USP29 Activators
USP29, a member of the ubiquitin-specific protease (USP) family, serves as a crucial regulator of cellular processes by modulating protein stability and turnover. Its primary function lies in the deubiquitination of target proteins, a process essential for the removal of ubiquitin tags from substrate proteins marked for degradation by the ubiquitin-proteasome system (UPS). Through its enzymatic activity, USP29 effectively rescues target proteins from degradation, thereby influencing their cellular abundance and activity levels. This role in protein homeostasis is fundamental for maintaining the integrity of various signaling pathways and cellular functions, as aberrant protein turnover can lead to dysregulated cellular processes and contribute to the pathogenesis of various diseases.
Activation of USP29 is intricately linked to the modulation of UPS activity and the stabilization of USP29 protein levels within the cell. Several mechanisms contribute to the activation of USP29, including the inhibition of proteasomal degradation pathways and the modulation of UPS components. Chemical compounds capable of activating USP29 function by interfering with UPS activity, such as inhibiting the proteasome or impeding ubiquitin-dependent degradation pathways. By preventing the degradation of USP29, these compounds facilitate its accumulation and subsequent functional activation, leading to the enhancement of deubiquitinating activity and the modulation of downstream cellular processes. Overall, understanding the regulation and activation of USP29 sheds light on its pivotal role in maintaining protein homeostasis.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Resveratrol | 501-36-0 | sc-200808 sc-200808A sc-200808B | 100 mg 500 mg 5 g | $80.00 $220.00 $460.00 | 64 | |
Resveratrol activates USP29 by inhibiting SIRT1, leading to increased stability and activity of USP29. SIRT1 inhibition prevents USP29 degradation, promoting its activation. | ||||||
Curcumin | 458-37-7 | sc-200509 sc-200509A sc-200509B sc-200509C sc-200509D sc-200509F sc-200509E | 1 g 5 g 25 g 100 g 250 g 1 kg 2.5 kg | $37.00 $69.00 $109.00 $218.00 $239.00 $879.00 $1968.00 | 47 | |
Curcumin activates USP29 by suppressing the ubiquitin-proteasome system (UPS) activity. This inhibition prevents USP29 degradation, allowing for its accumulation and subsequent activation. | ||||||
Quercetin | 117-39-5 | sc-206089 sc-206089A sc-206089E sc-206089C sc-206089D sc-206089B | 100 mg 500 mg 100 g 250 g 1 kg 25 g | $11.00 $17.00 $110.00 $250.00 $936.00 $50.00 | 33 | |
Quercetin activates USP29 by inhibiting the proteasomal degradation pathway. By blocking proteasomal activity, quercetin stabilizes USP29 levels, facilitating its functional activation. | ||||||
(−)Epigallocatechin | 970-74-1 | sc-205673 sc-205673A | 1 mg 5 mg | $65.00 $204.00 | 1 | |
Epigallocatechin activates USP29 by modulating the ubiquitin-proteasome system (UPS). It impedes UPS-mediated degradation of USP29, leading to its stabilization and consequent activation. | ||||||
Genistein | 446-72-0 | sc-3515 sc-3515A sc-3515B sc-3515C sc-3515D sc-3515E sc-3515F | 100 mg 500 mg 1 g 5 g 10 g 25 g 100 g | $45.00 $164.00 $200.00 $402.00 $575.00 $981.00 $2031.00 | 46 | |
Genistein activates USP29 by suppressing proteasomal degradation. Its inhibition of the proteasome prevents USP29 degradation, allowing for its accumulation and subsequent activation. | ||||||
Luteolin | 491-70-3 | sc-203119 sc-203119A sc-203119B sc-203119C sc-203119D | 5 mg 50 mg 500 mg 5 g 500 g | $27.00 $51.00 $101.00 $153.00 $1925.00 | 40 | |
Luteolin activates USP29 by impeding the ubiquitin-proteasome system (UPS). Through UPS inhibition, luteolin promotes USP29 stability and prevents its degradation, facilitating functional activation. | ||||||
Fisetin | 528-48-3 | sc-276440 sc-276440A sc-276440B sc-276440C sc-276440D | 50 mg 100 mg 500 mg 1 g 100 g | $52.00 $79.00 $104.00 $156.00 $2913.00 | 7 | |
Fisetin activates USP29 by inhibiting the ubiquitin-proteasome system (UPS). This inhibition prevents USP29 degradation, leading to its accumulation and subsequent functional activation. | ||||||
Kaempferol | 520-18-3 | sc-202679 sc-202679A sc-202679B | 25 mg 100 mg 1 g | $99.00 $216.00 $510.00 | 11 | |
Kaempferol activates USP29 by modulating the ubiquitin-proteasome system (UPS). By suppressing UPS activity, kaempferol stabilizes USP29 levels, promoting its functional activation. | ||||||
Apigenin | 520-36-5 | sc-3529 sc-3529A sc-3529B sc-3529C sc-3529D sc-3529E sc-3529F | 5 mg 100 mg 1 g 5 g 25 g 100 g 1 kg | $33.00 $214.00 $734.00 $1151.00 $2348.00 $3127.00 $5208.00 | 22 | |
Apigenin activates USP29 by inhibiting the proteasomal degradation pathway. Its suppression of proteasomal activity prevents USP29 degradation, facilitating its accumulation and functional activation. | ||||||
Naringenin | 480-41-1 | sc-219338 | 25 g | $245.00 | 11 | |
Naringenin activates USP29 by modulating the ubiquitin-proteasome system (UPS). Through UPS inhibition, naringenin stabilizes USP29 levels, preventing its degradation and promoting functional activation. | ||||||