Molecular structure of Idoxuridine, CAS Number: 54-42-2
Idoxuridine (CAS 54-42-2)
Alternate Names:
5-Iodo-2′-deoxyuridine; 1-(2-Deoxy-β-D-ribofuranosyl)-5-iodouracil; 5-IUdR
Application:
Idoxuridine is a cytotoxic analog of thymidine, antiviral
CAS Number:
54-42-2
Purity:
≥98%
Molecular Weight:
354.10
Molecular Formula:
C9H11IN2O5
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
Idoxuridine inhibits the replication of DNA by incorporating itself into the DNA strand during synthesis. This disrupts the normal base pairing and prevents the accurate replication of the DNA molecule. Idoxuridine is incorporated into viral DNA, leading to the inhibition of viral replication. The incorporation of idoxuridine into viral DNA triggers the immune system to recognize and eliminate the infected cells. Idoxuridine has antitumor activity by inducing DNA damage in cancer cells, leading to cell death.
Idoxuridine (CAS 54-42-2) References
- Idoxuridine in the treatment of herpes zoster. | Simpson, JR. 1975. Practitioner. 215: 226-9. PMID: 1101247
- Synergistic combination effect of cidofovir and idoxuridine on vaccinia virus replication. | Remichkova, M., et al. 2006. Antivir Chem Chemother. 17: 53-8. PMID: 17042327
- Idoxuridine ocular insert therapy. Use in treatment of experimental Herpes simplex keratitis. | Pavan-Langston, D., et al. 1975. Arch Ophthalmol. 93: 1349-51. PMID: 173270
- [Idoxuridine-resistant ocular herpes]. | Colin, J., et al. 1979. Bull Soc Ophtalmol Fr. 79: 889-91. PMID: 233306
- Glycyrrhizin gel as a vehicle for idoxuridine--I. Clinical investigations. | Segal, R. and Pisanty, S. 1987. J Clin Pharm Ther. 12: 165-71. PMID: 3611213
- Does idoxuridine help herpes labialis? | Felser, JM., et al. 1985. N Engl J Med. 312: 859. PMID: 3974668
- Concentrations of idoxuridine in serum, urine, and cerebrospinal fluid of patients with suspected diagnoses of Herpesvirus hominis encephalitis. | Lerner, AM. and Bailey, EJ. 1972. J Clin Invest. 51: 45-9. PMID: 4331799
- Idoxuridine and bacterial corneal infection. | Yamaguchi, K., et al. 1979. Am J Ophthalmol. 87: 202-5. PMID: 434073
- Letter: Idoxuridine in herpes zoster. | Simpson, JR. 1974. Br Med J. 3: 523. PMID: 4414264
- Idoxuridine in herpes simplex virus (type 1) encephalitis. Experience with 29 cases in Michigan, 1966 to 1971. | Nolan, DC., et al. 1973. Ann Intern Med. 78: 243-6. PMID: 4683753
- The development of British pharmacopoeia monographs for idoxuridine and idoxuridine eye drops using high-pressure liquid chromatography for assay and for controlling related impurities. | Carr, GP. 1978. J Chromatogr. 157: 171-84. PMID: 701441
- Idoxuridine-liposome therapy for herpes simplex keratitis. | Smolin, G., et al. 1981. Am J Ophthalmol. 91: 220-5. PMID: 7468738
- Letter: Punctal stenosis-caused by idoxuridine or acrodermatitis enteropathica? | Cherry, PM. and Falcon, MG. 1976. Arch Ophthalmol. 94: 1632. PMID: 962680
Inhibitor of:
Adenovirus-5 hexon, CMV pp52, CMV UL146, HERPUD2, HSV-1 gB, HSV-1 Glycoprotein D, HSV-2 gD, RNGTT, Thymidine Kinase, Varicella Zoster Virus gpI, and VZV IE62.Activator of:
Adenovirus-1 hexon E11, HSV-1 gG, HSV-1 Thymidine Kinase, HSV-1 VP22, HSV-2 gE Envelope Protein, HSV-2 VP22, Rubella Virus structural glycoprotein, Varicella Zoster Virus gpIV, and VZV thymidine kinase.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Idoxuridine, 500 mg | sc-205720 | 500 mg | $104.00 | |||
Idoxuridine, 1 g | sc-205720A | 1 g | $213.00 |