VCX-A Antibody (AL-78): sc-135600

VCX-A Antibody (AL-78) is a mouse monoclonal IgG2a kappa light chain antibody that detects the VCX-A protein of human origin by western blotting (WB), immunoprecipitation (IP), and enzyme-linked immunosorbent assay (ELISA). Anti-VCX-A antibody (AL-78) is available as a non-conjugated format, providing researchers with a reliable tool for studying this important protein. VCX-A (AL-78) antibody enables detection of VCX-A protein primarily in male germ cells, where VCX-A plays a crucial role in spermatogenesis, the process of sperm cell development. This localization is significant because proper spermatogenesis is essential for male fertility, and any disruptions in this process can lead to infertility or other reproductive issues. The VCX gene family, which includes VCX-A, is located on the X chromosome and is known for encoding small, highly charged proteins that are specifically expressed in male germ cells. Notably, mutations or deletions in the genes encoding VCX proteins have been linked to X-linked mental retardation, highlighting the importance of VCX-A in both reproductive health and neurological function. Anti-VCX-A antibody (AL-78) serves as an invaluable resource for researchers investigating the roles of VCX-A in spermatogenesis and its implications in genetic disorders.

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VCX-A Antibody (AL-78) References:

1. A human sex-chromosomal gene family expressed in male germ cells and encoding variably charged proteins.  |  Lahn, BT. and Page, DC. 2000. Hum Mol Genet. 9: 311-9. PMID: 10607842
2. A member of a gene family on Xp22.3, VCX-A, is deleted in patients with X-linked nonspecific mental retardation.  |  Fukami, M., et al. 2000. Am J Hum Genet. 67: 563-73. PMID: 10903929
3. Expression and localization of VCX/Y proteins and their possible involvement in regulation of ribosome assembly during spermatogenesis.  |  Zou, SW., et al. 2003. Cell Res. 13: 171-7. PMID: 12862317
4. Identification of an mRNA-decapping regulator implicated in X-linked mental retardation.  |  Jiao, X., et al. 2006. Mol Cell. 24: 713-722. PMID: 17157254
5. A shared promoter region suggests a common ancestor for the human VCX/Y, SPANX, and CSAG gene families and the murine CYPT family.  |  Hansen, MA., et al. 2008. Mol Reprod Dev. 75: 219-29. PMID: 17342728
6. Analysis of the VCX3A, VCX2 and VCX3B genes shows that VCX3A gene deletion is not sufficient to result in mental retardation in X-linked ichthyosis.  |  Cuevas-Covarrubias, SA. and González-Huerta, LM. 2008. Br J Dermatol. 158: 483-6. PMID: 18076704
7. Normal intelligence and social interactions in a male patient despite the deletion of NLGN4X and the VCX genes.  |  Mochel, F., et al. 2008. Eur J Med Genet. 51: 68-73. PMID: 18194880