β-Naphthoflavone (CAS 6051-87-2)
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β-Naphthoflavone is a synthetic flavonoid known for its role as a potent inducer of cytochrome P450 enzymes, particularly CYP1A1, which are studied for their involvement in the metabolism of xenobiotics. This property makes it a compound of interest in toxicological research, where it is used to explore the mechanisms of biotransformation and detoxification of harmful substances. Environmental scientists utilize β-Naphthoflavone to assess the impact of environmental pollutants on wildlife, as its induction of detoxifying enzymes can serve as a biomarker for exposure to aromatic hydrocarbons. Additionally, its interaction with the aryl hydrocarbon receptor (AhR) pathway is studied to understand the regulation of gene expression in response to environmental toxins. β-Naphthoflavone also finds application in cell culture systems to study the induction of phase I detoxification enzymes, which is for understanding cellular responses to chemical stressors.
β-Naphthoflavone (CAS 6051-87-2) References
- beta-Naphthoflavone analogs as potent and soluble aryl hydrocarbon receptor agonists: improvement of solubility by disruption of molecular planarity. | Fujita, Y., et al. 2010. Bioorg Med Chem. 18: 1194-203. PMID: 20060304
- The effect of beta-naphthoflavone on the metabolism of amiodarone by hepatic and extra-hepatic microsomes. | Elsherbiny, ME., et al. 2010. Toxicol Lett. 195: 147-54. PMID: 20362646
- Suppression of beta-naphthoflavone induced CYP1A expression and lipid-peroxidation by berberine. | Chatuphonprasert, W., et al. 2011. Fitoterapia. 82: 889-95. PMID: 21624442
- beta-Naphthoflavone protects from peritonitis by reducing TNF-alpha-induced endothelial cell activation. | Hsu, SY., et al. 2015. Pharmacol Res. 102: 192-9. PMID: 26453957
- Effects of β-Naphthoflavone on Ugt1a6 and Ugt1a7 Expression in Rat Brain. | Sakakibara, Y., et al. 2016. Biol Pharm Bull. 39: 78-83. PMID: 26725430
- β-naphthoflavone interferes with cyp1c1, cox2 and IL-8 gene transcription and leukotriene B4 secretion in Atlantic cod (Gadus morhua) head kidney cells during inflammation. | Holen, E. and Olsvik, PA. 2016. Fish Shellfish Immunol. 54: 128-34. PMID: 27041667
- Enhancing bio-availability of β-naphthoflavone by supramolecular complexation with 6,6'-thiobis(methylene)-β-cyclodextrin dimer. | Choi, JM., et al. 2016. Carbohydr Polym. 151: 40-50. PMID: 27474541
- β-Naphthoflavone treatment attenuates neonatal hyperoxic lung injury in wild type and Cyp1a2-knockout mice. | Lingappan, K., et al. 2018. Toxicol Appl Pharmacol. 339: 133-142. PMID: 29180065
- β-Naphthoflavone, an exogenous ligand of aryl hydrocarbon receptor, disrupts zinc homeostasis in human hepatoma HepG2 cells. | Ishida, T. and Takechi, S. 2019. J Toxicol Sci. 44: 711-720. PMID: 31588062
- Development of organoid-based drug metabolism model. | Park, E., et al. 2019. Toxicol Appl Pharmacol. 385: 114790. PMID: 31678242
- β-Naphthoflavone and Ethanol Reverse Mitochondrial Dysfunction in A Parkinsonian Model of Neurodegeneration. | Fernandez-Abascal, J., et al. 2020. Int J Mol Sci. 21: PMID: 32486438
- Beta-naphthoflavone inhibits LPS-induced inflammation in BV-2 cells via AKT/Nrf-2/HO-1-NF-κB signaling axis. | Gao, X., et al. 2020. Immunobiology. 225: 151965. PMID: 32747020
- Aryl hydrocarbon receptor (AhR) agonist β-naphthoflavone regulated gene networks in human primary trophoblasts. | El-Dairi, R., et al. 2020. Reprod Toxicol. 96: 370-379. PMID: 32858204
- Beta-naphthoflavone and doxorubicin synergistically enhance apoptosis in human lung cancer cells by inducing doxorubicin accumulation, mitochondrial ROS generation, and JNK pathway signaling. | Hoang, DH., et al. 2022. Biochem Biophys Res Commun. 635: 37-45. PMID: 36257190
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
β-Naphthoflavone, 1 g | sc-205597 | 1 g | $32.00 | |||
β-Naphthoflavone, 5 g | sc-205597A | 5 g | $126.00 | |||
β-Naphthoflavone, 25 g | sc-205597B | 25 g | $587.00 | |||
β-Naphthoflavone, 100 g | sc-205597C | 100 g | $1615.00 |