RNGTT Inhibitors
RNGTT inhibitors is a distinct class of chemical compounds that exert their effects through specific interactions with the RNGTT protein. This class of inhibitors is characterized by their ability to modulate the activity of RNGTT, a key enzyme involved in various cellular processes. RNGTT, or RNA guanylyltransferase and 5'-phosphatase, plays a vital role in RNA processing by catalyzing the addition of a guanosine nucleotide to the 5' end of RNA molecules. This enzymatic process is crucial for the maturation and stability of different RNA species, including mRNA.
RNGTT inhibitors are designed to selectively interfere with the catalytic function of the RNGTT enzyme, leading to alterations in RNA processing and impacting various cellular pathways. The chemical structures of RNGTT inhibitors may vary, allowing for a diverse range of compounds within this class. Researchers are actively investigating the mechanisms by which these inhibitors interact with RNGTT and how their modulation of RNA processing could have implications in cellular biology.
SEE ALSO...
Items 1 to 10 of 11 total
Display:
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Fludarabine | 21679-14-1 | sc-204755 sc-204755A | 5 mg 25 mg | $58.00 $204.00 | 15 | |
Fludarabine is a nucleoside analog that inhibits RNGTT by being incorporated into DNA during replication, leading to chain termination and interference with DNA synthesis. | ||||||
2′-Deoxy-2′,2′-difluorocytidine | 95058-81-4 | sc-275523 sc-275523A | 1 g 5 g | $56.00 $128.00 | ||
Gemcitabine is another nucleoside analog that inhibits RNGTT by disrupting DNA synthesis through its incorporation into growing DNA strands, causing premature chain termination. | ||||||
1-β-D-Arabinofuranosylcytosine | 147-94-4 | sc-201628 sc-201628A sc-201628B sc-201628C sc-201628D | 1 g 5 g 25 g 100 g 250 g | $150.00 $263.00 $518.00 $731.00 $1461.00 | 1 | |
1-β-D-Arabinofuranosylcytosine is a cytidine analog that inhibits RNGTT by being incorporated into DNA, leading to DNA chain termination and inhibition of DNA replication. | ||||||
Idoxuridine | 54-42-2 | sc-205720 sc-205720A | 500 mg 1 g | $104.00 $213.00 | ||
Idoxuridine is a thymidine analog that inhibits RNGTT by being incorporated into DNA, interfering with DNA synthesis and causing chain termination. | ||||||
5-Azacytidine | 320-67-2 | sc-221003 | 500 mg | $280.00 | 4 | |
Azacitidine is a cytidine analog that inhibits RNGTT by getting incorporated into DNA, leading to hypomethylation of DNA and altered gene expression. | ||||||
5-Aza-2′-Deoxycytidine | 2353-33-5 | sc-202424 sc-202424A sc-202424B | 25 mg 100 mg 250 mg | $218.00 $322.00 $426.00 | 7 | |
Decitabine is a cytidine analog that inhibits RNGTT by being incorporated into DNA, causing DNA hypomethylation and impacting gene expression. | ||||||
Fluorouracil | 51-21-8 | sc-29060 sc-29060A | 1 g 5 g | $37.00 $152.00 | 11 | |
5-FU is a pyrimidine analog that inhibits RNGTT by interfering with thymidylate synthase, a key enzyme in DNA synthesis, leading to reduced DNA production. | ||||||
Methotrexate | 59-05-2 | sc-3507 sc-3507A | 100 mg 500 mg | $94.00 $213.00 | 33 | |
Methotrexate inhibits RNGTT by acting as a folate analog and blocking dihydrofolate reductase, an enzyme necessary for DNA synthesis, ultimately disrupting cell proliferation. | ||||||
Etoposide (VP-16) | 33419-42-0 | sc-3512B sc-3512 sc-3512A | 10 mg 100 mg 500 mg | $51.00 $231.00 $523.00 | 63 | |
Etoposide inhibits RNGTT by targeting topoisomerase II, an enzyme involved in DNA replication and repair, causing DNA strand breaks and preventing DNA synthesis. | ||||||
Topotecan | 123948-87-8 | sc-338718 | 100 mg | $582.00 | ||
Topotecan inhibits RNGTT by targeting topoisomerase I, an enzyme responsible for DNA relaxation during replication. Inhibition leads to DNA strand breaks and interference with replication. | ||||||