ZBTB3 Activators
ZBTB3 can influence its activity through various intracellular signaling pathways that modulate protein phosphorylation states. Forskolin, by directly stimulating adenylate cyclase, raises cAMP levels in the cell, which in turn activates protein kinase A (PKA). This activation can lead to the phosphorylation of proteins within the cell, altering their function and interactions. In the context of ZBTB3, if it is a substrate for PKA or its activity is regulated by PKA-mediated phosphorylation, Forskolin's action would result in the activation of ZBTB3. Similarly, Dibutyryl-cAMP, a cell-permeable analog of cAMP, also activates PKA, potentially leading to the phosphorylation and subsequent activation of ZBTB3. Compounds like IBMX, which inhibits phosphodiesterases, can indirectly promote PKA activation by preventing the breakdown of cAMP, thus sustaining its activity and potentially influencing ZBTB3 activation.
Other compounds activate ZBTB3 through different mechanisms involving calcium signaling. Ionomycin and A23187, both calcium ionophores, raise intracellular calcium levels, which may activate various calcium-dependent proteins capable of modifying ZBTB3 activity. FPL 64176 and Thapsigargin also increase intracellular calcium concentrations, FPL 64176 by activating calcium channels and Thapsigargin by inhibiting the sarco/endoplasmic reticulum Ca2+-ATPase (SERCA). Elevated calcium triggers downstream signaling cascades that can lead to the phosphorylation or other post-translational modifications of ZBTB3. Phorbol esters like PMA and TPA activate protein kinase C (PKC), which can phosphorylate substrates that regulate ZBTB3 activity. Additionally, Okadaic Acid, by inhibiting protein phosphatases PP1 and PP2A, can increase the phosphorylation levels of proteins within the cell, which might include ZBTB3 or its regulatory proteins, thereby modulating its activity. Conversely, BIM, a PKC inhibitor, can also activate PKC at certain concentrations, and such dual activity could have implications for ZBTB3 activation through phosphorylation events.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $76.00 $150.00 $725.00 $1385.00 $2050.00 | 73 | |
Forskolin directly stimulates adenylate cyclase, leading to an increase in cAMP levels, which can activate PKA. PKA is known to phosphorylate various proteins, and through this mechanism, Forskolin could lead to the activation of ZBTB3 assuming ZBTB3 is a substrate for PKA or is regulated by PKA-mediated phosphorylation events. | ||||||
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $40.00 $129.00 $210.00 $490.00 $929.00 | 119 | |
Phorbol 12-myristate 13-acetate (PMA) activates protein kinase C (PKC), which is involved in various signaling pathways. PKC activation can lead to phosphorylation and activation of proteins that may interact with or regulate ZBTB3 activity in cellular contexts where PKC signaling influences ZBTB3 function. | ||||||
Ionomycin | 56092-82-1 | sc-3592 sc-3592A | 1 mg 5 mg | $76.00 $265.00 | 80 | |
Ionomycin acts as a calcium ionophore, raising intracellular calcium levels, which can activate calcium-dependent signaling pathways. Elevated calcium may activate calmodulin-dependent kinases or calcineurin, potentially leading to the phosphorylation or dephosphorylation of ZBTB3 or its cofactors, thereby promoting ZBTB3 activation. | ||||||
A23187 | 52665-69-7 | sc-3591 sc-3591B sc-3591A sc-3591C | 1 mg 5 mg 10 mg 25 mg | $54.00 $128.00 $199.00 $311.00 | 23 | |
A23187 is another calcium ionophore that increases intracellular calcium levels, similarly to Ionomycin, and thus can also activate calcium-dependent proteins that might influence ZBTB3 activation through phosphorylation or conformational changes that affect its activity. | ||||||
Azelnidipine | 123524-52-7 | sc-252395 | 10 mg | $86.00 | ||
FPL 64176 is a calcium channel activator which increases calcium influx into cells, potentially activating calcium-dependent kinases or phosphatases that could influence the activation state of ZBTB3 by modifying its phosphorylation status or that of associated regulatory proteins. | ||||||
Thapsigargin | 67526-95-8 | sc-24017 sc-24017A | 1 mg 5 mg | $94.00 $349.00 | 114 | |
Thapsigargin inhibits the sarco/endoplasmic reticulum Ca2+-ATPase (SERCA) and causes an increase in cytosolic calcium levels. This elevation in calcium could activate downstream targets affecting ZBTB3 activation through post-translational modifications. | ||||||
IBMX | 28822-58-4 | sc-201188 sc-201188B sc-201188A | 200 mg 500 mg 1 g | $159.00 $315.00 $598.00 | 34 | |
3-Isobutyl-1-methylxanthine (IBMX) is a non-specific inhibitor of phosphodiesterases, leading to elevated cAMP and cGMP levels, which can activate PKA or PKG. Activation of these kinases could trigger phosphorylation cascades that might result in the activation of ZBTB3. | ||||||
Anisomycin | 22862-76-6 | sc-3524 sc-3524A | 5 mg 50 mg | $97.00 $254.00 | 36 | |
Anisomycin is a protein synthesis inhibitor that can also activate stress-activated protein kinases such as JNK and p38 MAP kinase. The activation of these kinases may lead to the activation of transcription factors or other proteins that could interact with ZBTB3 to modulate its activity. | ||||||
Okadaic Acid | 78111-17-8 | sc-3513 sc-3513A sc-3513B | 25 µg 100 µg 1 mg | $285.00 $520.00 $1300.00 | 78 | |
Okadaic Acid is a potent inhibitor of protein phosphatases PP1 and PP2A. Inhibition of these phosphatases can lead to increased phosphorylation of various proteins, potentially including ZBTB3 or proteins that regulate ZBTB3 activity. | ||||||
Dibutyryl-cAMP | 16980-89-5 | sc-201567 sc-201567A sc-201567B sc-201567C | 20 mg 100 mg 500 mg 10 g | $45.00 $130.00 $480.00 $4450.00 | 74 | |
Dibutyryl-cAMP is a cell-permeable cAMP analog that activates PKA. The activation of PKA can lead to the phosphorylation of a range of proteins, potentially including ZBTB3, thereby enhancing its activity through post-translational modification. | ||||||