WDR90 Activators

The chemical class of WDR90 activators comprises a diverse group of molecules that regulate WDR90 expression and activity through various signaling pathways. These activators can modulate transcription factors, such as NF-κB, which play pivotal roles in regulating WDR90 expression. For instance, retinoic acid, forskolin, and curcumin activate WDR90 by influencing the activity of transcription factors that bind to the promoter region of the WDR90 gene, leading to its transcriptional activation.

Moreover, these activators can also indirectly influence WDR90 expression by modulating other signaling pathways involved in WDR90 regulation. For example, compounds like berberine, genistein, and sulforaphane activate WDR90 by inhibiting NF-κB signaling, which normally represses WDR90 expression. By blocking NF-κB activity, these compounds upregulate WDR90 expression, leading to its activation. Overall, the chemical class of WDR90 activators encompasses molecules that can modulate various signaling pathways to regulate WDR90 expression and activity, thereby influencing cellular processes in which WDR90 is involved.