ZnT-8 Activators
The chemical class ZnT-8 Activators represents a diverse array of compounds that indirectly influence the activity of ZnT-8 through various cellular pathways. This class includes molecules that modulate insulin signaling, cellular metabolism, and stress responses, all of which are key in the regulation of ZnT-8 activity. For example, Forskolin and Metformin act on cAMP levels and AMPK activity, respectively, which can have downstream effects on ZnT-8 function by altering the cellular context, especially in terms of insulin secretion and sensitivity.
Other compounds, such as Genistein and Quercetin, affect insulin signaling through their actions on the tyrosine kinase and PI3K/Akt pathways. Their impact on these pathways can lead to changes in the cellular environment that indirectly influence ZnT-8 activity. Furthermore, molecules like Resveratrol and Curcumin, known for their roles in activating sirtuins and modulating the NF-kB pathway, demonstrate the varied mechanisms through which the compounds in this class can influence ZnT-8.
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Items 1 to 10 of 11 total
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $76.00 $150.00 $725.00 $1385.00 $2050.00 | 73 | |
Adenylyl cyclase activator increasing cAMP levels, which can enhance PKA activity. PKA potentially modulates ZnT-8 through phosphorylation, influencing its transporter activity. | ||||||
Genistein | 446-72-0 | sc-3515 sc-3515A sc-3515B sc-3515C sc-3515D sc-3515E sc-3515F | 100 mg 500 mg 1 g 5 g 10 g 25 g 100 g | $26.00 $92.00 $120.00 $310.00 $500.00 $908.00 $1821.00 | 46 | |
Tyrosine kinase inhibitor. By modulating tyrosine kinase activity, Genistein can affect insulin signaling pathways, indirectly influencing ZnT-8 functionality. | ||||||
Resveratrol | 501-36-0 | sc-200808 sc-200808A sc-200808B | 100 mg 500 mg 5 g | $60.00 $185.00 $365.00 | 64 | |
Sirtuin activator. Influences insulin secretion and sensitivity, potentially modulating ZnT-8 activity in insulin granules. | ||||||
Pioglitazone | 111025-46-8 | sc-202289 sc-202289A | 1 mg 5 mg | $54.00 $123.00 | 13 | |
PPAR-gamma agonist. Modulates insulin sensitivity, potentially affecting ZnT-8 activity indirectly through altered insulin signaling. | ||||||
Quercetin | 117-39-5 | sc-206089 sc-206089A sc-206089E sc-206089C sc-206089D sc-206089B | 100 mg 500 mg 100 g 250 g 1 kg 25 g | $11.00 $17.00 $108.00 $245.00 $918.00 $49.00 | 33 | |
P13K/Akt pathway modulator. By influencing this pathway, Quercetin can indirectly affect ZnT-8 activity linked to insulin signaling. | ||||||
Curcumin | 458-37-7 | sc-200509 sc-200509A sc-200509B sc-200509C sc-200509D sc-200509F sc-200509E | 1 g 5 g 25 g 100 g 250 g 1 kg 2.5 kg | $36.00 $68.00 $107.00 $214.00 $234.00 $862.00 $1968.00 | 47 | |
NF-kB pathway modulator. Influences inflammatory responses and insulin signaling, potentially affecting ZnT-8 activity. | ||||||
(−)-Epigallocatechin Gallate | 989-51-5 | sc-200802 sc-200802A sc-200802B sc-200802C sc-200802D sc-200802E | 10 mg 50 mg 100 mg 500 mg 1 g 10 g | $42.00 $72.00 $124.00 $238.00 $520.00 $1234.00 | 11 | |
Modulator of glucose metabolism. Influences insulin signaling and sensitivity, potentially affecting ZnT-8 activity. | ||||||
Berberine | 2086-83-1 | sc-507337 | 250 mg | $90.00 | 1 | |
AMPK activator. Alters lipid and glucose metabolism, potentially influencing ZnT-8 activity in insulin granules. | ||||||
D,L-Sulforaphane | 4478-93-7 | sc-207495A sc-207495B sc-207495C sc-207495 sc-207495E sc-207495D | 5 mg 10 mg 25 mg 1 g 10 g 250 mg | $150.00 $286.00 $479.00 $1299.00 $8299.00 $915.00 | 22 | |
NRF2 activator. Influences cellular oxidative stress response, potentially impacting ZnT-8 activity. | ||||||
β-Nicotinamide mononucleotide | 1094-61-7 | sc-212376 sc-212376A sc-212376B sc-212376C sc-212376D | 25 mg 100 mg 1 g 2 g 5 g | $92.00 $269.00 $337.00 $510.00 $969.00 | 4 | |
NAD+ precursor. Influences cellular metabolism and insulin signaling, potentially impacting ZnT-8. | ||||||