Vmn1r114 Activators
Vomeronasal 1 receptor 114 activators are a collection of chemical compounds that enhance the functional activity of the receptor through various signaling pathways. Chemicals such as Calcium Ionophore A23187 and Ionomycin increase intracellular calcium, a crucial second messenger that directly activates vomeronasal 1 receptor 114. Forskolin and IBMX work through the cAMP pathway; forskolin by activating adenylyl cyclase to produce cAMP, and IBMX by inhibiting phosphodiesterases, preventing cAMP degradation, both leading to enhanced activity of vomeronasal 1 receptor 114. Activation of protein kinase C by compounds like Phorbol 12-myristate 13-acetate can phosphorylate GPCRs, suggesting a potential enhancement of vomeronasal 1 receptor 114 activity.
Further, the activity of G-proteins is pivotal for the function of GPCRs like vomeronasal 1 receptor 114. Compounds such as Sodium Fluoride and Cholera Toxin act as G-protein activators, with the latter specifically increasing cAMP levels by activating the Gs alpha subunit, enhancing receptor activity. Conversely, Pertussis Toxin's inhibition of Gi alpha subunits leads to increased cAMP, indirectly enhancing receptor activity. Beta-adrenergic agonists like Isoproterenol also raise cAMP levels, further substantiating the role of this second messenger in the activation of vomeronasal 1 receptor 114.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
A23187 | 52665-69-7 | sc-3591 sc-3591B sc-3591A sc-3591C | 1 mg 5 mg 10 mg 25 mg | $55.00 $131.00 $203.00 $317.00 | 23 | |
Calcium ionophore that increases intracellular calcium concentration. Vomeronasal 1 receptor 114 is activated by changes in calcium levels, thus A23187 directly enhances its activity through calcium-mediated signaling. | ||||||
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $41.00 $132.00 $214.00 $500.00 $948.00 | 119 | |
Activator of protein kinase C (PKC) that can modulate G-protein-coupled receptor (GPCR) function. Vomeronasal 1 receptor 114, being a GPCR, has its activity enhanced through PKC-mediated signaling pathways. | ||||||
Ionomycin | 56092-82-1 | sc-3592 sc-3592A | 1 mg 5 mg | $78.00 $270.00 | 80 | |
Calcium ionophore that selectively transports calcium across membranes, increasing intracellular calcium. This directly enhances vomeronasal 1 receptor 114 activity via calcium-dependent signaling mechanisms. | ||||||
IBMX | 28822-58-4 | sc-201188 sc-201188B sc-201188A | 200 mg 500 mg 1 g | $260.00 $350.00 $500.00 | 34 | |
Non-selective inhibitor of phosphodiesterases (PDEs) leading to increased cAMP levels. Elevated cAMP can enhance vomeronasal 1 receptor 114 signaling through cAMP-dependent protein kinase (PKA) pathways. | ||||||
Sodium Fluoride | 7681-49-4 | sc-24988A sc-24988 sc-24988B | 5 g 100 g 500 g | $40.00 $46.00 $100.00 | 26 | |
G-protein activator that can stimulate GPCR signaling. Vomeronasal 1 receptor 114's function is directly enhanced by the activation of its associated G-proteins, thereby influencing intracellular signaling cascades. | ||||||
Pertussis Toxin (islet-activating protein) | 70323-44-3 | sc-200837 | 50 µg | $451.00 | 3 | |
Inhibitor of Gi alpha subunits, leading to increased intracellular cAMP levels. It indirectly enhances vomeronasal 1 receptor 114 activity through disinhibition of cAMP accumulation. | ||||||
Isoproterenol Hydrochloride | 51-30-9 | sc-202188 sc-202188A | 100 mg 500 mg | $28.00 $38.00 | 5 | |
Beta-adrenergic receptor agonist that increases cAMP levels via Gs protein stimulation. Increased cAMP enhances vomeronasal 1 receptor 114 activity through the cAMP signaling pathway. | ||||||
Adenosine | 58-61-7 | sc-291838 sc-291838A sc-291838B sc-291838C sc-291838D sc-291838E sc-291838F | 1 g 5 g 100 g 250 g 1 kg 5 kg 10 kg | $34.00 $48.00 $300.00 $572.00 $1040.00 $2601.00 $4682.00 | 1 | |
Activates adenosine receptors, leading to varied intracellular responses including changes in cAMP levels which can enhance the activity of vomeronasal 1 receptor 114. | ||||||
L-Arginine | 74-79-3 | sc-391657B sc-391657 sc-391657A sc-391657C sc-391657D | 5 g 25 g 100 g 500 g 1 kg | $20.00 $31.00 $61.00 $219.00 $352.00 | 2 | |
Precursor of nitric oxide synthesis. Nitric oxide can act as a second messenger and modulate GPCR signaling, thereby enhancing the function of vomeronasal 1 receptor 114. | ||||||