ZNRD1 Inhibitors
Chemical inhibitors of ZNRD1 function through various mechanisms to modulate its activity within cellular pathways. Staurosporine, a kinase inhibitor, can disrupt the phosphorylation processes essential for ZNRD1's activation, thus hindering its function. Similarly, LY294002 and Wortmannin, both PI3K inhibitors, can suppress the PI3K/AKT signaling pathway, which is integral to ZNRD1's role in cellular processes. By inhibiting this pathway, these chemicals can directly decrease ZNRD1 activity. Another inhibitor, Rapamycin, targets the mTOR pathway, a regulatory pathway for cell growth and proliferation where ZNRD1 is implicated. Inhibition of mTOR signaling by Rapamycin can lead to a reduction in ZNRD1 function. SB203580's inhibition of p38 MAP kinase and U0126's prevention of MEK/ERK pathway activation represent additional routes through which ZNRD1 activity can be controlled, as both p38 MAPK and MEK/ERK are pathways potentially linked to ZNRD1's regulatory functions.
Further, SP600125, by inhibiting JNK, can interfere with the activation of transcription factors or other regulatory proteins that modulate ZNRD1's function. PP2, an Src family kinase inhibitor, can inhibit kinases that are responsible for the phosphorylation of ZNRD1, leading to a reduction in its activity. KN-93's inhibition of CaMKII, if involved in ZNRD1's phosphorylation, would similarly result in diminished ZNRD1 function. PD173074, by inhibiting the FGFR signaling pathways, can disrupt processes associated with ZNRD1, leading to its functional inhibition. Lastly, Bisindolylmaleimide I, as a selective protein kinase C inhibitor, can prevent the activation of ZNRD1 if protein kinase C is involved in its regulation.
SEE ALSO...
Items 1 to 10 of 12 total
Display:
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Staurosporine | 62996-74-1 | sc-3510 sc-3510A sc-3510B | 100 µg 1 mg 5 mg | $82.00 $153.00 $396.00 | 113 | |
As a kinase inhibitor, Staurosporine can inhibit the phosphorylation of ZNRD1 by affecting the kinases that are responsible for its activation, leading to a decrease in ZNRD1 activity. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $123.00 $400.00 | 148 | |
LY294002 is a PI3K inhibitor which would inhibit the PI3K/AKT pathway, a pathway where ZNRD1 is involved in the downstream signaling. This inhibition can result in the reduction of ZNRD1 activity since PI3K/AKT is important for various cellular processes, including those associated with ZNRD1. | ||||||
Rapamycin | 53123-88-9 | sc-3504 sc-3504A sc-3504B | 1 mg 5 mg 25 mg | $63.00 $158.00 $326.00 | 233 | |
Rapamycin is an mTOR inhibitor, which can inhibit the mTOR signaling pathway that regulates cell growth and proliferation, processes in which ZNRD1 is involved. Inhibition of this pathway can lead to the functional inhibition of ZNRD1. | ||||||
SB 203580 | 152121-47-6 | sc-3533 sc-3533A | 1 mg 5 mg | $90.00 $349.00 | 284 | |
SB203580, by inhibiting p38 MAP kinase, can decrease the activity of ZNRD1 by impacting the p38 MAPK pathway, which may play a role in the functional regulation of ZNRD1. | ||||||
SP600125 | 129-56-6 | sc-200635 sc-200635A | 10 mg 50 mg | $40.00 $150.00 | 257 | |
SP600125 inhibits JNK, which could be involved in the activation of transcription factors or other regulatory proteins that control the function of ZNRD1, resulting in its inhibition. | ||||||
U-0126 | 109511-58-2 | sc-222395 sc-222395A | 1 mg 5 mg | $64.00 $246.00 | 136 | |
U0126 is a MEK inhibitor, which can prevent the activation of the MEK/ERK pathway, a pathway that ZNRD1 is known to be associated with. Inhibition of this pathway can thus inhibit the function of ZNRD1. | ||||||
PP 2 | 172889-27-9 | sc-202769 sc-202769A | 1 mg 5 mg | $94.00 $227.00 | 30 | |
PP2 is an Src family kinase inhibitor that can inhibit kinases responsible for the phosphorylation of ZNRD1, thus inhibiting its function. | ||||||
Wortmannin | 19545-26-7 | sc-3505 sc-3505A sc-3505B | 1 mg 5 mg 20 mg | $67.00 $223.00 $425.00 | 97 | |
Wortmannin, as a PI3K inhibitor like LY294002, can suppress the PI3K/AKT signaling pathway reducing the activity of ZNRD1 since this pathway can influence the processes that ZNRD1 is involved in. | ||||||
KN-93 | 139298-40-1 | sc-202199 | 1 mg | $182.00 | 25 | |
KN-93 is a CaMKII inhibitor, which could inhibit the phosphorylation of ZNRD1 if CaMKII is involved in the phosphorylation process of ZNRD1, leading to its functional inhibition. | ||||||
PD173074 | 219580-11-7 | sc-202610 sc-202610A sc-202610B | 1 mg 5 mg 50 mg | $47.00 $143.00 $680.00 | 16 | |
PD173074 is an FGFR inhibitor, which can disrupt the FGFR signaling pathways that are associated with ZNRD1 function, leading to the inhibition of ZNRD1. | ||||||