ZNF670 Inhibitors
ZNF670 inhibitors encompass a specialized group of chemical compounds that attenuate the functional activity of ZNF670 by targeting various cellular and molecular pathways. Trichostatin A and 5-Azacytidine disrupt ZNF670's DNA interaction by modifying chromatin accessibility and DNA methylation patterns, respectively. Chloroquine and Mitoxantrone intervene by intercalating into DNA, thus potentially inhibiting ZNF670's DNA-binding function. Proteasome inhibitors like MG-132 and Bortezomib lead to an accumulation of proteins within the cell, which could indirectly affect ZNF670's stability and function by overwhelming the protein degradation systems that normally regulate its levels. Additionally, Alsterpaullone and PD 98059 disrupt ZNF670 function by inhibiting cyclin-dependent kinases and the MAPK/ERK signaling pathway, respectively, which could alter ZNF670's activity through changes in cell cycle progression and phosphorylation status.
The functional activity of ZNF670 is further influenced by the modulation of other key signaling pathways. For instance, LY 294002, by inhibiting PI3K, may reduce AKT-mediated signaling and thus decrease the phosphorylation and activity of ZNF670. Rapamycin's inhibition of mTOR could lead to a reduction in the translation of proteins, including those that interact with or regulate ZNF670. Curcumin's broad effect on signaling pathways, including NF-κB, may also result in decreased ZNF670 activity. Lastly, SB 431542, through selective inhibition of TGF-beta receptor type I, could affect the transcriptional activity of downstream DNA-binding proteins, potentially diminishing the functional activity of ZNF670. Collectively, these inhibitors act through distinct but converging pathways to inhibit the functional activity of ZNF670 without altering its transcription or translation.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Trichostatin A | 58880-19-6 | sc-3511 sc-3511A sc-3511B sc-3511C sc-3511D | 1 mg 5 mg 10 mg 25 mg 50 mg | $149.00 $470.00 $620.00 $1199.00 $2090.00 | 33 | |
Trichostatin A is a histone deacetylase inhibitor which alters chromatin structure and function, leading to an indirect inhibition of DNA-binding proteins such as ZNF670 by affecting the accessibility of the DNA binding sites. | ||||||
5-Azacytidine | 320-67-2 | sc-221003 | 500 mg | $280.00 | 4 | |
5-Azacytidine is a DNA methyltransferase inhibitor, which results in hypomethylation of DNA. Hypomethylated DNA might diminish ZNF670's ability to recognize and bind to its specific DNA methylated targets. | ||||||
Chloroquine | 54-05-7 | sc-507304 | 250 mg | $68.00 | 2 | |
Chloroquine is known to intercalate into DNA, which can disrupt the DNA-binding capacity of zinc finger proteins like ZNF670, thus reducing its functional activity on gene expression. | ||||||
MG-132 [Z-Leu- Leu-Leu-CHO] | 133407-82-6 | sc-201270 sc-201270A sc-201270B | 5 mg 25 mg 100 mg | $56.00 $260.00 $980.00 | 163 | |
MG-132 is a proteasome inhibitor that can lead to the accumulation of misfolded proteins, putting a strain on the protein quality control mechanisms and potentially diminishing the functional stability of ZNF670. | ||||||
Alsterpaullone | 237430-03-4 | sc-202453 sc-202453A | 1 mg 5 mg | $67.00 $306.00 | 2 | |
Alsterpaullone is a cyclin-dependent kinase inhibitor that may alter cell cycle progression. This alteration can indirectly affect the function of cell cycle-regulated proteins such as ZNF670 by changing its phosphorylation states. | ||||||
PD 98059 | 167869-21-8 | sc-3532 sc-3532A | 1 mg 5 mg | $39.00 $90.00 | 212 | |
PD 98059 is a MEK inhibitor which interferes with the MAPK/ERK pathway. Since ZNF670 function may be regulated by phosphorylation through this pathway, its inhibition can lead to reduced ZNF670 activity. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $121.00 $392.00 | 148 | |
LY 294002 is a PI3K inhibitor that disrupts AKT signaling. If ZNF670 functional activity is regulated by AKT-mediated signaling, its inhibition could decrease ZNF670 activity due to reduced phosphorylation. | ||||||
Rapamycin | 53123-88-9 | sc-3504 sc-3504A sc-3504B | 1 mg 5 mg 25 mg | $62.00 $155.00 $320.00 | 233 | |
Rapamycin is an mTOR inhibitor which modulates cellular growth and metabolism. By inhibiting mTOR, the translation of certain mRNAs can be diminished, possibly including those encoding proteins like ZNF670. | ||||||
Mitoxantrone | 65271-80-9 | sc-207888 | 100 mg | $279.00 | 8 | |
Mitoxantrone intercalates into DNA and inhibits topoisomerase II, which can alter DNA conformation and potentially reduce the DNA binding affinity of ZNF670, thereby diminishing its activity. | ||||||
Curcumin | 458-37-7 | sc-200509 sc-200509A sc-200509B sc-200509C sc-200509D sc-200509F sc-200509E | 1 g 5 g 25 g 100 g 250 g 1 kg 2.5 kg | $36.00 $68.00 $107.00 $214.00 $234.00 $862.00 $1968.00 | 47 | |
Curcumin can modulate multiple signaling pathways including NF-κB, which might be involved in the regulation of ZNF670 activity. Inhibition of these pathways could indirectly lead to diminished ZNF670 functionality. | ||||||