SREBP-1 Antibody (E-4): sc-17755
- SREBP-1 Antibody (E-4) is a mouse monoclonal IgG2b κ, cited in 15 publications, provided at 200 µg/ml
- raised against amino acids 41-200 of SREBP-1 of human origin
- Anti-SREBP-1 Antibody (E-4) is recommended for detection of SREBP-1 of mouse, rat and human origin by WB, IP, IF, IHC(P) and ELISA
- Anti-SREBP-1 Antibody (E-4) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
- also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- TransCruz reagent for Gel Supershift and ChIP applications (sc-17755 X, 200 µg/0.1 ml)
- m-IgG Fc BP-HRP and m-IgG2b BP-HRP are the preferred secondary detection reagents for SREBP-1 Antibody (E-4) for WB and IHC(P) applications. These reagents are now offered in bundles with SREBP-1 Antibody (E-4) (see ordering information below).
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SREBP-1 Antibody (E-4) is a mouse monoclonal IgG2b kappa light chain antibody that detects SREBP-1 protein of mouse, rat, and human origin through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry (IHC), and enzyme-linked immunosorbent assay (ELISA). SREBP-1 (E-4) antibody is offered in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase, phycoerythrin, fluorescein isothiocyanate, and multiple Alexa Fluor® conjugates. SREBP-1 protein plays a crucial role in lipid metabolism by regulating the expression of genes involved in cholesterol and fatty acid synthesis. SREBP-1 protein is synthesized as a precursor that resides in the nuclear envelope and endoplasmic reticulum, and upon sterol depletion, undergoes proteolytic cleavage to release a soluble fragment that translocates to the nucleus, where SREBP-1 activates transcription of target genes, including the low-density lipoprotein receptor. This receptor is essential for the endocytic uptake of cholesterol-carrying lipoproteins, thereby maintaining cellular and plasma cholesterol levels. SREBP-1 regulation is vital for cellular homeostasis, as excessive cholesterol can lead to cellular dysfunction and contribute to diseases such as atherosclerosis.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
SREBP-1 Antibody (E-4) | sc-17755 | 200 µg/ml | $322.00 | |||
SREBP-1 Antibody (E-4): m-IgG Fc BP-HRP Bundle | sc-525483 | 200 µg Ab; 10 µg BP | $361.00 | |||
SREBP-1 Antibody (E-4): m-IgG2b BP-HRP Bundle | sc-549567 | 200 µg Ab; 10 µg BP | $361.00 | |||
SREBP-1 Antibody (E-4) X | sc-17755 X | 200 µg/0.1 ml | $322.00 | |||
SREBP-1 Antibody (E-4) AC | sc-17755 AC | 500 µg/ml, 25% agarose | $424.00 | |||
SREBP-1 Antibody (E-4) HRP | sc-17755 HRP | 200 µg/ml | $322.00 | |||
SREBP-1 Antibody (E-4) FITC | sc-17755 FITC | 200 µg/ml | $336.00 | |||
SREBP-1 Antibody (E-4) PE | sc-17755 PE | 200 µg/ml | $349.00 | |||
SREBP-1 Antibody (E-4) Alexa Fluor® 488 | sc-17755 AF488 | 200 µg/ml | $364.00 | |||
SREBP-1 Antibody (E-4) Alexa Fluor® 546 | sc-17755 AF546 | 200 µg/ml | $364.00 | |||
SREBP-1 Antibody (E-4) Alexa Fluor® 594 | sc-17755 AF594 | 200 µg/ml | $364.00 | |||
SREBP-1 Antibody (E-4) Alexa Fluor® 647 | sc-17755 AF647 | 200 µg/ml | $364.00 | |||
SREBP-1 Antibody (E-4) Alexa Fluor® 680 | sc-17755 AF680 | 200 µg/ml | $364.00 | |||
SREBP-1 Antibody (E-4) Alexa Fluor® 790 | sc-17755 AF790 | 200 µg/ml | $364.00 |