XAP2 Activators
XAP2 Activators are a collection of chemical compounds that facilitate the functional activity of XAP2 through their interaction with the aryl hydrocarbon receptor (AhR) signaling pathway. Compounds like FICZ, a natural AhR ligand, and synthetic inducers like β-Naphthoflavone and TCDD bind to AhR, promoting the nuclear translocation of the AhR/XAP2 complex, thus enhancing XAP2's role in gene transcription. Indole-3-carbinol and its derivative DIM, as well as metabolites like Kynurenine, modulate the AhR pathway, impacting XAP2 activity by influencing the receptor complex dynamics. Similarly, dietary phytochemicals such as Resveratrol and Curcumin, and the flavonoids Flavone and Chrysin, interact with AhR signaling, which can result in the modified activity of XAP2 by altering the AhR/XAP2 interaction.
Furthermore, Omeprazole's ability to modulate AhR signaling addsto the dynamic regulation of XAP2. The pharmaceutical modulation of AhR by Omeprazole indicates a potential route for indirectly increasing XAP2 activity through the perturbation of its associated receptor complex. Genistein's multifaceted role in cellular signaling extends to the AhR pathway, wherein its isoflavone structure can facilitate changes in AhR/XAP2 complex function, underlining its capacity to act as a XAP2 activator.
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
6-Formylindolo[3,2-b]carbazole | 172922-91-7 | sc-300019A sc-300019 | 100 µg 5 mg | $105.00 $2185.00 | 5 | |
As an endogenous ligand for AhR, FICZ binding to AhR can lead to the translocation of the AhR/XAP2 complex into the nucleus, enhancing XAP2's functional activity in gene transcription regulation. | ||||||
Indole-3-carbinol | 700-06-1 | sc-202662 sc-202662A sc-202662B sc-202662C sc-202662D | 1 g 5 g 100 g 250 g 1 kg | $39.00 $61.00 $146.00 $312.00 $1032.00 | 5 | |
Metabolite of cruciferous vegetables that can modulate AhR signaling; its derivatives may promote the dissociation of AhR from the XAP2 complex, indirectly increasing XAP2's availability for other interactions. | ||||||
3,3′-Diindolylmethane | 1968-05-4 | sc-204624 sc-204624A sc-204624B sc-204624C sc-204624D sc-204624E | 100 mg 500 mg 5 g 10 g 50 g 1 g | $37.00 $65.00 $89.00 $421.00 $681.00 $66.00 | 8 | |
Product of indole-3-carbinol digestion which acts on AhR; it can activate the receptor and potentially alter the functional state of XAP2 by changing its interaction dynamics with AhR. | ||||||
β-Naphthoflavone | 6051-87-2 | sc-205597 sc-205597A sc-205597B sc-205597C | 1 g 5 g 25 g 100 g | $33.00 $129.00 $599.00 $1647.00 | 2 | |
A synthetic flavone and a potent inducer of AhR; it can modulate the pathway by binding to AhR and potentially altering the conformation and activity of the AhR/XAP2 complex. | ||||||
Resveratrol | 501-36-0 | sc-200808 sc-200808A sc-200808B | 100 mg 500 mg 5 g | $80.00 $220.00 $460.00 | 64 | |
A polyphenolic compound that has been shown to interact with AhR signaling; it can indirectly influence XAP2 activity via modulation of the AhR pathway. | ||||||
Curcumin | 458-37-7 | sc-200509 sc-200509A sc-200509B sc-200509C sc-200509D sc-200509F sc-200509E | 1 g 5 g 25 g 100 g 250 g 1 kg 2.5 kg | $37.00 $69.00 $109.00 $218.00 $239.00 $879.00 $1968.00 | 47 | |
A compound found in turmeric that interacts with multiple signaling pathways; it can affect AhR-mediated processes, thereby potentially altering the functional role of XAP2. | ||||||
Omeprazole | 73590-58-6 | sc-202265 | 50 mg | $67.00 | 4 | |
Proton pump inhibitor that has been shown to modulate AhR signaling; this can lead to an indirect enhancement of XAP2's functional role in the cell. | ||||||
Flavone | 525-82-6 | sc-206027 sc-206027A | 1 g 5 g | $23.00 $68.00 | ||
As a plant secondary metabolite, flavone can modulate AhR signaling which may result in the altered activity of the AhR/XAP2 complex. | ||||||
Chrysin | 480-40-0 | sc-204686 | 1 g | $38.00 | 13 | |
A flavonoid that affects AhR signaling; it can influence XAP2 activity by modulating the interaction between AhR and XAP2. | ||||||
Genistein | 446-72-0 | sc-3515 sc-3515A sc-3515B sc-3515C sc-3515D sc-3515E sc-3515F | 100 mg 500 mg 1 g 5 g 10 g 25 g 100 g | $45.00 $164.00 $200.00 $402.00 $575.00 $981.00 $2031.00 | 46 | |
Isoflavone that acts on various signaling pathways including AhR; it could alter the interaction between AhR and XAP2, thereby indirectly enhancing XAP2's functional activity. | ||||||