ZNF14 Activators
ZNF14 utilize various biochemical pathways to enhance the DNA binding affinity and functional activation of the protein. Zinc Pyrithione is one such activator that operates by chelating zinc ions, an essential component for the structural maintenance of zinc finger proteins like ZNF14. This chelation process facilitates the protein's ability to bind to DNA with greater affinity. Similarly, Trichostatin A and Sodium Butyrate, both histone deacetylase inhibitors, induce an open chromatin configuration. This relaxed chromatin state increases the accessibility of ZNF14 to its DNA binding sites, enabling a more efficient interaction with the target sequences. The action of 5-Azacytidine complements these effects by inhibiting DNA methyltransferase, thereby reducing methylation levels and further promoting the DNA binding capability of ZNF14.
MG132, a proteasome inhibitor, can cause an accumulation of regulatory proteins that may include cofactors essential for ZNF14's activation, thus amplifying its functional presence. Disulfiram interacts with metal ions, potentially altering the conformation of ZNF14 and enhancing its DNA binding activity. Retinoic Acid modulates the cellular environment in a manner favorable to the activity of DNA-binding proteins such as ZNF14. Chloroquine, by interfering with lysosomal acidification, may stabilize co-activators that assist in the functional activation of ZNF14. Forskolin's contribution involves the elevation of cAMP levels, which in turn activates protein kinase A, potentially leading to the phosphorylation and activation of ZNF14. Resveratrol activates sirtuins which can alter chromatin architecture, favoring ZNF14's interaction with DNA. Thapsigargin raises intracellular calcium levels, which could activate kinases that phosphorylate and activate ZNF14. Finally, Piceatannol, by inhibiting Syk kinase, might initiate a signaling cascade resulting in the activation of transcription factors and co-activators that work alongside ZNF14 to promote its DNA binding and functional activation.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Zinc | 7440-66-6 | sc-213177 | 100 g | $47.00 | ||
Zinc Pyrithione can activate ZNF14 by enhancing the DNA binding affinity of zinc finger proteins through the chelation of zinc ions, which are critical for the structural integrity of these types of proteins. This leads to an increase in ZNF14's ability to interact with its target DNA sequences, thus functionally activating it. | ||||||
Trichostatin A | 58880-19-6 | sc-3511 sc-3511A sc-3511B sc-3511C sc-3511D | 1 mg 5 mg 10 mg 25 mg 50 mg | $149.00 $470.00 $620.00 $1199.00 $2090.00 | 33 | |
Trichostatin A is a histone deacetylase inhibitor that can lead to an open chromatin structure, increasing the accessibility of ZNF14 to its DNA binding sites. This can lead to functional activation of ZNF14 by facilitating its ability to bind DNA and exert its gene regulatory functions. | ||||||
5-Azacytidine | 320-67-2 | sc-221003 | 500 mg | $280.00 | 4 | |
5-Azacytidine, a DNA methyltransferase inhibitor, reduces methylation levels, which can enhance the DNA binding capability of ZNF14, thus leading to its functional activation as it can more effectively engage with its target gene promoters. | ||||||
MG-132 [Z-Leu- Leu-Leu-CHO] | 133407-82-6 | sc-201270 sc-201270A sc-201270B | 5 mg 25 mg 100 mg | $56.00 $260.00 $980.00 | 163 | |
MG132 is a proteasome inhibitor that can lead to the accumulation of regulatory proteins, potentially increasing the concentration of cofactors necessary for ZNF14 activation and therefore enhancing its functional activity. | ||||||
Disulfiram | 97-77-8 | sc-205654 sc-205654A | 50 g 100 g | $52.00 $87.00 | 7 | |
Disulfiram can bind to copper ions forming a complex that may interact with zinc finger domains, like those in ZNF14, potentially leading to conformational changes that activate ZNF14's DNA binding activity. | ||||||
Sodium Butyrate | 156-54-7 | sc-202341 sc-202341B sc-202341A sc-202341C | 250 mg 5 g 25 g 500 g | $30.00 $46.00 $82.00 $218.00 | 19 | |
Sodium Butyrate, a histone deacetylase inhibitor, can increase the acetylation of histones, leading to a less compact chromatin structure and potentially enhancing the ability of ZNF14 to access and activate its DNA targets. | ||||||
Retinoic Acid, all trans | 302-79-4 | sc-200898 sc-200898A sc-200898B sc-200898C | 500 mg 5 g 10 g 100 g | $65.00 $319.00 $575.00 $998.00 | 28 | |
Retinoic Acid can regulate gene expression and may enhance ZNF14 activity by inducing a cellular environment that promotes the functional activity of DNA-binding proteins such as ZNF14. | ||||||
Chloroquine | 54-05-7 | sc-507304 | 250 mg | $68.00 | 2 | |
Chloroquine can interfere with lysosomal acidification, which might stabilize transcription factors and co-activators that enhance ZNF14's functional activation by promoting its binding to DNA. | ||||||
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $76.00 $150.00 $725.00 $1385.00 $2050.00 | 73 | |
Forskolin activates adenylate cyclase, leading to an increase in cAMP, which can enhance protein kinase A (PKA) activity. PKA phosphorylation of transcription factors may enhance ZNF14's functional activation and DNA binding capacity. | ||||||
Resveratrol | 501-36-0 | sc-200808 sc-200808A sc-200808B | 100 mg 500 mg 5 g | $60.00 $185.00 $365.00 | 64 | |
Resveratrol is known to activate sirtuins which can deacetylate histones, leading to a change in chromatin structure that could enhance ZNF14's ability to functionally activate by binding to its DNA targets more effectively. | ||||||