ZNRD1 Activators
ZNRD1 Activators consist of a diverse array of chemical compounds that facilitate the indirect enhancement of ZNRD1's functional activity via distinct signaling pathways. Forskolin, through its upregulation of cAMP, activates PKA, which then phosphorylates transcription factors that increase the activity of ZNRD1 in gene transcription regulation. Similar to Forskolin, 8-Bromo-cAMP, another cAMP analog, activates PKA, further amplifying ZNRD1's role in cell cycle progression. PMA engages PKC, leading to the modulation of transcription factors that may enhance ZNRD1's DNA repair functions, while Ionomycin, by raising intracellular calcium levels, can activate calcium-dependent kinases that may increase ZNRD1's activity related to cellular stress responses. Sphingosine-1-phosphate activates its receptors to initiate signaling cascades potentially enhancing ZNRD1 activity in cell growth and survival, while Genistein's inhibition of tyrosine kinases can indirectly promote ZNRD1's role in cell proliferation by reducing competitive signaling.
Epigallocatechin gallate (EGCG) inhibits multiple protein kinases, potentially leading to the activation of compensatory pathways that involve ZNRD1's antioxidant response. Finally, Thapsigargin, by inhibiting the SERCA pump, raises intracellular calcium levels, which could activate ZNRD1 through calcium-dependent signaling pathways critical to the cellular stress response. Collectively, these ZNRD1 Activators demonstrate the chemical enhancement of ZNRD1 via targeted effects on various cellular signaling pathways, leading to a greater activity of ZNRD1 without directly upregulating its expression.
SEE ALSO...
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $76.00 $150.00 $725.00 $1385.00 $2050.00 | 73 | |
Forskolin is an adenylate cyclase activator that increases levels of cyclic AMP (cAMP) in cells. Elevated cAMP activates protein kinase A (PKA), which can phosphorylate transcription factors that enhance the expression and functional activity of ZNRD1. | ||||||
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $40.00 $129.00 $210.00 $490.00 $929.00 | 119 | |
PMA is a diacylglycerol analog that activates protein kinase C (PKC). Activated PKC can modulate the function of transcription factors, leading to the increased activity of ZNRD1 by promoting its role in DNA repair and replication. | ||||||
Ionomycin | 56092-82-1 | sc-3592 sc-3592A | 1 mg 5 mg | $76.00 $265.00 | 80 | |
Ionomycin is a calcium ionophore that increases intracellular calcium levels, which can activate calcium/calmodulin-dependent protein kinases. These kinases can then enhance the activity of ZNRD1 by facilitating its role in cellular stress response pathways. | ||||||
D-erythro-Sphingosine-1-phosphate | 26993-30-6 | sc-201383 sc-201383D sc-201383A sc-201383B sc-201383C | 1 mg 2 mg 5 mg 10 mg 25 mg | $162.00 $316.00 $559.00 $889.00 $1693.00 | 7 | |
Sphingosine-1-phosphate is a bioactive lipid that activates sphingosine-1-phosphate receptors, triggering signaling cascades that can lead to the functional activation of ZNRD1 through its involvement in cell growth and survival pathways. | ||||||
8-Bromo-cAMP | 76939-46-3 | sc-201564 sc-201564A | 10 mg 50 mg | $97.00 $224.00 | 30 | |
8-Bromo-cAMP is a cell-permeable cAMP analog that activates PKA. PKA activation can lead to enhanced ZNRD1 activity by promoting its role in the regulation of gene transcription necessary for cell cycle progression. | ||||||
(−)-Epigallocatechin Gallate | 989-51-5 | sc-200802 sc-200802A sc-200802B sc-200802C sc-200802D sc-200802E | 10 mg 50 mg 100 mg 500 mg 1 g 10 g | $42.00 $72.00 $124.00 $238.00 $520.00 $1234.00 | 11 | |
EGCG is a polyphenol that inhibits several protein kinases, potentially leading to the activation of alternative pathways that include ZNRD1's role in the cellular antioxidant response. | ||||||
Thapsigargin | 67526-95-8 | sc-24017 sc-24017A | 1 mg 5 mg | $94.00 $349.00 | 114 | |
Thapsigargin is a SERCA pump inhibitor that raises intracellular calcium levels, which may activate calcium-dependent signaling pathways that enhance the activity of ZNRD1 in the stress response. | ||||||
Genistein | 446-72-0 | sc-3515 sc-3515A sc-3515B sc-3515C sc-3515D sc-3515E sc-3515F | 100 mg 500 mg 1 g 5 g 10 g 25 g 100 g | $26.00 $92.00 $120.00 $310.00 $500.00 $908.00 $1821.00 | 46 | |
Genistein is a tyrosine kinase inhibitor that can increase the functional activity of ZNRD1 by reducing competitive tyrosine kinase signaling, thereby promoting ZNRD1's involvement in cell growth and division processes. | ||||||