ZNF37A Activators
ZNF37A activators are a diverse set of chemical compounds that indirectly enhance the functional activity of ZNF37A, a protein influenced by several cellular signaling pathways. Forskolin, through its adenylyl cyclase stimulation, raises cyclic AMP levels, which then activates PKA. The activated PKA can phosphorylate regulatory proteins that may increase the DNA-binding affinity of ZNF37A, thereby enhancing its transcriptional activity. Ionomycin, by increasing intracellular calcium, activates calcineurin, which in turn could dephosphorylate and activate transcription factors that work in concert with ZNF37A, potentially increasing its DNA-binding efficiency. Phorbol 12-myristate 13-acetate (PMA) activates PKC, which might alter phosphorylation of proteins associated with ZNF37A, enhancing its transcriptional modulation capabilities. Notably, 5-Azacytidine inhibits DNA methyltransferases, possibly leading to a less methylated genome, which could facilitate ZNF37A access to DNA and thereby increase its activity.
Furthermore, Trichostatin A, as a histone deacetylase inhibitor, might lead to a relaxed chromatin state, potentially granting ZNF37A greater access to DNA. Retinoic Acid may modulate gene expression through its receptors, which could dimerize with other transcription factors and enhance ZNF37A's DNA interaction. Sulforaphane, by modulating redox-sensitive transcription factors, alongside A23187, another calcium ionophore, may activate signaling pathways that elevate ZNF37A activity. Oligomycin A, through its impact on ATP synthesis and subsequent AMPK activation, might indirectly enhance ZNF37A's transcriptional regulation. Similarly, Epigallocatechin Gallate (EGCG) with its kinase inhibitory properties, Zinc Pyrithione by boosting intracellular zinc levels essential for ZNF37A's structure, and Dibutyryl-cAMP, a cAMP analog that activates PKA, all potentially lead to enhanced ZNF37A activity, emphasizing the multifaceted approach that these activators employ to regulate the transcriptional functions of ZNF37A.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $78.00 $153.00 $740.00 $1413.00 $2091.00 | 73 | |
Forskolin activates adenylyl cyclase, leading to increased levels of cyclic AMP (cAMP), which in turn activates PKA. PKA phosphorylates various proteins that can be involved in DNA binding affinity, potentially enhancing ZNF37A activity. | ||||||
Ionomycin | 56092-82-1 | sc-3592 sc-3592A | 1 mg 5 mg | $78.00 $270.00 | 80 | |
Ionomycin acts as a calcium ionophore, increasing intracellular calcium concentration which can activate calcineurin. Calcineurin dephosphorylates transcription factors that may cooperate with ZNF37A to enhance its DNA binding activity. | ||||||
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $41.00 $132.00 $214.00 $500.00 $948.00 | 119 | |
PMA activates protein kinase C (PKC) which can alter the phosphorylation state of proteins that interact with ZNF37A, potentially enhancing its role in transcriptional regulation. | ||||||
5-Azacytidine | 320-67-2 | sc-221003 | 500 mg | $280.00 | 4 | |
5-Azacytidine is a DNA methyltransferase inhibitor that could lead to the hypomethylation of DNA and histones, potentially affecting the chromatin structure and increasing ZNF37A access to DNA. | ||||||
Trichostatin A | 58880-19-6 | sc-3511 sc-3511A sc-3511B sc-3511C sc-3511D | 1 mg 5 mg 10 mg 25 mg 50 mg | $152.00 $479.00 $632.00 $1223.00 $2132.00 | 33 | |
Trichostatin A is a histone deacetylase inhibitor which can result in a more open chromatin structure, possibly facilitating greater ZNF37A binding to its target DNA sequences. | ||||||
Retinoic Acid, all trans | 302-79-4 | sc-200898 sc-200898A sc-200898B sc-200898C | 500 mg 5 g 10 g 100 g | $66.00 $325.00 $587.00 $1018.00 | 28 | |
Retinoic Acid influences gene expression through retinoic acid receptors, which can heterodimerize with other transcription factors, potentially increasing the activity of ZNF37A by promoting its binding to DNA. | ||||||
D,L-Sulforaphane | 4478-93-7 | sc-207495A sc-207495B sc-207495C sc-207495 sc-207495E sc-207495D | 5 mg 10 mg 25 mg 1 g 10 g 250 mg | $153.00 $292.00 $489.00 $1325.00 $8465.00 $933.00 | 22 | |
Sulforaphane can influence the expression of genes by affecting transcription factor activity via redox-sensitive pathways, which could enhance the activity of ZNF37A in the cellular context. | ||||||
A23187 | 52665-69-7 | sc-3591 sc-3591B sc-3591A sc-3591C | 1 mg 5 mg 10 mg 25 mg | $55.00 $131.00 $203.00 $317.00 | 23 | |
A23187 acts as a calcium ionophore similar to ionomycin, raising intracellular calcium levels, which can trigger signaling pathways that potentially enhance the transcriptional activity of ZNF37A. | ||||||
Oligomycin A | 579-13-5 | sc-201551 sc-201551A sc-201551B sc-201551C sc-201551D | 5 mg 25 mg 100 mg 500 mg 1 g | $179.00 $612.00 $1203.00 $5202.00 $9364.00 | 26 | |
Oligomycin A inhibits ATP synthase, which can lead to changes in cellular energy status and AMPK activation. AMPK can phosphorylate transcriptional regulators and may indirectly enhance the functional activity of ZNF37A. | ||||||
(−)-Epigallocatechin Gallate | 989-51-5 | sc-200802 sc-200802A sc-200802B sc-200802C sc-200802D sc-200802E | 10 mg 50 mg 100 mg 500 mg 1 g 10 g | $43.00 $73.00 $126.00 $243.00 $530.00 $1259.00 | 11 | |
EGCG inhibits various kinases and has been shown to affect transcription factor activity. This may lead to a change in protein interactions and enhance the transcriptional activity of ZNF37A. | ||||||