Date published: 2025-10-25

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V-ATPase G3 Inhibitors

V-ATPase G3 Inhibitors are a specialized class of chemical compounds designed to interact with and inhibit the activity of the V-type ATPase enzyme complex, specifically targeting the G3 subunit. V-type ATPases are essential for acidifying various intracellular compartments and are integral to numerous cellular processes, including protein sorting, neurotransmitter release, and cellular pH regulation. The G3 subunit is a crucial component of this enzyme complex, contributing to its structural stability and functional activity. Inhibitors of this class are crafted to bind with high specificity to the G3 subunit, thereby disrupting its function and altering the overall activity of the V-ATPase complex.Chemically, V-ATPase G3 Inhibitors often feature a diverse range of molecular structures that facilitate selective binding to the G3 subunit. These inhibitors can include small organic molecules, peptides, or other synthetic constructs that are designed through methods such as structure-based drug design, combinatorial chemistry, and high-throughput screening. The design and synthesis of these inhibitors involve targeting specific binding sites on the G3 subunit, which may include interactions with amino acid residues that are critical for the subunit's stability and function. Advanced techniques in molecular modeling and computational chemistry are frequently employed to predict and enhance the binding affinity of these inhibitors. As a result, the V-ATPase G3 Inhibitors represent a sophisticated approach to modulating the activity of the V-ATPase complex by specifically targeting and disrupting the function of the G3 subunit.

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Items 1 to 10 of 12 total

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Product NameCAS #Catalog #QUANTITYPriceCitationsRATING

Trichostatin A

58880-19-6sc-3511
sc-3511A
sc-3511B
sc-3511C
sc-3511D
1 mg
5 mg
10 mg
25 mg
50 mg
$149.00
$470.00
$620.00
$1199.00
$2090.00
33
(3)

This histone deacetylase inhibitor could downregulate V-ATPase G3 expression by removing acetyl groups from histones, leading to a condensed chromatin state and reduced transcriptional activity at the V-ATPase G3 gene locus.

5-Azacytidine

320-67-2sc-221003
500 mg
$280.00
4
(1)

This DNA methyltransferase inhibitor might decrease V-ATPase G3 expression by incorporating into DNA and causing demethylation of gene promoter regions, potentially silencing gene transcription.

Suberoylanilide Hydroxamic Acid

149647-78-9sc-220139
sc-220139A
100 mg
500 mg
$130.00
$270.00
37
(2)

As a histone deacetylase inhibitor, Suberoylanilide Hydroxamic Acid could reduce V-ATPase G3 expression by promoting a closed chromatin confirmation, thereby hindering the access of transcription machinery to the V-ATPase G3 gene.

5-Aza-2′-Deoxycytidine

2353-33-5sc-202424
sc-202424A
sc-202424B
25 mg
100 mg
250 mg
$214.00
$316.00
$418.00
7
(1)

This agent could inhibit V-ATPase G3 expression by the demethylation of CpG islands in the gene's promoter, potentially leading to the repression of its transcription.

Retinoic Acid, all trans

302-79-4sc-200898
sc-200898A
sc-200898B
sc-200898C
500 mg
5 g
10 g
100 g
$65.00
$319.00
$575.00
$998.00
28
(1)

Through its role as an activator of retinoic acid receptors, Retinoic Acid might downregulate V-ATPase G3 by binding to response elements in the gene's promoter, altering the transcription of the gene.

Genistein

446-72-0sc-3515
sc-3515A
sc-3515B
sc-3515C
sc-3515D
sc-3515E
sc-3515F
100 mg
500 mg
1 g
5 g
10 g
25 g
100 g
$26.00
$92.00
$120.00
$310.00
$500.00
$908.00
$1821.00
46
(1)

By inhibiting specific tyrosine kinases, Genistein might reduce the expression of V-ATPase G3 by hindering signal transduction pathways that promote the transcription of this gene.

Curcumin

458-37-7sc-200509
sc-200509A
sc-200509B
sc-200509C
sc-200509D
sc-200509F
sc-200509E
1 g
5 g
25 g
100 g
250 g
1 kg
2.5 kg
$36.00
$68.00
$107.00
$214.00
$234.00
$862.00
$1968.00
47
(1)

This compound could decrease V-ATPase G3 expression by directly interacting with transcription factors or through the inhibition of histone acetyltransferases that are necessary for transcriptional activation.

Resveratrol

501-36-0sc-200808
sc-200808A
sc-200808B
100 mg
500 mg
5 g
$60.00
$185.00
$365.00
64
(2)

Resveratrol might inhibit V-ATPase G3 expression by activating sirtuins that deacetylate histones associated with the gene, leading to transcriptional repression.

Sodium Butyrate

156-54-7sc-202341
sc-202341B
sc-202341A
sc-202341C
250 mg
5 g
25 g
500 g
$30.00
$46.00
$82.00
$218.00
19
(3)

By inhibiting histone deacetylation, Sodium Butyrate could lead to a decrease in V-ATPase G3 expression through the induction of a compact chromatin structure that is less permissive for transcription.

Mithramycin A

18378-89-7sc-200909
1 mg
$54.00
6
(1)

This compound might inhibit expression of V-ATPase G3 by binding to GC-rich sequences in the promoter region of the gene, disrupting the binding of transcription factors necessary for gene activation.