ZNF490 Activators
ZNF490 can influence its activity through various cellular signaling pathways. Forskolin, known for its ability to activate adenylate cyclase, elevates intracellular cyclic AMP (cAMP) levels, which can lead to the activation of ZNF490. Isoproterenol functions similarly by increasing cAMP through the activation of adenylyl cyclase via beta-adrenergic receptors. Dibutyryl-cAMP, a cAMP analogue, directly augments cAMP levels inside cells, thereby potentially activating ZNF490 through cAMP-dependent protein kinase (PKA) pathways. IBMX, by inhibiting phosphodiesterases, also raises cAMP levels, which can activate signaling pathways influencing ZNF490. In a parallel manner, Epinephrine engages adrenergic receptors and can raise cAMP levels, which may alter ZNF490 activity. Rolipram, another phosphodiesterase inhibitor, specifically inhibits PDE4, leading to an increase in cAMP, which can also affect ZNF490 function.
cAMP-related mechanisms, the activity of ZNF490 can be modulated by alterations in calcium signaling. Ionomycin and A23187, both calcium ionophores, increase intracellular calcium levels. This rise in calcium can activate calmodulin and calcium-dependent protein kinases, potentially leading to the activation of ZNF490. Phorbol 12-myristate 13-acetate (PMA) activates protein kinase C (PKC) which can lead to the phosphorylation of ZNF490 or its regulatory proteins, thereby enhancing its activity. Conversely, Chelerythrine, a PKC inhibitor, may lead to the activation of ZNF490 through compensatory cellular mechanisms. LY294002, an inhibitor of PI3K, may also influence ZNF490 function by altering downstream signaling pathways. Zaprinast, by inhibiting PDE5, increases cGMP levels, which may indirectly lead to the activation of ZNF490 through cGMP-dependent protein kinases or by modulating cAMP signaling pathways.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $41.00 $132.00 $214.00 $500.00 $948.00 | 119 | |
Phorbol 12-myristate 13-acetate (PMA) activates protein kinase C (PKC), which may phosphorylate ZNF490 or associated regulatory proteins, potentially enhancing ZNF490's DNA binding activity or interaction with other proteins. | ||||||
Ionomycin, free acid | 56092-81-0 | sc-263405 sc-263405A | 1 mg 5 mg | $96.00 $264.00 | 2 | |
Ionomycin is a calcium ionophore that increases intracellular calcium levels. Calcium signaling can activate calmodulin and calcium-dependent protein kinases, which may play a role in the functional activation of ZNF490. | ||||||
A23187 | 52665-69-7 | sc-3591 sc-3591B sc-3591A sc-3591C | 1 mg 5 mg 10 mg 25 mg | $55.00 $131.00 $203.00 $317.00 | 23 | |
A23187 is another calcium ionophore that raises intracellular calcium levels, similarly leading to the activation of calcium-dependent signaling pathways that could influence ZNF490 function. | ||||||
Isoproterenol Hydrochloride | 51-30-9 | sc-202188 sc-202188A | 100 mg 500 mg | $28.00 $38.00 | 5 | |
Isoproterenol is a beta-adrenergic agonist that can increase cAMP levels in cells through the activation of adenylyl cyclase, which might enhance ZNF490 activation via cAMP-dependent pathways. | ||||||
IBMX | 28822-58-4 | sc-201188 sc-201188B sc-201188A | 200 mg 500 mg 1 g | $260.00 $350.00 $500.00 | 34 | |
3-Isobutyl-1-methylxanthine (IBMX) is a nonspecific inhibitor of phosphodiesterases, leading to increased cAMP and cGMP levels, which might activate signaling pathways that can lead to the functional activation of ZNF490. | ||||||
(−)-Epinephrine | 51-43-4 | sc-205674 sc-205674A sc-205674B sc-205674C sc-205674D | 1 g 5 g 10 g 100 g 1 kg | $41.00 $104.00 $201.00 $1774.00 $16500.00 | ||
Epinephrine, by binding to adrenergic receptors, can also increase intracellular cAMP levels, which might affect the activity of ZNF490 through cAMP-responsive elements within the cellular signaling networks. | ||||||
Chelerythrine | 34316-15-9 | sc-507380 | 100 mg | $540.00 | ||
Chelerythrine is a potent inhibitor of PKC. By inhibiting PKC, it might lead to compensatory regulatory mechanisms in the cell that can activate ZNF490 through alternative pathways or feedback loops. | ||||||
Dibutyryl-cAMP | 16980-89-5 | sc-201567 sc-201567A sc-201567B sc-201567C | 20 mg 100 mg 500 mg 10 g | $47.00 $136.00 $492.00 $4552.00 | 74 | |
Dibutyryl-cAMP is a membrane-permeable cAMP analogue that directly elevates intracellular cAMP levels, potentially leading to activation of ZNF490 by cAMP-dependent protein kinase (PKA) signaling pathways. | ||||||
Zaprinast (M&B 22948) | 37762-06-4 | sc-201206 sc-201206A | 25 mg 100 mg | $105.00 $250.00 | 8 | |
Zaprinast inhibits phosphodiesterase 5 (PDE5), leading to increased cGMP levels, which might indirectly lead to the activation of ZNF490 through cGMP-dependent protein kinases or cross-talk with cAMP pathways. | ||||||
Rolipram | 61413-54-5 | sc-3563 sc-3563A | 5 mg 50 mg | $77.00 $216.00 | 18 | |
Rolipram is a selective inhibitor of phosphodiesterase 4 (PDE4), which increases intracellular cAMP by preventing its breakdown, potentially leading to activation of ZNF490 through cAMP-dependent signaling pathways. | ||||||