WWOX Inhibitors
WWOX inhibitors are a class of chemical compounds designed to specifically target and inhibit the function of the WWOX (WW domain-containing oxidoreductase) protein. WWOX is a tumor suppressor protein that contains two WW domains, which are involved in mediating protein-protein interactions, and an oxidoreductase domain. The protein plays a key role in various cellular processes, such as apoptosis, cell cycle regulation, and DNA repair, largely through its interactions with other proteins involved in these pathways. By inhibiting WWOX, these compounds interfere with its ability to bind target proteins via its WW domains or affect its enzymatic activity, which can lead to alterations in cellular signaling pathways and the regulation of cell growth and death.
The design of WWOX inhibitors typically focuses on either blocking the WW domains, which mediate interactions with proline-rich motifs in target proteins, or inhibiting the oxidoreductase activity of the protein. These inhibitors may work by binding to the WW domains, preventing WWOX from forming complexes with other regulatory proteins, or by targeting the catalytic site to modulate its enzymatic function. Structure-activity relationship (SAR) studies and molecular docking techniques are commonly employed to identify and optimize compounds that exhibit high affinity and specificity for WWOX. The study of WWOX inhibitors allows researchers to better understand the role of WWOX in key biological processes, such as signal transduction, apoptosis, and genomic stability, and how its modulation affects these pathways at a molecular level. This helps to illuminate the broader regulatory networks in which WWOX is involved and its importance in maintaining cellular homeostasis.
Items 1 to 10 of 11 total
Display:
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Trichostatin A | 58880-19-6 | sc-3511 sc-3511A sc-3511B sc-3511C sc-3511D | 1 mg 5 mg 10 mg 25 mg 50 mg | $152.00 $479.00 $632.00 $1223.00 $2132.00 | 33 | |
Trichostatin A is a histone deacetylase inhibitor that can indirectly affect WWOX expression by altering the acetylation status of histones and non-histone proteins, potentially impacting gene expression patterns involved in tumor suppression. | ||||||
Suberoylanilide Hydroxamic Acid | 149647-78-9 | sc-220139 sc-220139A | 100 mg 500 mg | $133.00 $275.00 | 37 | |
Vorinostat, another histone deacetylase inhibitor, may influence WWOX activity by modifying chromatin structure and gene expression, thereby affecting pathways related to apoptosis and tumor suppression. | ||||||
5-Azacytidine | 320-67-2 | sc-221003 | 500 mg | $280.00 | 4 | |
5-Azacytidine, a DNA methyltransferase inhibitor, can indirectly impact WWOX expression by altering the methylation status of DNA, potentially reversing aberrant gene silencing in cancer cells. | ||||||
5-Aza-2′-Deoxycytidine | 2353-33-5 | sc-202424 sc-202424A sc-202424B | 25 mg 100 mg 250 mg | $218.00 $322.00 $426.00 | 7 | |
Decitabine functions similarly to 5-Azacytidine, potentially affecting WWOX expression by modifying DNA methylation patterns, which could influence tumor suppressor pathways. | ||||||
Taxol | 33069-62-4 | sc-201439D sc-201439 sc-201439A sc-201439E sc-201439B sc-201439C | 1 mg 5 mg 25 mg 100 mg 250 mg 1 g | $41.00 $74.00 $221.00 $247.00 $738.00 $1220.00 | 39 | |
Paclitaxel, a microtubule stabilizer, can influence cell cycle progression and apoptosis, pathways in which WWOX might play a role, particularly in the context of cancer. | ||||||
Doxorubicin | 23214-92-8 | sc-280681 sc-280681A | 1 mg 5 mg | $176.00 $426.00 | 43 | |
Doxorubicin, an anthracycline antibiotic, induces DNA damage and can affect pathways involving WWOX, particularly in the context of apoptosis and cell cycle regulation. | ||||||
Curcumin | 458-37-7 | sc-200509 sc-200509A sc-200509B sc-200509C sc-200509D sc-200509F sc-200509E | 1 g 5 g 25 g 100 g 250 g 1 kg 2.5 kg | $37.00 $69.00 $109.00 $218.00 $239.00 $879.00 $1968.00 | 47 | |
Curcumin, a natural compound, has been shown to modulate multiple signaling pathways, some of which could be related to WWOX function in apoptosis and tumor suppression. | ||||||
Resveratrol | 501-36-0 | sc-200808 sc-200808A sc-200808B | 100 mg 500 mg 5 g | $80.00 $220.00 $460.00 | 64 | |
Resveratrol, a polyphenol, may affect WWOX through its action on multiple signaling pathways, including those involved in apoptosis and tumor suppression. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $123.00 $400.00 | 148 | |
LY294002, a PI3K inhibitor, may indirectly influence WWOX activity by modulating the PI3K/AKT pathway, which is involved in cell survival and apoptosis. | ||||||
Rapamycin | 53123-88-9 | sc-3504 sc-3504A sc-3504B | 1 mg 5 mg 25 mg | $63.00 $158.00 $326.00 | 233 | |
Rapamycin, an mTOR inhibitor, can impact cellular processes in which WWOX is involved, particularly in the context of cell growth, proliferation, and survival. | ||||||