ZDHHC21 Inhibitors
ZDHHC21 Inhibitors belong to a specific chemical class that targets a crucial enzyme in cellular processes known as palmitoyl acyltransferase, specifically the zinc finger DHHC domain-containing 21 enzyme (ZDHHC21). This enzyme is responsible for the addition of palmitate, a lipid molecule, to cysteine residues of substrate proteins, a process known as S-palmitoylation. S-palmitoylation plays a pivotal role in regulating the localization, stability, and function of a myriad of proteins involved in diverse cellular functions, including signal transduction, membrane trafficking, and protein-protein interactions.
ZDHHC21, as a member of the DHHC family, is integral to this palmitoylation mechanism, and its inhibition has been identified as a strategy to modulate cellular processes governed by palmitoylated proteins.ZDHHC21 Inhibitors typically demonstrate selectivity in disrupting the enzymatic activity of ZDHHC21, thereby impeding the palmitoylation of specific target proteins. Researchers and drug developers have focused on elucidating the structural and biochemical aspects of ZDHHC21 Inhibitors to enhance their specificity and efficacy.
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Items 1 to 10 of 11 total
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Tunicamycin | 11089-65-9 | sc-3506A sc-3506 | 5 mg 10 mg | $172.00 $305.00 | 66 | |
It inhibits N-linked glycosylation, a process that often precedes palmitoylation. This could indirectly reduce ZDHHC21 activity. | ||||||
Cerulenin (synthetic) | 17397-89-6 | sc-200827 sc-200827A sc-200827B | 5 mg 10 mg 50 mg | $161.00 $312.00 $1210.00 | 9 | |
Cerulenin inhibits fatty acid synthesis, indirectly influencing palmitoylation and thus ZDHHC21 activity. | ||||||
Curcumin | 458-37-7 | sc-200509 sc-200509A sc-200509B sc-200509C sc-200509D sc-200509F sc-200509E | 1 g 5 g 25 g 100 g 250 g 1 kg 2.5 kg | $37.00 $69.00 $109.00 $218.00 $239.00 $879.00 $1968.00 | 47 | |
Curcumin indirectly affects palmitoylation by modulating fatty acid metabolism. | ||||||
Anacardic Acid | 16611-84-0 | sc-202463 sc-202463A | 5 mg 25 mg | $102.00 $204.00 | 13 | |
It is a non-specific inhibitor of histone acetyltransferases, which can indirectly affect protein palmitoylation and ZDHHC21 function. | ||||||
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $78.00 $153.00 $740.00 $1413.00 $2091.00 | 73 | |
Forskolin increases cellular cAMP levels, which may indirectly modulate ZDHHC21 activity by affecting protein kinase A, a palmitoylated protein. | ||||||
Metformin | 657-24-9 | sc-507370 | 10 mg | $79.00 | 2 | |
Metformin can alter lipid metabolism, which may indirectly inhibit the function of ZDHHC21. | ||||||
Lovastatin | 75330-75-5 | sc-200850 sc-200850A sc-200850B | 5 mg 25 mg 100 mg | $29.00 $90.00 $339.00 | 12 | |
Statins inhibit HMG-CoA reductase, a key enzyme in cholesterol synthesis, and may indirectly affect ZDHHC21 activity by impacting cellular lipid profiles. | ||||||
Fluorouracil | 51-21-8 | sc-29060 sc-29060A | 1 g 5 g | $37.00 $152.00 | 11 | |
As an antimetabolite, 5-Fluorouracil can affect cellular metabolism including lipid metabolism, thus potentially influencing ZDHHC21 indirectly. | ||||||
Lipase Inhibitor, THL | 96829-58-2 | sc-203108 | 50 mg | $52.00 | 7 | |
Orlistat inhibits fatty acid synthase, potentially influencing the function of ZDHHC21 indirectly. | ||||||
TOFA (5-(Tetradecyloxy)-2-furoic acid) | 54857-86-2 | sc-200653 sc-200653A | 10 mg 50 mg | $97.00 $374.00 | 15 | |
TOFA inhibits acetyl-CoA carboxylase, a key enzyme in fatty acid biosynthesis, which may indirectly affect ZDHHC21 function. | ||||||