The chemical class referred to as VCX-A Inhibitors encompasses a group of compounds intricately designed to selectively target VCX-A, a molecular entity associated with reproductive biology and male fertility. VCX-A, or Variable Charge X-linked protein-A, is a member of the VCX family located on the X chromosome. The specific functions and regulatory mechanisms of VCX-A are subjects of ongoing research within the field of reproductive genetics. While the broader VCX family is recognized for its involvement in spermatogenesis and male reproductive health, the unique characteristics of VCX-A and its precise role in cellular processes are areas of exploration for researchers. Inhibitors within the VCX-A Inhibitors class are meticulously engineered molecules with the primary goal of modulating the activity or function of VCX-A, thereby inducing an inhibitory effect. Researchers in this field utilize a multifaceted approach, integrating insights from molecular genetics, structural biology, and medicinal chemistry to unravel the complex molecular interactions between the inhibitors and the target VCX-A.
Structurally, VCX-A Inhibitors are characterized by specific molecular features designed to facilitate selective binding to VCX-A. This selectivity is crucial to minimize unintended effects on other VCX family members or cellular components, ensuring a focused impact on the intended molecular target. The development of inhibitors within this chemical class involves a comprehensive exploration of structure-activity relationships, optimization of pharmacokinetic properties, and a deep understanding of the molecular mechanisms associated with VCX-A. As researchers delve deeper into the functional aspects of VCX-A Inhibitors, the knowledge generated contributes not only to deciphering the specific roles of Variable Charge X-linked protein-A but also to advancing our broader comprehension of male reproductive biology and the intricate molecular events governing fertility processes. The exploration of VCX-A Inhibitors stands as a significant avenue for expanding fundamental knowledge in reproductive genetics and cellular physiology.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
5-Azacytidine | 320-67-2 | sc-221003 | 500 mg | $280.00 | 4 | |
This compound can cause DNA demethylation, potentially affecting the expression of genes like VCX-A by altering epigenetic marks. | ||||||
5-Aza-2′-Deoxycytidine | 2353-33-5 | sc-202424 sc-202424A sc-202424B | 25 mg 100 mg 250 mg | $214.00 $316.00 $418.00 | 7 | |
Similar to 5-azacytidine, decitabine is a DNA methyltransferase inhibitor that can change gene expression patterns, possibly including VCX-A. | ||||||
Suberoylanilide Hydroxamic Acid | 149647-78-9 | sc-220139 sc-220139A | 100 mg 500 mg | $130.00 $270.00 | 37 | |
Vorinostat is a histone deacetylase inhibitor, which may upregulate or downregulate the expression of various genes, potentially including VCX-A. | ||||||
Trichostatin A | 58880-19-6 | sc-3511 sc-3511A sc-3511B sc-3511C sc-3511D | 1 mg 5 mg 10 mg 25 mg 50 mg | $149.00 $470.00 $620.00 $1199.00 $2090.00 | 33 | |
Trichostatin A, another histone deacetylase inhibitor, could modify chromatin structure and affect VCX-A gene expression. | ||||||
Mithramycin A | 18378-89-7 | sc-200909 | 1 mg | $54.00 | 6 | |
This compound binds to GC-rich DNA sequences, potentially inhibiting transcription factors that regulate genes like VCX-A. | ||||||
Rapamycin | 53123-88-9 | sc-3504 sc-3504A sc-3504B | 1 mg 5 mg 25 mg | $62.00 $155.00 $320.00 | 233 | |
Sirolimus inhibits mTOR, which is involved in the regulation of protein synthesis and could indirectly affect VCX-A expression. | ||||||
Retinoic Acid, all trans | 302-79-4 | sc-200898 sc-200898A sc-200898B sc-200898C | 500 mg 5 g 10 g 100 g | $65.00 $319.00 $575.00 $998.00 | 28 | |
Retinoic acid regulates gene expression through retinoic acid receptors and may alter the transcription of VCX-A. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $121.00 $392.00 | 148 | |
This is a PI3K inhibitor that can affect various signaling pathways, potentially influencing VCX-A gene expression. | ||||||
Actinomycin D | 50-76-0 | sc-200906 sc-200906A sc-200906B sc-200906C sc-200906D | 5 mg 25 mg 100 mg 1 g 10 g | $73.00 $238.00 $717.00 $2522.00 $21420.00 | 53 | |
Actinomycin D intercalates into DNA and inhibits RNA polymerase, which could decrease transcription of genes including VCX-A. | ||||||
Spironolactone | 52-01-7 | sc-204294 | 50 mg | $107.00 | 3 | |
As an aldosterone antagonist, spironolactone can modulate gene transcription, possibly impacting VCX-A expression. | ||||||