ZNF708 Inhibitors
Chemical inhibitors of ZNF708 include a range of compounds that exert their inhibitory effects by interacting with the protein's zinc finger domains, which are vital for its DNA-binding capability and regulatory functions. Disulfiram, clotrimazole, ebselen, pyrithione zinc, 1,10-phenanthroline, clioquinol, PDTC, and tiludronate all function by either chelating zinc ions or binding directly to ZNF708's zinc finger motifs. This binding or chelation leads to a conformational disruption of the zinc finger structure, directly impeding ZNF708's ability to interact with DNA. Such an impairment results in the inhibition of ZNF708's transcriptional regulation activity. For instance, disulfiram and clotrimazole can bind to the zinc finger motifs, preventing ZNF708 from engaging with its DNA targets. In a similar vein, ebselen modifies cysteine residues, which likely alters ZNF708's conformation and hinders its DNA-binding functionality.
Moreover, the inhibition of specific cellular pathways also plays a role in suppressing ZNF708 activity. Chemicals such as TPCA-1 and triptolide inhibit the NF-κB pathway, which is integral to ZNF708's role in gene expression regulation. By suppressing NF-κB activation, these compounds directly hinder ZNF708's ability to modulate gene expression. Additionally, NSC 95397 inhibits Cdc25 phosphatase, leading to changes in the phosphorylation state that ZNF708 requires for its activity. This alteration in phosphorylation can result in the functional inhibition of ZNF708. Lastly, MG-132 targets proteasome activity, leading to the accumulation of proteins within the cell that can disrupt the signaling pathways where ZNF708 operates.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Disulfiram | 97-77-8 | sc-205654 sc-205654A | 50 g 100 g | $53.00 $89.00 | 7 | |
Disulfiram can inhibit ZNF708 by binding to its zinc finger motifs, which are crucial for DNA binding and transcriptional regulation. This binding directly impairs ZNF708's ability to interact with DNA, leading to functional inhibition. | ||||||
Clotrimazole | 23593-75-1 | sc-3583 sc-3583A | 100 mg 1 g | $42.00 $57.00 | 6 | |
Clotrimazole interacts with the zinc finger domains of ZNF708, preventing the protein from binding to DNA and performing its regulatory functions, resulting in direct inhibition of its activity. | ||||||
Ebselen | 60940-34-3 | sc-200740B sc-200740 sc-200740A | 1 mg 25 mg 100 mg | $33.00 $136.00 $458.00 | 5 | |
Ebselen can inhibit ZNF708 by modifying cysteine residues, potentially altering the protein's conformation and impeding its DNA-binding capabilities, thus directly inhibiting its function. | ||||||
Zinc | 7440-66-6 | sc-213177 | 100 g | $48.00 | ||
Pyrithione Zinc disrupts zinc homeostasis, a necessary condition for the structural integrity of ZNF708's zinc finger domains. This disruption leads to a loss of DNA binding capacity and direct inhibition of ZNF708's function. | ||||||
1,10-Phenanthroline | 66-71-7 | sc-255888 sc-255888A | 2.5 g 5 g | $23.00 $32.00 | ||
1,10-Phenanthroline acts as a chelating agent, sequestering zinc ions crucial for ZNF708's zinc finger domain structure and function. This chelation leads to a failure in DNA binding and direct functional inhibition of ZNF708. | ||||||
Clioquinol | 130-26-7 | sc-201066 sc-201066A | 1 g 5 g | $45.00 $115.00 | 2 | |
Clioquinol chelates zinc ions, which are essential for ZNF708's zinc finger domains, directly impairing the protein's ability to bind DNA and thereby inhibiting its function. | ||||||
Pyrrolidinedithiocarbamic acid ammonium salt | 5108-96-3 | sc-203224 sc-203224A | 5 g 25 g | $33.00 $64.00 | 11 | |
PDTC binds zinc ions, potentially altering the zinc finger domains of ZNF708, which are fundamental for its DNA-binding function, resulting in direct inhibition of the protein. | ||||||
IKK-2 Inhibitor IV | 507475-17-4 | sc-203083 | 500 µg | $133.00 | 12 | |
TPCA-1 inhibits NF-κB activation, a pathway essential for ZNF708's role in regulating gene expression. This inhibition can suppress ZNF708 activity by altering transcriptional regulation. | ||||||
Triptolide | 38748-32-2 | sc-200122 sc-200122A | 1 mg 5 mg | $90.00 $204.00 | 13 | |
Triptolide suppresses NF-κB activation, which is crucial for ZNF708's regulatory functions. This suppression leads to a direct inhibition of ZNF708's activity by altering its ability to regulate gene expression. | ||||||
NSC 95397 | 93718-83-3 | sc-203654 sc-203654A | 10 mg 50 mg | $255.00 $847.00 | 9 | |
NSC 95397 inhibits Cdc25 phosphatase, which affects phosphorylation status. Given that ZNF708's activity is assumed to be reliant on phosphorylation, inhibition of Cdc25 phosphatase can lead to functional inhibition of ZNF708 by altering its phosphorylation state. | ||||||