WDR90 Inhibitors
PI3K inhibitors such as Wortmannin and LY294002 interrupt signal transduction events that can have downstream effects on protein sorting and trafficking, processes that are essential for the function and regulation of WDR90 within the cell. Similarly, the inhibition of kinases like MEK with U0126 or p38 MAPK with SB203580 can disrupt signaling networks that modulate cellular responses to external stimuli, protein synthesis, and degradation mechanisms. These changes can influence the cellular locale and activity of WDR90, altering its role in the maintenance of cellularThe chemical class named WDR90 inhibitors represents a collection of compounds that indirectly modulate the function of the WDR90 protein. These inhibitors achieve their effects by targeting various cellular signaling pathways and processes which are connected to the biological role of WDR90. The chemicals in this class are recognized not for their direct interaction with WDR90, but rather for their capacity to alter the cellular milieu in which WDR90 operates.
The inhibitors exert their influence on WDR90 by one of several mechanisms. Some, like Wortmannin and LY294002, are known to inhibit PI3K, an upstream regulator that influences a plethora of cellular functions including protein trafficking and sorting, which are processes wherein WDR90 might be involved. Others, such as U0126 and PD98059, target the MAPK/ERK pathway, which is integral for cell signaling related to growth and differentiation. By disrupting this pathway, these inhibitors can affect the cellular functions where WDR90 is potentially engaged. Inhibitors like SB203580 and SP600125, which hinder the activity of p38 MAPK and JNK respectively, can alter the cellular response to stress, potentially impacting WDR90's function related to cellular homeostasis and stress responses.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Wortmannin | 19545-26-7 | sc-3505 sc-3505A sc-3505B | 1 mg 5 mg 20 mg | $66.00 $219.00 $417.00 | 97 | |
Wortmannin is a steroidal metabolite that acts as a potent inhibitor of phosphoinositide 3-kinases (PI3K), which can alter cellular processes including those associated with vesicle trafficking and protein sorting, pathways where WDR90 is implicated. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $121.00 $392.00 | 148 | |
LY294002 is a chemical inhibitor of PI3K, leading to disruptions in PI3K/AKT signaling, which can affect downstream proteins involved in endosomal sorting, potentially modulating the function of WDR90 in cellular protein trafficking. | ||||||
U-0126 | 109511-58-2 | sc-222395 sc-222395A | 1 mg 5 mg | $63.00 $241.00 | 136 | |
U0126 is a selective inhibitor of mitogen-activated protein kinase kinase (MEK), which can interfere with the MAPK/ERK pathway, affecting proteins that interact with this pathway, including those involved in vesicle formation and trafficking where WDR90 may play a part. | ||||||
SB 203580 | 152121-47-6 | sc-3533 sc-3533A | 1 mg 5 mg | $88.00 $342.00 | 284 | |
SB203580 selectively inhibits p38 MAPK, a key mediator in cellular stress response. By hindering this pathway, it can influence proteins associated with stress-induced cellular processes, potentially affecting WDR90's role in cellular homeostasis. | ||||||
Rapamycin | 53123-88-9 | sc-3504 sc-3504A sc-3504B | 1 mg 5 mg 25 mg | $62.00 $155.00 $320.00 | 233 | |
Rapamycin is an mTOR inhibitor that can disrupt mTOR signaling, impacting protein synthesis and degradation. This can lead to alterations in cellular growth processes where WDR90 might be involved. | ||||||
Bortezomib | 179324-69-7 | sc-217785 sc-217785A | 2.5 mg 25 mg | $132.00 $1064.00 | 115 | |
Bortezomib is a proteasome inhibitor that can prevent the degradation of ubiquitinated proteins, possibly affecting the turnover and function of WDR90 as it relates to protein stability and degradation. | ||||||
PD 98059 | 167869-21-8 | sc-3532 sc-3532A | 1 mg 5 mg | $39.00 $90.00 | 212 | |
PD98059 is a MAPK/ERK pathway inhibitor that can prevent the activation of ERK kinases, which can alter the function of proteins that interact with this signaling pathway, including those involved in molecular sorting where WDR90 may be implicated. | ||||||
SP600125 | 129-56-6 | sc-200635 sc-200635A | 10 mg 50 mg | $40.00 $150.00 | 257 | |
SP600125 is an inhibitor of the c-Jun N-terminal kinase (JNK), which can affect stress response pathways and proteins that are regulated by these pathways, including WDR90 if involved in stress-related cellular processes. | ||||||
MG-132 [Z-Leu- Leu-Leu-CHO] | 133407-82-6 | sc-201270 sc-201270A sc-201270B | 5 mg 25 mg 100 mg | $56.00 $260.00 $980.00 | 163 | |
MG-132 is a proteasome inhibitor that can lead to the accumulation of proteins marked for degradation, which can influence the function of proteins involved in proteasomal degradation pathways, such as WDR90. | ||||||
CAY10512 | 139141-12-1 | sc-205237 sc-205237A | 10 mg 100 mg | $67.00 $539.00 | ||
This inhibitor prevents the activation of NF-κB, a transcription factor, which can alter the expression of proteins that depend on NF-κB-mediated transcription, potentially influencing WDR90's expression if it is regulated by this pathway. | ||||||