Vmn1r159 Inhibitors
Vmn1r159 inhibitors encompass a range of chemicals that indirectly affect the function of the vomeronasal 1 receptor 159 by targeting various signaling pathways and cellular processes that are either part of the receptor's signaling cascade or can modulate its activity. These compounds include neurotransmitter agonists, calcium signaling modulators, kinase inhibitors, and antagonists of various receptor types. For example, Carbachol, through its non-selective activation of muscarinic receptors, can initiate cellular responses that counteract or override the signaling initiated by Vmn1r159.
The inhibitors in this class alter intracellular signaling cascades and second messenger systems that are crucial for the normal function of Vmn1r159. BAPTA-AM, by chelating intracellular calcium, can disrupt the calcium-dependent signaling pathways on which Vmn1r159 may rely. Kinase inhibitors like PD 98059, SB 203580, SP600125, U0126, and PP2 disrupt specific kinase pathways (MEK, p38 MAPK, JNK, and Src family kinases, respectively) that are integral to the regulation of receptor-mediated cellular responses. LY294002 and AG 1478, targeting PI3K and EGFR tyrosine kinases, respectively, can interrupt the broader signaling networks that may contribute to the functional outcomes of Vmn1r159 activation.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Carbachol | 51-83-2 | sc-202092 sc-202092A sc-202092C sc-202092D sc-202092B sc-202092E | 1 g 10 g 25 g 50 g 100 g 250 g | $122.00 $281.00 $388.00 $683.00 $1428.00 $3060.00 | 12 | |
A cholinergic agonist that can non-selectively activate muscarinic cholinergic receptors, potentially causing a downstream effect that inhibits Vmn1r159 signaling. | ||||||
BAPTA/AM | 126150-97-8 | sc-202488 sc-202488A | 25 mg 100 mg | $138.00 $458.00 | 61 | |
A cell-permeable calcium chelator that can diminish intracellular calcium levels, potentially affecting calcium-dependent processes of Vmn1r159 signaling. | ||||||
Suramin sodium | 129-46-4 | sc-507209 sc-507209F sc-507209A sc-507209B sc-507209C sc-507209D sc-507209E | 50 mg 100 mg 250 mg 1 g 10 g 25 g 50 g | $152.00 $214.00 $728.00 $2601.00 $10965.00 $21838.00 $41096.00 | 5 | |
A non-selective P2 purinergic antagonist that can disrupt purinergic signaling, potentially influencing Vmn1r159 receptor pathways. | ||||||
2-APB | 524-95-8 | sc-201487 sc-201487A | 20 mg 100 mg | $28.00 $53.00 | 37 | |
A modulator of IP3 receptors and store-operated channels that can alter calcium release from the endoplasmic reticulum, potentially affecting Vmn1r159 signaling. | ||||||
SK&F 96365 | 130495-35-1 | sc-201475 sc-201475B sc-201475A sc-201475C | 5 mg 10 mg 25 mg 50 mg | $103.00 $158.00 $397.00 $656.00 | 2 | |
An inhibitor of receptor-mediated calcium entry channels, which can affect calcium signaling pathways linked to Vmn1r159. | ||||||
PD 98059 | 167869-21-8 | sc-3532 sc-3532A | 1 mg 5 mg | $40.00 $92.00 | 212 | |
An inhibitor of MEK, which can disrupt the MAPK/ERK signaling pathway, potentially influencing Vmn1r159 receptor function. | ||||||
SB 203580 | 152121-47-6 | sc-3533 sc-3533A | 1 mg 5 mg | $90.00 $349.00 | 284 | |
An inhibitor of p38 MAPK, which can modulate inflammatory signaling pathways that may indirectly affect Vmn1r159 signaling. | ||||||
SP600125 | 129-56-6 | sc-200635 sc-200635A | 10 mg 50 mg | $40.00 $150.00 | 257 | |
An inhibitor of the JNK pathway, which can alter stress response signaling pathways potentially linked to Vmn1r159. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $123.00 $400.00 | 148 | |
A PI3K inhibitor that can disrupt phosphatidylinositol signaling, potentially affecting the function of Vmn1r159. | ||||||
PP 2 | 172889-27-9 | sc-202769 sc-202769A | 1 mg 5 mg | $94.00 $227.00 | 30 | |
An Src family tyrosine kinase inhibitor that can affect tyrosine kinase-dependent signaling pathways, potentially influencing Vmn1r159. | ||||||