Wnt-10b Inhibitors
Wnt-10b inhibitors belong to a class of chemical compounds designed to specifically target and modulate the activity of the Wnt-10b signaling pathway. The Wnt (wingless/integrated) signaling pathway is a crucial and highly conserved molecular pathway that plays a fundamental role in various biological processes, including embryonic development, tissue homeostasis, and cellular proliferation. Among the various Wnt ligands, Wnt-10b is known to be particularly involved in regulating these processes. Wnt-10b inhibitors are designed to interfere with the activity of Wnt-10b by binding to specific components of the pathway and inhibiting its downstream signaling.
At the molecular level, Wnt-10b inhibitors often target key components of the Wnt signaling cascade, such as the frizzled receptors or the β-catenin protein. By disrupting the interaction between Wnt-10b and its receptor, or by preventing the stabilization and nuclear translocation of β-catenin, these inhibitors effectively downregulate Wnt-10b signaling. This, in turn, can have profound effects on cellular processes, including gene expression patterns and cell fate determination. The development and utilization of Wnt-10b inhibitors have provided researchers with a valuable tool for elucidating the intricacies of Wnt signaling in both normal and pathological contexts. These inhibitors have also garnered significant attention in the field of regenerative medicine and tissue engineering, as understanding and manipulating Wnt-10b signaling can be critical for controlling stem cell behavior and tissue regeneration.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Nitazoxanide | 55981-09-4 | sc-212397 | 10 mg | $122.00 | 1 | |
Primarily known as an antiparasitic drug, Nitazoxanide has been reported to inhibit the Wnt/β-catenin signaling pathway. While its exact mechanism regarding Wnt inhibition isn′t fully understood, it might act on the pathway by affecting Wnt-related proteins, though it hasn′t been explicitly verified for Wnt 10b. | ||||||
Quercetin | 117-39-5 | sc-206089 sc-206089A sc-206089E sc-206089C sc-206089D sc-206089B | 100 mg 500 mg 100 g 250 g 1 kg 25 g | $11.00 $17.00 $108.00 $245.00 $918.00 $49.00 | 33 | |
Quercetin may decrease Wnt-10b expression through its antioxidant properties and ability to modulate various signaling pathways. | ||||||
Curcumin | 458-37-7 | sc-200509 sc-200509A sc-200509B sc-200509C sc-200509D sc-200509F sc-200509E | 1 g 5 g 25 g 100 g 250 g 1 kg 2.5 kg | $36.00 $68.00 $107.00 $214.00 $234.00 $862.00 $1968.00 | 47 | |
Curcumin has been shown to modulate Wnt signaling pathways, potentially reducing Wnt-10b expression. Its anti-inflammatory and antioxidant properties may contribute to its ability to influence these pathways. | ||||||
IWP-2 | 686770-61-6 | sc-252928 sc-252928A | 5 mg 25 mg | $94.00 $286.00 | 27 | |
This is an inhibitor of the enzyme porcupine, which is necessary for the palmitoylation and subsequent secretion of Wnt ligands. By inhibiting porcupine, IWP-2 prevents Wnt proteins, possibly including Wnt 10b, from being secreted and thus reduces Wnt signaling activity. | ||||||
Resveratrol | 501-36-0 | sc-200808 sc-200808A sc-200808B | 100 mg 500 mg 5 g | $60.00 $185.00 $365.00 | 64 | |
Resveratrol can inhibit the Wnt signaling pathway, potentially leading to a decrease in Wnt-10b expression. This compound is found in grapes and berries, and is known for its antioxidant and anti-inflammatory properties. | ||||||
D,L-Sulforaphane | 4478-93-7 | sc-207495A sc-207495B sc-207495C sc-207495 sc-207495E sc-207495D | 5 mg 10 mg 25 mg 1 g 10 g 250 mg | $150.00 $286.00 $479.00 $1299.00 $8299.00 $915.00 | 22 | |
DL-Sulforaphane, found in cruciferous vegetables, has been reported to inhibit Wnt signaling, which may lead to a reduction in Wnt-10b expression. | ||||||
(−)-Epigallocatechin Gallate | 989-51-5 | sc-200802 sc-200802A sc-200802B sc-200802C sc-200802D sc-200802E | 10 mg 50 mg 100 mg 500 mg 1 g 10 g | $42.00 $72.00 $124.00 $238.00 $520.00 $1234.00 | 11 | |
(-)-Epigallocatechin Gallate, a major component of green tea, has demonstrated the ability to modulate Wnt signaling pathways, potentially influencing Wnt-10b expression. It is known for its antioxidant and anti-inflammatory effects. | ||||||
Retinoic Acid, all trans | 302-79-4 | sc-200898 sc-200898A sc-200898B sc-200898C | 500 mg 5 g 10 g 100 g | $65.00 $319.00 $575.00 $998.00 | 28 | |
Retinoic acid, a derivative of vitamin A, has been shown to modulate Wnt signaling pathways. This may result in altered Wnt-10b expression levels, contributing to its role in cell differentiation and growth. | ||||||
Pyrvinium Pamoate | 3546-41-6 | sc-476920A sc-476920 | 250 mg 500 mg | $224.00 $414.00 | ||
This compound has been identified as a potent inhibitor of the Wnt/β-catenin signaling pathway. It is believed to act by enhancing the degradation of β-catenin. As with the other compounds, while it can influence the Wnt pathway, specificity for Wnt 10b is not clearly mentioned. | ||||||
Genistein | 446-72-0 | sc-3515 sc-3515A sc-3515B sc-3515C sc-3515D sc-3515E sc-3515F | 100 mg 500 mg 1 g 5 g 10 g 25 g 100 g | $26.00 $92.00 $120.00 $310.00 $500.00 $908.00 $1821.00 | 46 | |
Genistein, a phytoestrogen found in soy, can modulate various signaling pathways, including Wnt signaling, potentially leading to changes in Wnt-10b expression. It is known for its antioxidant properties. | ||||||