VPS37C Inhibitors
Chemical inhibitors of VPS37C employ various mechanisms to disrupt the protein's function, which is integral to the endosomal trafficking system within cells. Concanamycin A and Bafilomycin A1 target the vacuolar type H+-ATPase (V-ATPase), inhibiting the acidification of endosomes and lysosomes. This inhibition raises the pH within these organelles, thereby impeding VPS37C's role in the endocytic pathway, as the protein relies on a certain acidic environment to mediate vesicular trafficking. Similarly, Chloroquine and its analogue Hydroxychloroquine, along with NH4Cl, also disrupt the acidic environment within endosomes and lysosomes. By increasing the pH, these chemicals interfere with the normal function of VPS37C, which is contingent on the organelle's acidity for sorting and trafficking processes.
Other inhibitors, such as Dynasore and MiTMAB, act by targeting dynamin, a GTPase essential for the detachment of clathrin-coated vesicles from the membrane. Inhibiting dynamin function prevents the proper formation of endosomal vesicles, which indirectly affects VPS37C by hindering the vesicle's trafficking and delivery to their designated locations within the cell. Monodansylcadaverine, while primarily known as an autophagic marker, also plays a role in inhibiting VPS37C by disrupting the autophagic process, which can be connected to the endosomal sorting and trafficking. Genistein, by inhibiting tyrosine kinases, affects signaling pathways that can modulate endocytic trafficking, and thus, could indirectly modulate the activity of VPS37C. Wortmannin and LY294002, both PI3K inhibitors, disrupt early endosomal trafficking by impeding the endosomal sorting complex required for transport (ESCRT) machinery, which is essential for VPS37C's function in sorting proteins within endosomes. Lastly, EIPA, by preventing the re-acidification of intracellular organelles, alters the endosomal pH, thereby disrupting the functional environment necessary for VPS37C's role in protein sorting and trafficking.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Concanamycin A | 80890-47-7 | sc-202111 sc-202111A sc-202111B sc-202111C | 50 µg 200 µg 1 mg 5 mg | $66.00 $167.00 $673.00 $2601.00 | 109 | |
Concanamycin A, a vacuolar type H+-ATPase (V-ATPase) inhibitor, can inhibit the acidification of endosomes. Since VPS37C is involved in endosomal trafficking, by elevating the pH within endosomes, Concanamycin A disrupts the endocytic pathway, thereby functionally inhibiting VPS37C's role in this process. | ||||||
Bafilomycin A1 | 88899-55-2 | sc-201550 sc-201550A sc-201550B sc-201550C | 100 µg 1 mg 5 mg 10 mg | $98.00 $255.00 $765.00 $1457.00 | 280 | |
Bafilomycin A1, another V-ATPase inhibitor, works similarly to Concanamycin A. It prevents the acidification of endosomes and lysosomes. This hinders the normal function of VPS37C by disrupting the environment needed for the protein's role in vesicular trafficking from endosomes to other cellular compartments. | ||||||
Dynamin Inhibitor I, Dynasore | 304448-55-3 | sc-202592 | 10 mg | $89.00 | 44 | |
Dynasore is a GTPase inhibitor that targets dynamin, which is crucial for the scission of clathrin-coated vesicles from the membrane. Inhibiting dynamin function can indirectly inhibit VPS37C by preventing the proper formation and trafficking of endosomal vesicles where VPS37C operates. | ||||||
Dansylcadaverine | 10121-91-2 | sc-214851 sc-214851A sc-214851B | 100 mg 250 mg 1 g | $52.00 $89.00 $240.00 | 4 | |
Monodansylcadaverine is an inhibitor of transglutaminase and also acts as a marker for autophagic vacuoles. By inhibiting autophagic processes, it can affect the recycling of cellular components, indirectly inhibiting the function of VPS37C in the autophagic pathway. | ||||||
Chloroquine | 54-05-7 | sc-507304 | 250 mg | $69.00 | 2 | |
Chloroquine is known to inhibit lysosomal enzymes and can raise the pH in endosomes and lysosomes, impairing the endosome-lysosome pathway. This can functionally inhibit VPS37C by disrupting the normal trafficking and processing of proteins within these cellular compartments. | ||||||
Ammonium Chloride | 12125-02-9 | sc-202936 sc-202936A sc-202936B | 25 g 500 g 2.5 kg | $39.00 $55.00 $150.00 | 4 | |
Ammonium chloride (NH4Cl) functions similarly to Chloroquine. It raises the pH in acidic organelles like lysosomes and endosomes, which can result in the functional inhibition of VPS37C by disrupting the endosomal-lysosomal trafficking necessary for its function. | ||||||
Genistein | 446-72-0 | sc-3515 sc-3515A sc-3515B sc-3515C sc-3515D sc-3515E sc-3515F | 100 mg 500 mg 1 g 5 g 10 g 25 g 100 g | $45.00 $164.00 $200.00 $402.00 $575.00 $981.00 $2031.00 | 46 | |
Genistein is a tyrosine kinase inhibitor that can interfere with signaling pathways. Since tyrosine phosphorylation can regulate endocytic trafficking, Genistein can indirectly inhibit VPS37C by altering the signaling required for the sorting and trafficking of vesicular compartments. | ||||||
Wortmannin | 19545-26-7 | sc-3505 sc-3505A sc-3505B | 1 mg 5 mg 20 mg | $67.00 $223.00 $425.00 | 97 | |
Wortmannin is a potent inhibitor of phosphoinositide 3-kinases (PI3K). Since PI3K activity is involved in early endosomal trafficking, its inhibition can disrupt the endosomal sorting complex required for transport (ESCRT) machinery, thereby inhibiting the function of VPS37C in endosomal sorting. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $123.00 $400.00 | 148 | |
LY294002, like Wortmannin, is also an inhibitor of PI3K. The inhibition of PI3K can lead to dysfunction in the formation and maturation of endosomes, which can functionally inhibit VPS37C by disrupting its role in the endosomal sorting process. | ||||||
hydroxychloroquine | 118-42-3 | sc-507426 | 5 g | $57.00 | 1 | |
Hydroxychloroquine, similar to Chloroquine and NH4Cl, inhibits lysosomal enzymes and raises endosomal and lysosomal pH. This can inhibit VPS37C by disrupting the acidic environment required for its role in endosomal trafficking. | ||||||