ZNF266 Activators
ZNF266 function through various signaling pathways and mechanisms to modulate its activity within cells. Forskolin, by directly stimulating adenylyl cyclase, increases intracellular cyclic AMP (cAMP) concentrations, which in turn activate protein kinase A (PKA). Activated PKA can phosphorylate a plethora of proteins, including transcription factors or regulatory proteins that interact with ZNF266, leading to its functional activation. Similarly, Dibutyryl cyclic AMP (dbcAMP), a cAMP analog, bypasses cellular receptors and directly activates PKA, following the same route to ZNF266 activation.
Ionomycin raises intracellular calcium levels, acting as a secondary messenger that activates calcium-dependent kinases, which may phosphorylate ZNF266 or proteins associated with its regulation. Phorbol 12-myristate 13-acetate (PMA) is a diester that activates protein kinase C (PKC), which then can modify numerous substrates, including those involved in ZNF266 signaling pathways. Bryostatin 1, a modulator of PKC, can similarly influence ZNF266 through PKC-dependent pathways. Epidermal Growth Factor (EGF) engages its receptor, triggering the MAPK/ERK cascade that can culminate in the phosphorylation of proteins regulating ZNF266. Insulin binds to its receptor and initiates a cascade that activates the PI3K/Akt pathway, which may target proteins governing ZNF266 activity. Inhibitors of protein phosphatases like Sodium orthovanadate, Okadaic acid, and Calyculin A increase the phosphorylation levels of cellular proteins by preventing dephosphorylation, potentially affecting ZNF266 activation status. Anisomycin, which inhibits protein synthesis but also activates stress-activated kinases such as JNK, can lead to the phosphorylation of transcription factors or regulatory proteins related to ZNF266. Finally, Lithium chloride inhibits GSK-3, possibly resulting in the stabilization of proteins that interact with or regulate ZNF266, promoting its activation.
SEE ALSO...
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Ionomycin | 56092-82-1 | sc-3592 sc-3592A | 1 mg 5 mg | $78.00 $270.00 | 80 | |
Ionomycin is a calcium ionophore that raises intracellular calcium levels. Calcium is a universal secondary messenger that can activate calcium-dependent protein kinases such as calmodulin-dependent kinase (CaMK), which may phosphorylate ZNF266 or associated regulatory proteins, resulting in the functional activation of ZNF266. | ||||||
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $41.00 $132.00 $214.00 $500.00 $948.00 | 119 | |
PMA is a potent activator of protein kinase C (PKC). PKC, upon activation, can phosphorylate various substrates, including proteins that may interact with ZNF266 or are part of signaling pathways involving ZNF266, leading to its functional activation. | ||||||
Insulin | 11061-68-0 | sc-29062 sc-29062A sc-29062B | 100 mg 1 g 10 g | $156.00 $1248.00 $12508.00 | 82 | |
Insulin interacts with its receptor to initiate a signaling cascade that activates the PI3K/Akt pathway. Akt can phosphorylate and activate a wide range of proteins, including those that may be involved in the regulation of ZNF266's activity. | ||||||
Adenosine 3′,5′-cyclic monophosphate | 60-92-4 | sc-217584 sc-217584A sc-217584B sc-217584C sc-217584D sc-217584E | 100 mg 250 mg 5 g 10 g 25 g 50 g | $116.00 $179.00 $265.00 $369.00 $629.00 $1150.00 | ||
dbcAMP is a cell-permeable cAMP analog that activates PKA. PKA can phosphorylate various proteins and transcription factors that could interact with ZNF266, leading to the functional activation of ZNF266. | ||||||
Sodium Orthovanadate | 13721-39-6 | sc-3540 sc-3540B sc-3540A | 5 g 10 g 50 g | $49.00 $57.00 $187.00 | 142 | |
Sodium orthovanadate is an inhibitor of protein tyrosine phosphatases. Inhibition of these phosphatases can lead to increased phosphorylation levels of proteins within the cell. This can affect signaling pathways that involve ZNF266, leading to its phosphorylation and functional activation. | ||||||
Okadaic Acid | 78111-17-8 | sc-3513 sc-3513A sc-3513B | 25 µg 100 µg 1 mg | $291.00 $530.00 $1800.00 | 78 | |
Okadaic acid is a potent inhibitor of protein phosphatases 1 and 2A. By inhibiting these phosphatases, it can cause an increase in the phosphorylation state of cellular proteins, which may include proteins related to the functional activation of ZNF266. | ||||||
Anisomycin | 22862-76-6 | sc-3524 sc-3524A | 5 mg 50 mg | $99.00 $259.00 | 36 | |
Anisomycin is a protein synthesis inhibitor that also activates stress-activated protein kinases such as JNK. Activation of JNK can lead to the phosphorylation of transcription factors or other proteins that might be involved in the activation of ZNF266. | ||||||
Calyculin A | 101932-71-2 | sc-24000 sc-24000A | 10 µg 100 µg | $163.00 $800.00 | 59 | |
Calyculin A is another inhibitor of protein phosphatases, specifically PP1 and PP2A, leading to increased phosphorylation within cellular proteins. Similar to okadaic acid, this can indirectly lead to the activation of proteins associated with ZNF266's functional role. | ||||||
Bryostatin 1 | 83314-01-6 | sc-201407 | 10 µg | $245.00 | 9 | |
Bryostatin 1 is a modulator of protein kinase C (PKC). While it can act as both an activator and an inhibitor, in certain contexts it functionally activates PKC, which in turn could phosphorylate and activate proteins that regulate the activity of ZNF266. | ||||||
Lithium | 7439-93-2 | sc-252954 | 50 g | $214.00 | ||
Lithium chloride inhibits glycogen synthase kinase-3 (GSK-3). Inhibition of GSK-3 can lead to stabilization and activation of β-catenin and other downstream effectors that may regulate or interact with ZNF266, leading to its functional activation. | ||||||