USP29 Antibody (1A8): sc-517145
- USP29 Antibody (1A8) is a mouse monoclonal IgG2b κ USP29 antibody provided at 100 µg/ml
- raised against amino acids 131-240 representing partial length USP29 of human origin
- recommended for detection of USP29 of human origin by WB, IP, IF, IHC(P) and ELISA
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for USP29 Antibody (1A8). This work is in progress.
USP29 Antibody (1A8) is a mouse monoclonal IgG2b kappa light chain antibody that detects USP29 protein of human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry with paraffin-embedded sections (IHCP), and enzyme-linked immunosorbent assay (ELISA). Anti-USP29 antibody (1A8) is available as the non-conjugated format. USP29, also known as ubiquitin specific peptidase 29 or HOM-TES-84/86, is a crucial 922 amino acid deubiquitinating enzyme that plays a significant role in the ubiquitin (Ub) pathway, which is essential for regulating various intracellular processes, including signal transduction, transcriptional activation, and cell cycle progression. USP29 functions to remove ubiquitin from target proteins, thereby influencing their stability and activity, which is vital for maintaining cellular homeostasis and responding to stress signals. USP29 belongs to the peptidase C19 family and exhibits catalytic activity that involves the hydrolysis of ubiquitin-thiolester bonds, resulting in the release of free ubiquitin and a thiol. The presence of characteristic motifs such as the cys box and his box in USP29 highlights classification as a type-2 ubiquitin C-terminal hydrolase, further emphasizing importance in the dynamic regulation of protein turnover and signaling pathways.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
USP29 Antibody (1A8) References:
- Deubiquitinating enzymes: their diversity and emerging roles. | Chung, CH. and Baek, SH. 1999. Biochem Biophys Res Commun. 266: 633-40. PMID: 10603300
- Discovery of a novel, paternally expressed ubiquitin-specific processing protease gene through comparative analysis of an imprinted region of mouse chromosome 7 and human chromosome 19q13.4. | Kim, J., et al. 2000. Genome Res. 10: 1138-47. PMID: 10958632
- Imprinting and evolution of two Kruppel-type zinc-finger genes, ZIM3 and ZNF264, located in the PEG3/USP29 imprinted domain. | Kim, J., et al. 2001. Genomics. 77: 91-8. PMID: 11543637
- Genomic organization and imprinting of the Peg3 domain in bovine. | Kim, J., et al. 2007. Genomics. 90: 85-92. PMID: 17509818
- Two evolutionarily conserved sequence elements for Peg3/Usp29 transcription. | Kim, JD., et al. 2008. BMC Mol Biol. 9: 108. PMID: 19068137
- Deubiquitinating enzymes: a new class of biological regulators. | D'Andrea, A. and Pellman, D. 1998. Crit Rev Biochem Mol Biol. 33: 337-52. PMID: 9827704
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
USP29 Antibody (1A8) | sc-517145 | 100 µg/ml | $322.00 |