![6-Formylindolo[3,2-b]carbazole (CAS 172922-91-7) - chemical structure image](https://media.scbt.com/product/6-formylindolo3-2-bcarbazole-172922-91-7-structure_21_72_b_217228.jpg)
![6-Formylindolo[3,2-b]carbazole (CAS 172922-91-7) - chemical structure image](https://media.scbt.com/product/6-formylindolo3-2-bcarbazole-172922-91-7-structure_21_72_t_217228.jpg "Molecular structure of 6-Formylindolo[3,2-b]carbazole, CAS Number: 172922-91-7")
Molecular structure of 6-Formylindolo[3,2-b]carbazole, CAS Number: 172922-91-7
6-Formylindolo[3,2-b]carbazole (CAS 172922-91-7)
See product citations (5)
Alternate Names:
FICZ
Application:
6-Formylindolo[3,2-b]carbazole is a high affinity aryl hydrocarbon receptor ligand
CAS Number:
172922-91-7
Purity:
≥95%
Molecular Weight:
284.31
Molecular Formula:
C19H12N2O
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
QUICK LINKS
Ordering Information
Product Citations
Description
Technical Information
Safety Information
SDS & Certificate of Analysis
6-Formylindolo[3,2-b]carbazole, a member of the carbazole family, is an aromatic heterocyclic compound renowned for its distinctive properties. 6-Formylindolo[3,2-b]carbazole has found application in a diverse range of scientific research studies. Although the complete mechanism of action for 6-Formylindolo[3,2-b]carbazole remains elusive, it is hypothesized to function as an enzyme inhibitor, particularly targeting cyclooxygenase-2 (COX-2), while also acting as an agonist for receptors such as the serotonin 5-HT2A receptor.
6-Formylindolo[3,2-b]carbazole (CAS 172922-91-7) References
- 6-Formylindolo[3,2-b]carbazole (FICZ) is a Very Minor Photoproduct of Tryptophan at Biologically Relevant Doses of UVB and Simulated Sunlight. | Youssef, A., et al. 2019. Photochem Photobiol. 95: 237-243. PMID: 29882277
- The tryptophan derivative 6-formylindolo[3,2-b]carbazole, FICZ, a dynamic mediator of endogenous aryl hydrocarbon receptor signaling, balances cell growth and differentiation. | Rannug, A. and Rannug, U. 2018. Crit Rev Toxicol. 48: 555-574. PMID: 30226107
- Anti-androgenic effect of 6-formylindolo[3,2-b]carbazole (FICZ) in LNCaP cells is mediated by the aryl hydrocarbon-androgen receptors cross-talk. | Arabnezhad, MR., et al. 2020. Steroids. 153: 108508. PMID: 31586605
- 6-Formylindolo[3,2-b]carbazole (FICZ) Enhances The Expression of Tumor Suppressor miRNAs, miR-22, miR-515-5p, and miR-124-3p in MCF-7 Cells. | Mobini, K., et al. 2020. Cell J. 22: 115-120. PMID: 31606975
- Selective cytochrome P450 1A1 but not 1B1 promoterCpG island DNA methylation by 6-formylindolo[3,2-b]carbazole (FICZ). | Ghaedi, A., et al. 2020. J Biochem Mol Toxicol. 34: e22414. PMID: 31626383
- An Endogenous Ligand of Aryl Hydrocarbon Receptor 6-Formylindolo[3,2-b]Carbazole (FICZ) Is a Signaling Molecule in Neurogenesis of Adult Hippocampal Neurons. | Keshavarzi, M., et al. 2020. J Mol Neurosci. 70: 806-817. PMID: 32040828
- The Endogenous Tryptophan-derived Photoproduct 6-formylindolo[3,2-b]carbazole (FICZ) is a Nanomolar Photosensitizer that Can be Harnessed for the Photodynamic Elimination of Skin Cancer Cells in Vitro and in Vivo. | Justiniano, R., et al. 2021. Photochem Photobiol. 97: 180-191. PMID: 32767762
- 6-Formylindolo[3,2-b]carbazole reduces apoptosis induced by benzo[a]pyrene in a mitochondrial-dependent manner. | Gan, M., et al. 2020. Cell Biol Int. 44: 2427-2437. PMID: 32808713
- Activation of aryl hydrocarbon receptor by 6-formylindolo[3,2-b]carbazole alleviated acute kidney injury by repressing inflammation and apoptosis. | Tao, S., et al. 2021. J Cell Mol Med. 25: 1035-1047. PMID: 33280241
- [6-Formylindolo[3,2-b]carbazole alleviates lipopolysaccharide-induced acute lung injury via suppressing endoplasmic reticulum stress]. | Shao, L., et al. 2021. Zhonghua Wei Zhong Bing Ji Jiu Yi Xue. 33: 150-154. PMID: 33729131
- Inhibition of 6-formylindolo[3,2-b]carbazole metabolism sensitizes keratinocytes to UVA-induced apoptosis: Implications for vemurafenib-induced phototoxicity. | Rolfes, KM., et al. 2021. Redox Biol. 46: 102110. PMID: 34418602
- 6-Formylindolo[3,2-b]carbazole, a Potent Ligand for the Aryl Hydrocarbon Receptor Produced Both Endogenously and by Microorganisms, can Either Promote or Restrain Inflammatory Responses. | Rannug, A. 2022. Front Toxicol. 4: 775010. PMID: 35295226
- Endogenous AhR agonist FICZ accumulates in rainbow trout (Oncorhynchus mykiss) alevins exposed to a mixture of two PAHs, retene and fluoranthene. | Eriksson, ANM., et al. 2022. Ecotoxicology. 31: 1382-1389. PMID: 36219374
- Intestinal Stem Cells Damaged by Deoxycholic Acid via AHR Pathway Contributes to Mucosal Barrier Dysfunction in High-Fat Feeding Mice. | Liu, L., et al. 2022. Int J Mol Sci. 23: PMID: 36555220
- Cyprinid herpesvirus 2 infection changes microbiota and metabolites in the gibel carp (Carassius auratus gibelio) midgut. | Chen, P., et al. 2022. Front Cell Infect Microbiol. 12: 1017165. PMID: 36817692
Inhibitor of:
MrgA3, and Rev-erbα.Activator of:
Ah Receptor, Arnt 1, Aryl Hydrocarbon Receptor, CAR, NOD2, Per3, and XAP2.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
6-Formylindolo[3,2-b]carbazole, 100 µg | sc-300019A | 100 µg | $105.00 | |||
6-Formylindolo[3,2-b]carbazole, 5 mg | sc-300019 | 5 mg | $2185.00 |