical for its localization, stability, and interaction with substrates.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
N-Acetyl-D-glucosamine | 7512-17-6 | sc-286377 sc-286377B sc-286377A | 50 g 100 g 250 g | $94.00 $162.00 $306.00 | 1 | |
UDP-GlcNAc is a substrate for O-GlcNAc transferase (OGT). OGT modifies proteins post-translationally by adding O-GlcNAc, which can enhance the activity of FucT-l by providing the necessary substrate for its action. | ||||||
(Z)-Pugnac | 132489-69-1 | sc-204415A sc-204415 | 5 mg 10 mg | $224.00 $380.00 | 3 | |
PUGNAc is an inhibitor of O-GlcNAcase (OGA), the enzyme that removes O-GlcNAc from proteins. Its inhibition leads to increased O-GlcNAcylation, providing more substrate for FucT-l to act on. | ||||||
Thiamet G | 1009816-48-1 | sc-224307 sc-224307A | 1 mg 5 mg | $52.00 $96.00 | 1 | |
Thiamet G is another OGA inhibitor, leading to increased O-GlcNAcylation and, consequently, a greater substrate for FucT-l. | ||||||
TC-A 2317 hydrochloride | 1245907-03-2 | sc-363291 sc-363291A | 10 mg 50 mg | $218.00 $988.00 | ||
This compound enhances the production of sialic acid, which can be used by FucT-l as a substrate for the synthesis of complex carbohydrates. | ||||||
N-Acetylneuraminic acid | 131-48-6 | sc-281055A sc-281055 sc-281055D sc-281055B sc-281055C | 1 g 5 g 25 g 100 g 250 g | $84.00 $156.00 $326.00 $572.00 $1363.00 | ||
Neu5Ac is a form of sialic acid that stands as a substrate for FucT-l in the synthesis of complex carbohydrates. | ||||||
2-Deoxy-D-glucose | 154-17-6 | sc-202010 sc-202010A | 1 g 5 g | $70.00 $215.00 | 26 | |
This compound leads to increased O-GlcNAcylation, providing more substrate for FucT-l action. | ||||||
Butyric acid | 107-92-6 | sc-214640 sc-214640A | 1 kg 10 kg | $64.00 $177.00 | ||
Butyrate is a histone deacetylase inhibitor that can lead to increased histone acetylation and open chromatin structure, potentially leading to enhanced FucT-l activity. | ||||||
Sodium phenylbutyrate | 1716-12-7 | sc-200652 sc-200652A sc-200652B sc-200652C sc-200652D | 1 g 10 g 100 g 1 kg 10 kg | $77.00 $166.00 $622.00 $5004.00 $32783.00 | 43 | |
Sodium Phenylbutyrate is another histone deacetylase inhibitor that can potentially enhance FucT-l activity by opening the chromatin structure. | ||||||
5-Azacytidine | 320-67-2 | sc-221003 | 500 mg | $280.00 | 4 | |
Azacitidine is a DNA methyltransferase inhibitor that can lead to reduction in DNA methylation, potentially leading to increased FucT-l activity by loosening chromatin structure. | ||||||
5-Aza-2′-Deoxycytidine | 2353-33-5 | sc-202424 sc-202424A sc-202424B | 25 mg 100 mg 250 mg | $218.00 $322.00 $426.00 | 7 | |
Decitabine is another DNA methyltransferase inhibitor that can potentially enhance FucT-l activity by reducing DNA methylation and thereby opening chromatin structure. | ||||||