Molecular structure of TC-A 2317 hydrochloride, CAS Number: 1245907-03-2
TC-A 2317 hydrochloride (CAS 1245907-03-2)
Alternate Names:
2-[(6-hydroxy-6-methylheptan-2-yl)amino]-4-methyl-6-[(5-methyl-1H-pyrazol-3-yl)amino]pyridine-3-carbonitrile;hydrochloride
Application:
TC-A 2317 hydrochloride is a potent and selective Ark-1 inhibitor
CAS Number:
1245907-03-2
Molecular Weight:
392.93
Molecular Formula:
C19H28N6O•HCl
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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Description
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SDS & Certificate of Analysis
Potent Aurora kinase A inhibitor (Ki = 1.2 nM compared to 101 nM for inhibition of Aurora kinase B). Selective over 60 other kinases (IC50 values > 1000 nM). Exhibits good cell permeability and antitumor activity.
TC-A 2317 hydrochloride (CAS 1245907-03-2) References
- 3-Cyano-6-(5-methyl-3-pyrazoloamino)pyridines: selective Aurora A kinase inhibitors. | Ando, R., et al. 2010. Bioorg Med Chem Lett. 20: 4709-11. PMID: 20573509
- The Aurora kinase inhibitors in cancer research and therapy. | Cicenas, J. 2016. J Cancer Res Clin Oncol. 142: 1995-2012. PMID: 26932147
- Aurora Kinase Inhibitors in Head and Neck Cancer. | Qi, G., et al. 2018. Curr Top Med Chem. 18: 199-213. PMID: 29332580
- Mitosis inhibitors in anticancer therapy: When blocking the exit becomes a solution. | Henriques, AC., et al. 2019. Cancer Lett. 440-441: 64-81. PMID: 30312726
- The therapeutic potential of Aurora kinases targeting in glioblastoma: from preclinical research to translational oncology. | de Almeida Magalhães, T., et al. 2020. J Mol Med (Berl). 98: 495-512. PMID: 32219470
Inhibitor of:
ARK-1, and IRS-1.Activator of:
FucT-l.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
TC-A 2317 hydrochloride, 10 mg | sc-363291 | 10 mg | $214.00 | |||
TC-A 2317 hydrochloride, 50 mg | sc-363291A | 50 mg | $969.00 |