Date published: 2026-7-12

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SREBP Antibodies

Santa Cruz Biotechnology supplies a comprehensive collection of SREBP monoclonal antibodies for advanced research in lipid metabolism and cellular regulation. SREBP Antibodies are compatible with multiple research applications, including western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry with paraffin-embedded sections (IHCP), flow cytometry (FCM), and enzyme-linked immunosorbent assay (ELISA). Sterol regulatory element-binding proteins (SREBPs) play a crucial role in the regulation of cholesterol and fatty acid synthesis, maintaining cellular lipid homeostasis. Dysregulation of SREBP activity has been linked to various metabolic disorders, including obesity and cardiovascular diseases. Understanding SREBP function is essential for developing new therapeutic strategies targeting lipid-related diseases. Researchers can explore the molecular mechanisms of SREBP activation and its downstream effects on gene expression. Advanced imaging techniques combined with SREBP monoclonal antibodies enable visualization of protein localization and trafficking within cells. Investigating SREBP-mediated pathways provides valuable insights into metabolic regulation and potential therapeutic interventions. Santa Cruz Biotechnology monoclonal antibodies for SREBP research support scientists worldwide in advancing our understanding of lipid metabolism and its impact on human health.

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SREBP Antibodies

Empty Table HeaderProduct NameCATALOG #ISOTYPEEPITOPEAPPLICATIONSSpeciesCitationsRATING

SREBP-1 Antibody (A-4)

sc-365513mouse IgG1 κ1119-1147 (h)WB, IP, IF, IHC(P), ELISAm, r, h
119
(31)

SREBP-1 Antibody (2A4)

sc-13551mouse IgG1 κ301-407 (h)WB, IP, IF, IHC(P)m, r, h, hamster
380
(35)

SREBP-1 Antibody (E-4)

sc-17755mouse IgG2b κ41-200 (h)WB, IP, IF, IHC(P), ELISAm, r, h
15
(8)

SREBP-1 Antibody (3F335)

sc-73058mouse IgG1 κ301-407 (h)WB, IPm, r, h, hamster
1
(1)

SREBP-1 Antibody (F-10)

sc-365514mouse IgG3 κ1119-1147 (h)WB, IP, IF, IHC(P), ELISAm, r, h
9
(3)

SREBP-2 Antibody (1C6)

sc-13552mouse IgG1 κ833-1141 (h)WB, IP, IFm, r, h
80
(25)

SREBP-2 Antibody (A-12)

sc-271616mouse IgG2a κ812-975 (h)WB, IP, IF, IHC(P), ELISAm, r, h
15
(9)

SREBP-2 Antibody (C-6)

sc-271615mouse IgG2a κ812-975 (h)WB, IP, IF, IHC(P), ELISAm, r, h
12
(2)

SREBP siRNA, shRNA Plasmid and shRNA Lentiviral Particle Gene Silencers

Empty Table HeaderProduct NameCATALOG #SpeciesAPPLICATIONSMARKERCitationsRATING

SREBP-1 siRNA (h)

sc-36557hGene SilencingN/A
24
(0)

SREBP-1 siRNA (h2)

sc-44327hGene SilencingN/A
2
(0)

SREBP-1 shRNA Plasmid (h)

sc-36557-SHhGene SilencingPuromycin
24
(0)

SREBP-1 shRNA Plasmid (h2)

sc-44327-SHhGene SilencingPuromycin
2
(0)

SREBP-1 shRNA (h) Lentiviral Particles

sc-36557-VhGene SilencingPuromycin
24
(0)

SREBP-1 shRNA (h2) Lentiviral Particles

sc-44327-VhGene SilencingPuromycin
2
(0)

SREBP-1 siRNA (m)

sc-36558mGene SilencingN/A
8
(0)

SREBP-1 shRNA Plasmid (m)

sc-36558-SHmGene SilencingPuromycin
8
(0)

SREBP-1 shRNA (m) Lentiviral Particles

sc-36558-VmGene SilencingPuromycin
8
(0)

SREBP-1 siRNA (r)

sc-156126rGene SilencingN/A0
(0)

