SREBP-1 Antibody (3F335): sc-73058
- SREBP-1 Antibody (3F335) is a mouse monoclonal IgG1 κ, cited in 1 publications, provided at 200 µg/ml
- raised against amino acids 301-407 of SREBP-1 of human origin
- recommended for detection of SREBP-1 of mouse, rat, human and hamster origin by WB and IP
- See SREBP-1 (A-4): sc-365513 for SREBP-1 antibody conjugates, including AC, HRP, FITC, PE, Alexa Fluor® 488, 594, 647, 680 and 790.
- m-IgG Fc BP-HRP and m-IgG1 BP-HRP are the preferred secondary detection reagents for SREBP-1 Antibody (3F335) for WB applications. These reagents are now offered in bundles with SREBP-1 Antibody (3F335) (see ordering information below).
SREBP-1 Antibody (3F335) is a mouse monoclonal IgG1 antibody that detects SREBP-1 in mouse, rat, human, and hamster samples through applications such as western blotting (WB) and immunoprecipitation (IP). SREBP-1, also known as adipocyte determination and differentiation factor 1, plays a crucial role in lipid metabolism by regulating the expression of genes involved in cholesterol and fatty acid synthesis. SREBP-1 is primarily located in the endoplasmic reticulum and the nuclear envelope, where SREBP-1 exists as a precursor form. Upon sterol depletion, SREBP-1 undergoes proteolytic cleavage, releasing a soluble fragment that translocates to the nucleus to activate transcription of target genes, thereby enhancing the uptake of low-density lipoprotein (LDL) and promoting lipid biosynthesis. The regulation of SREBP-1 is vital for maintaining cellular lipid homeostasis, as excessive cholesterol accumulation can lead to various metabolic disorders. Anti-SREBP-1 antibody (3F335) is an essential tool for researchers studying lipid metabolism and its implications in health and disease.
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
SREBP-1 Antibody (3F335) | sc-73058 | 200 µg/ml | $322.00 | |||
SREBP-1 Antibody (3F335): m-IgG Fc BP-HRP Bundle | sc-539446 | 200 µg Ab; 10 µg BP | $361.00 | |||
SREBP-1 Antibody (3F335): m-IgG1 BP-HRP Bundle | sc-541493 | 200 µg Ab; 20 µg BP | $361.00 |