ZNF556 Activators
ZNF556 can initiate a cascade of intracellular signaling pathways that result in its functional activation. Forskolin, by elevating cAMP levels, indirectly stimulates protein kinase A (PKA). The activated PKA can then phosphorylate transcription factors that enhance the DNA-binding activity of ZNF556. Similarly, dibutyryl-cAMP, a stable cAMP analog, directly activates PKA, leading to the same outcome. PMA, which activates protein kinase C (PKC), and IBMX, which inhibits phosphodiesterases, also increase phosphorylation events that can affect transcription factors or co-regulatory proteins involved with ZNF556 activation. Retinoic acid, through its interaction with nuclear receptors, influences gene expression patterns that can include proteins modulating ZNF556 activity. Meanwhile, hydrocortisone engages glucocorticoid receptors, which could interact with ZNF556 directly or with its associated regulatory elements.
The modulation of intracellular calcium levels by chemicals such as ionomycin and A23187 activates calcium-dependent signaling pathways, which may include calmodulin-dependent kinases, potentially influencing proteins that regulate ZNF556 activation. EGF and IGF-1, through their respective receptors, activate the MAPK and PI3K/Akt pathways, leading to changes in phosphorylation states of proteins associated with ZNF556. Insulin, via the PI3K/Akt signaling pathway, also affects the regulatory network surrounding ZNF556. BAY 11-7082's inhibition of NF-κB activation could alter the transcriptional environment in a way that favors ZNF556 activation by changing the availability or activity of interacting proteins or co-factors. Collectively, these chemicals engage a variety of cellular mechanisms that converge on the activation of ZNF556, leading to its functional role in cellular processes.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $76.00 $150.00 $725.00 $1385.00 $2050.00 | 73 | |
Forskolin activates adenylyl cyclase, leading to an increase in cAMP levels. Elevated cAMP enhances PKA activity, which can phosphorylate transcription factors that may bind to the ZNF556 promoter, leading to its functional activation. | ||||||
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $40.00 $129.00 $210.00 $490.00 $929.00 | 119 | |
Phorbol 12-myristate 13-acetate (PMA) activates protein kinase C (PKC) which can phosphorylate transcription factors or other proteins that interact with ZNF556, potentially increasing its DNA-binding activity and functional activation. | ||||||
Ionomycin | 56092-82-1 | sc-3592 sc-3592A | 1 mg 5 mg | $76.00 $265.00 | 80 | |
Ionomycin is a calcium ionophore that raises intracellular calcium levels, which can activate calcium-dependent signaling pathways. These pathways may include calmodulin-dependent kinase (CaMK), which can modify proteins that regulate ZNF556, leading to its functional activation. | ||||||
Insulin | 11061-68-0 | sc-29062 sc-29062A sc-29062B | 100 mg 1 g 10 g | $153.00 $1224.00 $12239.00 | 82 | |
Insulin activates the PI3K/Akt signaling pathway, which can lead to downstream effects on transcription factors and other regulatory proteins that could enhance the functional activity of ZNF556 by promoting its DNA binding or interaction with other regulatory proteins. | ||||||
Hydrocortisone | 50-23-7 | sc-300810 | 5 g | $100.00 | 6 | |
Hydrocortisone, a glucocorticoid, can activate glucocorticoid receptors which may interact with the regulatory regions of genes and could enhance the functional activity of ZNF556 through protein-protein interactions in the glucocorticoid response elements. | ||||||
IBMX | 28822-58-4 | sc-201188 sc-201188B sc-201188A | 200 mg 500 mg 1 g | $159.00 $315.00 $598.00 | 34 | |
Isobutylmethylxanthine (IBMX) inhibits phosphodiesterases leading to increased cAMP levels, which can potentiate PKA activity. PKA can then phosphorylate proteins that regulate ZNF556, resulting in its functional activation. | ||||||
Retinoic Acid, all trans | 302-79-4 | sc-200898 sc-200898A sc-200898B sc-200898C | 500 mg 5 g 10 g 100 g | $65.00 $319.00 $575.00 $998.00 | 28 | |
Retinoic acid activates retinoic acid receptors (RARs), which can heterodimerize with retinoid X receptors (RXRs) and bind to retinoic acid response elements (RARE) in the DNA. This can influence proteins that regulate ZNF556, leading to its functional activation. | ||||||
Dibutyryl-cAMP | 16980-89-5 | sc-201567 sc-201567A sc-201567B sc-201567C | 20 mg 100 mg 500 mg 10 g | $45.00 $130.00 $480.00 $4450.00 | 74 | |
Dibutyryl-cAMP, a cAMP analog, directly activates PKA. Activated PKA can phosphorylate transcription factors or co-regulators involved in the functional activation of ZNF556. | ||||||
BAY 11-7082 | 19542-67-7 | sc-200615B sc-200615 sc-200615A | 5 mg 10 mg 50 mg | $61.00 $83.00 $349.00 | 155 | |
BAY 11-7082 inhibits NF-κB activation by blocking IκBα phosphorylation. This can alter the transcriptional landscape and may lead to changes in regulatory proteins that directly interact with ZNF556, leading to its functional activation. | ||||||
A23187 | 52665-69-7 | sc-3591 sc-3591B sc-3591A sc-3591C | 1 mg 5 mg 10 mg 25 mg | $54.00 $128.00 $199.00 $311.00 | 23 | |
A23187 is a calcium ionophore that elevates intracellular calcium, which can activate calmodulin-dependent signaling pathways possibly affecting proteins that regulate the activity of ZNF556, leading to its functional activation. | ||||||