SREBP-1 shRNA Plasmid (r)

sc-156126-SHrGene SilencingPuromycin0
(0)

SREBP-1 shRNA (r) Lentiviral Particles

sc-156126-VrGene SilencingPuromycin0
(0)

SREBP-2 siRNA (h)

sc-36559hGene SilencingN/A
11
(0)

SREBP-2 shRNA Plasmid (h)

sc-36559-SHhGene SilencingPuromycin
11
(0)

SREBP-2 shRNA (h) Lentiviral Particles

sc-36559-VhGene SilencingPuromycin
11
(0)

SREBP-2 siRNA (m)

sc-36560mGene SilencingN/A0
(0)

SREBP-2 shRNA Plasmid (m)

sc-36560-SHmGene SilencingPuromycin0
(0)

SREBP-2 shRNA (m) Lentiviral Particles

sc-36560-VmGene SilencingPuromycin0
(0)

SREBP CRISPR Knockout (KO) and HDR Plasmids

Empty Table HeaderProduct NameCATALOG #APPLICATIONSSpeciesCitationsRATING

SREB1 CRISPR/Cas9 KO Plasmid (m)

sc-420652Gene Knockoutm0
(0)

SREB1 HDR Plasmid (m)

sc-420652-HDRHomology Directed Repairm0
(0)

SREBP-1 CRISPR/Cas9 KO Plasmid (h2)

sc-400094-KO-2Gene Knockouth0
(0)

SREBP-1 HDR Plasmid (h2)

sc-400094-HDR-2Homology Directed Repairh0
(0)

SREBP-1 CRISPR/Cas9 KO Plasmid (m)

sc-423152Gene Knockoutm0
(0)

SREBP-2 CRISPR/Cas9 KO Plasmid (h2)

sc-400575-KO-2Gene Knockouth0
(0)

SREBP-2 HDR Plasmid (h2)

sc-400575-HDR-2Homology Directed Repairh0
(0)

SREBP-2 CRISPR/Cas9 KO Plasmid (m)

sc-423153Gene Knockoutm0
(0)

SREBP-2 HDR Plasmid (m)

sc-423153-HDRHomology Directed Repairm0
(0)

SREBP CRISPR Double Nickase Plasmids

Empty Table HeaderProduct NameCATALOG #APPLICATIONSSpeciesCitationsRATING

SREBP-1 Double Nickase Plasmid (h)

sc-400094-NICGene Knockouth0
(0)

SREBP-1 Double Nickase Plasmid (h2)

sc-400094-NIC-2Gene Knockouth0
(0)

SREBP-1 Double Nickase Plasmid (m)

sc-423152-NICGene Knockoutm0
(0)

SREBP-2 Double Nickase Plasmid (h)

sc-400575-NICGene Knockouth0
(0)

SREBP-2 Double Nickase Plasmid (h2)

sc-400575-NIC-2Gene Knockouth0
(0)

SREBP CRISPR Activation Plasmids and Lentiviral Particles

Empty Table HeaderProduct NameCATALOG #APPLICATIONSSpeciesCitationsRATING

SREBP-1 CRISPR Activation Plasmid (h)

sc-400094-ACTGene Activationh0
(0)

SREBP-1 CRISPR Activation Plasmid (h2)

sc-400094-ACT-2Gene Activationh0
(0)

SREBP-1 Lentiviral Activation Particles (h)

sc-400094-LACGene Activationh0
(0)

SREBP-1 Lentiviral Activation Particles (h2)

sc-400094-LAC-2Gene Activationh0
(0)

SREBP-1 CRISPR Activation Plasmid (m)

sc-423152-ACTGene Activationm0
(0)

SREBP-1 CRISPR Activation Plasmid (m2)

sc-423152-ACT-2Gene Activationm0
(0)

SREBP-2 CRISPR Activation Plasmid (h)

sc-400575-ACTGene Activationh0
(0)

SREBP-2 CRISPR Activation Plasmid (m)

sc-423153-ACTGene Activationm0
(0)

SREBP-2 CRISPR Activation Plasmid (m2)

sc-423153-ACT-2Gene Activationm0
(0)