Lonidamine is an indazole compound that has been reported to inhibit angiogenic-related endothelial cell functions. This compound has been found to trigger apoptosis in endothelial cells and cause a decrease in proliferation, migration, invasion, and morphogenesis. The apoptotic effects of Lonidamine have been demonstrated to be due to Bax, Bid, caspase-3, and caspase-9 activation, as well as cytochrome c release. Futher studies show that Lonidamine prevents cellular energy metabolism via HXK (hexokinase) inhibition. This compound also blocks CFTR Cl- channels in vitro.
1. De Martino, C., et al. 1984. Oncology. 41: 15-29. PMID: 6717891 2. Gong, X., et al. 2002. Br. J. Pharmacol. 137: 928-936. PMID: 12411425 3. Del Bufalo, D., et al. 2004. Neoplasia. 6: 513-522. PMID: 15548359 4. Sánchez, Y., et al. 2010. J. Pharmacol. Exp. Ther. 335: 114-123. PMID: 20605902
Soluble in ethanol (5 mM), DMSO (100 mM), CHCl3/MeOH 1/1 (9.80-10.20 mg/ml), water (<1 mg/ml at 25° C), DMSO (64 mg/ml at 25° C), and ethanol (<1 mg/ml at 25° C).
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Is there any reccomendation about solvent and solubility please?
Asked by: Yilin
Thank you for your question. This biochemical is soluble in ethanol (5 mM), DMSO (100 mM), CHCl3/MeOH 1/1 (9.80-10.20 mg/ml), water (<1 mg/ml at 25 degrees C), and ethanol (<1 mg/ml at 25 degrees C).
Answered by: Tech Service
Date published: 2019-01-14
What is the appearance of the compound?
Asked by: two2igm05
Thank you for your question. Lonidamine, sc-203115, is in white to off-white powder form.
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Sanchez et alSanchez et al. (PubMed ID 20605902) found that lonidamine caused mitochondrial transmembrane potential dissipation and apoptosis in human myeloid leukemia cell lines. -SCBT Publication Review
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