VDAC2 Activators
Voltage-dependent anion-selective channel 2 (VDAC2) is a crucial mitochondrial protein involved in regulating the transport of ions, metabolites, and energy metabolites across the mitochondrial outer membrane. As a key component of the mitochondrial permeability transition pore (mPTP), VDAC2 plays a critical role in mitochondrial physiology, cell survival, and apoptosis regulation. Its primary function lies in facilitating the exchange of small molecules, such as ATP, ADP, NADH, and calcium ions, between the cytosol and the mitochondrial intermembrane space. This exchange is fundamental for various cellular processes, including oxidative phosphorylation, apoptosis, and cell metabolism regulation. Moreover, VDAC2 also interacts with several proteins involved in apoptosis regulation, including members of the Bcl-2 family, further highlighting its importance in cell fate determination.
Activation of VDAC2 primarily occurs through post-translational modifications, such as phosphorylation, acetylation, and redox modifications, which can modulate its conformation and activity. Additionally, various signaling pathways, including those mediated by kinases and metabolic regulators, can influence VDAC2 activity. For instance, activation of protein kinase A (PKA) has been shown to enhance VDAC2 conductance, promoting the release of cytochrome c and triggering apoptotic pathways. Similarly, changes in the cellular redox state, mediated by reactive oxygen species (ROS), can modulate VDAC2 activity, impacting mitochondrial function and cell survival. Additionally, alterations in intracellular calcium levels can regulate VDAC2 opening, influencing mitochondrial membrane potential and calcium homeostasis. Overall, the activation of VDAC2 represents a complex interplay of various cellular signaling pathways and post-translational modifications, ultimately impacting mitochondrial function and cellular fate.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Clofilium tosylate | 92953-10-1 | sc-391228 sc-391228A | 25 mg 100 mg | $428.00 $1020.00 | 1 | |
Clofilium is a class III antiarrhythmic agent that blocks various potassium channels, including hERG. Its influence on mitochondrial potassium channels suggests a potential role in VDAC2 modulation. By affecting mitochondrial function, Clofilium may indirectly impact VDAC2 activity. | ||||||
Lonidamine | 50264-69-2 | sc-203115 sc-203115A | 5 mg 25 mg | $103.00 $357.00 | 7 | |
Lonidamine, an indazole carboxylic acid derivative, disrupts mitochondrial respiration and ATP production. Its impact on mitochondrial function may lead to alterations in VDAC2 activity. Lonidamine serves as a tool to investigate the link between mitochondrial bioenergetics and VDAC2 regulation. | ||||||
Mdivi-1 | 338967-87-6 | sc-215291 sc-215291B sc-215291A sc-215291C | 5 mg 10 mg 25 mg 50 mg | $66.00 $124.00 $246.00 $456.00 | 13 | |
Mdivi-1 is a mitochondrial division inhibitor that targets the dynamin-related protein 1 (Drp1). By inhibiting mitochondrial fission, Mdivi-1 can potentially influence mitochondrial function, including VDAC2 activity. | ||||||
Rottlerin | 82-08-6 | sc-3550 sc-3550B sc-3550A sc-3550C sc-3550D sc-3550E | 10 mg 25 mg 50 mg 1 g 5 g 20 g | $82.00 $163.00 $296.00 $2050.00 $5110.00 $16330.00 | 51 | |
Rottlerin, a natural polyphenol, has been associated with mitochondrial alterations. It is known to modulate various cellular pathways, including PKC and ROS. Its impact on mitochondrial function suggests a potential role in VDAC2 regulation. | ||||||
Carbonyl Cyanide m-Chlorophenylhydrazone | 555-60-2 | sc-202984A sc-202984 sc-202984B | 100 mg 250 mg 500 mg | $75.00 $150.00 $235.00 | 8 | |
Carbonyl cyanide m-chlorophenyl hydrazone (CCCP) is a mitochondrial uncoupler that dissipates the proton gradient. By disrupting mitochondrial membrane potential, CCCP can potentially influence VDAC2 activity. | ||||||
Auranofin | 34031-32-8 | sc-202476 sc-202476A sc-202476B | 25 mg 100 mg 2 g | $150.00 $210.00 $1899.00 | 39 | |
Auranofin, a gold-containing compound, inhibits thioredoxin reductase and modulates cellular redox balance. Its impact on redox signaling and mitochondrial function suggests a potential role in VDAC2 regulation. | ||||||
Salinomycin | 53003-10-4 | sc-253530 sc-253530C sc-253530A sc-253530B | 5 mg 10 mg 25 mg 100 mg | $159.00 $236.00 $398.00 $465.00 | 1 | |
Salinomycin is an antibiotic known for its selectivity against cancer stem cells. Its impact on mitochondrial function and calcium homeostasis suggests a potential role in VDAC2 modulation. | ||||||
Rotenone | 83-79-4 | sc-203242 sc-203242A | 1 g 5 g | $89.00 $254.00 | 41 | |
Rotenone, a natural product, inhibits mitochondrial complex I, disrupting electron transport. Its impact on mitochondrial function suggests a potential role in VDAC2 modulation. | ||||||
GW501516 | 317318-70-0 | sc-202642 sc-202642A | 1 mg 5 mg | $80.00 $175.00 | 28 | |
GW501516 is a selective agonist of peroxisome proliferator-activated receptor delta (PPARδ). PPARs are implicated in mitochondrial biogenesis and function. GW501516's impact on mitochondrial dynamics suggests a potential role in VDAC2 regulation. | ||||||
AICAR | 2627-69-2 | sc-200659 sc-200659A sc-200659B | 50 mg 250 mg 1 g | $60.00 $270.00 $350.00 | 48 | |
AICAR is an activator of AMP-activated protein kinase (AMPK). By activating AMPK, AICAR influences cellular energy homeostasis and potentially modulates VDAC2 activity. | ||||||