WDR90 Activators
The chemical class of WDR90 activators comprises a diverse group of molecules that regulate WDR90 expression and activity through various signaling pathways. These activators can modulate transcription factors, such as NF-κB, which play pivotal roles in regulating WDR90 expression. For instance, retinoic acid, forskolin, and curcumin activate WDR90 by influencing the activity of transcription factors that bind to the promoter region of the WDR90 gene, leading to its transcriptional activation.
Moreover, these activators can also indirectly influence WDR90 expression by modulating other signaling pathways involved in WDR90 regulation. For example, compounds like berberine, genistein, and sulforaphane activate WDR90 by inhibiting NF-κB signaling, which normally represses WDR90 expression. By blocking NF-κB activity, these compounds upregulate WDR90 expression, leading to its activation. Overall, the chemical class of WDR90 activators encompasses molecules that can modulate various signaling pathways to regulate WDR90 expression and activity, thereby influencing cellular processes in which WDR90 is involved.
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Items 1 to 10 of 12 total
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Retinoic Acid, all trans | 302-79-4 | sc-200898 sc-200898A sc-200898B sc-200898C | 500 mg 5 g 10 g 100 g | $65.00 $319.00 $575.00 $998.00 | 28 | |
Retinoic acid activates WDR90 by binding to retinoic acid receptors (RARs), which then heterodimerize with retinoid X receptors (RXRs). This complex acts as a transcription factor, binding to retinoic acid response elements (RAREs) in the promoter region of WDR90, leading to its transcriptional activation. | ||||||
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $76.00 $150.00 $725.00 $1385.00 $2050.00 | 73 | |
Forskolin activates WDR90 by stimulating adenylate cyclase, leading to increased levels of cyclic adenosine monophosphate (cAMP). Elevated cAMP levels activate protein kinase A (PKA), which phosphorylates transcription factors, including those involved in the regulation of WDR90 expression, leading to its activation. | ||||||
Curcumin | 458-37-7 | sc-200509 sc-200509A sc-200509B sc-200509C sc-200509D sc-200509F sc-200509E | 1 g 5 g 25 g 100 g 250 g 1 kg 2.5 kg | $36.00 $68.00 $107.00 $214.00 $234.00 $862.00 $1968.00 | 47 | |
Curcumin activates WDR90 by modulating various signaling pathways involved in inflammation and cell survival. It can inhibit NF-κB signaling, which represses WDR90 expression, thereby indirectly activating WDR90. Additionally, curcumin can modulate other signaling pathways that regulate WDR90 expression, leading to its activation. | ||||||
Berberine | 2086-83-1 | sc-507337 | 250 mg | $90.00 | 1 | |
Berberine activates WDR90 by inhibiting NF-κB signaling, which normally suppresses WDR90 expression. By blocking NF-κB activity, berberine indirectly upregulates WDR90 expression, leading to its activation. Berberine also modulates other signaling pathways involved in WDR90 regulation, further contributing to its activation. | ||||||
(−)-Epigallocatechin Gallate | 989-51-5 | sc-200802 sc-200802A sc-200802B sc-200802C sc-200802D sc-200802E | 10 mg 50 mg 100 mg 500 mg 1 g 10 g | $42.00 $72.00 $124.00 $238.00 $520.00 $1234.00 | 11 | |
EGCG activates WDR90 by inhibiting NF-κB signaling, which negatively regulates WDR90 expression. By suppressing NF-κB activity, EGCG indirectly upregulates WDR90 expression, leading to its activation. EGCG also modulates other signaling pathways involved in WDR90 regulation, contributing to its activation. | ||||||
Resveratrol | 501-36-0 | sc-200808 sc-200808A sc-200808B | 100 mg 500 mg 5 g | $60.00 $185.00 $365.00 | 64 | |
Resveratrol activates WDR90 by inhibiting NF-κB signaling, which normally represses WDR90 expression. By blocking NF-κB activity, resveratrol indirectly upregulates WDR90 expression, leading to its activation. Resveratrol can also modulate other signaling pathways involved in WDR90 regulation, further contributing to its activation. | ||||||
Genistein | 446-72-0 | sc-3515 sc-3515A sc-3515B sc-3515C sc-3515D sc-3515E sc-3515F | 100 mg 500 mg 1 g 5 g 10 g 25 g 100 g | $26.00 $92.00 $120.00 $310.00 $500.00 $908.00 $1821.00 | 46 | |
Genistein activates WDR90 by inhibiting NF-κB signaling, which suppresses WDR90 expression. By blocking NF-κB activity, genistein indirectly upregulates WDR90 expression, leading to its activation. Genistein also modulates other signaling pathways involved in WDR90 regulation, further contributing to its activation. | ||||||
D,L-Sulforaphane | 4478-93-7 | sc-207495A sc-207495B sc-207495C sc-207495 sc-207495E sc-207495D | 5 mg 10 mg 25 mg 1 g 10 g 250 mg | $150.00 $286.00 $479.00 $1299.00 $8299.00 $915.00 | 22 | |
Sulforaphane activates WDR90 by inhibiting NF-κB signaling, which downregulates WDR90 expression. By suppressing NF-κB activity, sulforaphane indirectly upregulates WDR90 expression, leading to its activation. Sulforaphane also modulates other signaling pathways involved in WDR90 regulation, contributing to its activation. | ||||||
Quercetin | 117-39-5 | sc-206089 sc-206089A sc-206089E sc-206089C sc-206089D sc-206089B | 100 mg 500 mg 100 g 250 g 1 kg 25 g | $11.00 $17.00 $108.00 $245.00 $918.00 $49.00 | 33 | |
Quercetin activates WDR90 by inhibiting NF-κB signaling, which inhibits WDR90 expression. By blocking NF-κB activity, quercetin indirectly upregulates WDR90 expression, leading to its activation. Quercetin can also modulate other signaling pathways involved in WDR90 regulation, further contributing to its activation. | ||||||
Lycopene | 502-65-8 | sc-205738 sc-205738A sc-205738B | 1 mg 5 mg 1 g | $143.00 $571.00 $6125.00 | 4 | |
Lycopene activates WDR90 by inhibiting NF-κB signaling, which normally suppresses WDR90 expression. By blocking NF-κB activity, lycopene indirectly upregulates WDR90 expression, leading to its activation. Lycopene also modulates other signaling pathways involved in WDR90 regulation, further contributing to its activation. | ||||||