Molecular structure of Clofilium tosylate, CAS Number: 92953-10-1
Clofilium tosylate (CAS 92953-10-1)
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Alternate Names:
4-Chloro-N,N-diethyl-N-heptylbenzenebutanaminium . tosylate
Application:
Clofilium tosylate is a K+ channel blocker
CAS Number:
92953-10-1
Molecular Weight:
510.2
Molecular Formula:
C21H37ClN•C7H7O3S
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
Clofilium tosylate is a quaternary ammonium compound that acts as potassium channel blocker. Clofilium is a class III agent. Studies report that in a concentration dependent manner, Clofilium tosylate weakens the contraction induced by Galanin.
Clofilium tosylate (CAS 92953-10-1) References
- Dissipation of potassium and proton gradients inhibits mitochondrial hyperpolarization and cytochrome c release during neural apoptosis. | Poppe, M., et al. 2001. J Neurosci. 21: 4551-63. PMID: 11426445
- Isoprostane-mediated secretion from human airway epithelial cells. | Cowley, EA. 2003. Mol Pharmacol. 64: 298-307. PMID: 12869634
- Prevention of clofilium-induced torsade de pointes by prostaglandin E2 does not involve ATP-dependent K+ channels. | Farkas, A. and Coker, SJ. 2003. Eur J Pharmacol. 472: 189-96. PMID: 12871753
- Block of heart potassium channels by clofilium and its tertiary analogs: relationship between drug structure and type of channel blocked. | Arena, JP. and Kass, RS. 1988. Mol Pharmacol. 34: 60-6. PMID: 2455861
- The differential response of normal and ischaemic Purkinje fibres to clofilium, d-sotalol and bretylium. | Gough, WB. and el-Sherif, N. 1989. Cardiovasc Res. 23: 554-9. PMID: 2590928
- Molecular identification of the dominant-negative, splicing isoform of the two-pore domain K(+) channel K(2P)5.1 in lymphoid cells and enhancement of its expression by splicing inhibition. | Endo, K., et al. 2015. Biochem Pharmacol. 98: 440-52. PMID: 26475531
- Efficient clofilium tosylate-mediated rescue of POLG-related disease phenotypes in zebrafish. | Facchinello, N., et al. 2021. Cell Death Dis. 12: 100. PMID: 33469036
- Modeling human brain rhabdoid tumor by inactivating tumor suppressor genes in induced pluripotent stem cells. | Hua, T., et al. 2024. Bioact Mater. 31: 136-150. PMID: 37637078
- Effects of clofilium, a K channel blocker, on electrogenic K secretion and afferent discharge at the frog semicircular canal. A preliminary report. | Rossi, ML., et al. 1996. Acta Otolaryngol. 116: 277-9. PMID: 8725531
- Contractile effects of porcine galanin(1-29)-NH2 on the rat isolated gastric fundus: mediation by potassium ions. | Korolkiewicz, R., et al. 1997. Pharmacol Res. 36: 147-51. PMID: 9344644
Inhibitor of:
CatSperγ, CLC-K1, CLIC3, GPR89, GPR89B, KCC4, KCNC4, KCNE1L, KCNE4, KCNG1, KCNG2, KCNG3, KCNH3, KCNH5, KCNT1, KCNT2, KCNV2, KIR2.6, Kir3, KIR7.1, KV6.3, LRRC26, LRRC8B, OR10H5, SVOP, TALK-2, THIK-1, TMC6, TMEM17, TMEM175, TMEM247, TMEM38B, TREK-1, TWIK-2, and TWIK-3.Activator of:
KCNH3, KCNT1, SCRN3, SLC26A10, TASK-3, TMEM206, and VDAC2.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Clofilium tosylate, 25 mg | sc-391228 | 25 mg | $428.00 | |||
Clofilium tosylate, 100 mg | sc-391228A | 100 mg | $1020.00 |