XKR4, or XK-related protein 4, is a lesser-known entity within the XK protein family, which is characterized by a conserved sequence motif known as the XK domain. The XKR4 gene, responsible for encoding the XKR4 protein, is mapped to human chromosome 8, like other members of its family.XKR4 is a transmembrane protein, meaning it spans across the cellular membrane with both intracellular and extracellular regions. This structural characteristic allows it to potentially partake in an array of cellular processes, such as facilitating molecular transport, mediating signal transduction, and contributing to cell-cell interactions. The transmembrane nature of XKR4 is essential for its positioning and functionality within the cellular environment.
The expression patterns of XKR4 may vary among different tissue types and developmental stages, implying a multifaceted role in physiological processes. This could include involvement in apoptotic pathways, cellular communication, or the regulation of membrane integrity and ion balance within cells.Research into the protein-protein interactions and signaling cascades associated with XKR4 is critical for a deeper understanding of its biological functions. If XKR4 is found to interact with proteins that are integral to cellular junctions or signaling, it could suggest a role in maintaining tissue cohesion or transmitting cellular signals.Alterations in the expression or structure of the XKR4 gene can potentially be linked to certain diseases, making XKR4 a protein of interest for medical research. As scientific investigation into XKR4 advances, the elucidation of its actions and relevance to health and disease may offer new insights into cell biology.
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $76.00 $150.00 $725.00 $1385.00 $2050.00 | 73 | |
Forskolin is known to activate adenylate cyclase, leading to increased cAMP levels, which can modulate various signaling pathways, potentially influencing XKR4 activity. | ||||||
IBMX | 28822-58-4 | sc-201188 sc-201188B sc-201188A | 200 mg 500 mg 1 g | $159.00 $315.00 $598.00 | 34 | |
IBMX acts as a non-selective inhibitor of phosphodiesterases, elevating cAMP and cGMP levels in cells, which may indirectly affect XKR4. | ||||||
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $40.00 $129.00 $210.00 $490.00 $929.00 | 119 | |
PMA is a potent activator of protein kinase C (PKC), and PKC activation can lead to varied cellular responses that might impact XKR4 activity. | ||||||
Ionomycin | 56092-82-1 | sc-3592 sc-3592A | 1 mg 5 mg | $76.00 $265.00 | 80 | |
Ionomycin is a calcium ionophore that increases intracellular calcium levels, potentially influencing pathways that could affect XKR4. | ||||||
A23187 | 52665-69-7 | sc-3591 sc-3591B sc-3591A sc-3591C | 1 mg 5 mg 10 mg 25 mg | $54.00 $128.00 $199.00 $311.00 | 23 | |
Similar to Ionomycin, A23187 is a calcium ionophore and could indirectly influence XKR4 activity by altering calcium-dependent signaling pathways. | ||||||
Insulin | 11061-68-0 | sc-29062 sc-29062A sc-29062B | 100 mg 1 g 10 g | $153.00 $1224.00 $12239.00 | 82 | |
Insulin activates various signaling pathways, including PI3K/Akt, which might have an indirect effect on XKR4. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $121.00 $392.00 | 148 | |
LY294002 is a PI3K inhibitor, but its use could indirectly affect XKR4 activity through modulating downstream signaling pathways. | ||||||
PD 98059 | 167869-21-8 | sc-3532 sc-3532A | 1 mg 5 mg | $39.00 $90.00 | 212 | |
PD98059 is an inhibitor of MEK, which is involved in the MAPK/ERK pathway, potentially influencing XKR4 activity indirectly. | ||||||
SB 203580 | 152121-47-6 | sc-3533 sc-3533A | 1 mg 5 mg | $88.00 $342.00 | 284 | |
SB203580 inhibits p38 MAPK, and this inhibition could lead to changes in cellular processes affecting XKR4. | ||||||
Rapamycin | 53123-88-9 | sc-3504 sc-3504A sc-3504B | 1 mg 5 mg 25 mg | $62.00 $155.00 $320.00 | 233 | |
Rapamycin inhibits mTOR, a central regulator of cell growth and metabolism, which might indirectly influence XKR4 activity. | ||||||